Recombinant Full Length Dog C-X-C Chemokine Receptor Type 3(Cxcr3) Protein, His-Tagged

Cat.No. : RFL31870CF
Product Overview : Recombinant Full Length Dog C-X-C chemokine receptor type 3(CXCR3) Protein (Q5KSK8) (1-365aa), fused to N-terminal His tag, was expressed in E. coli.
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Source : E.coli expression system
Species : Canis lupus familiaris (Dog) (Canis familiaris)
Tag : His
Form : Lyophilized powder
Protein Length : Full Length (1-365)
AA Sequence : MVPEMSERQVFQASELTYLLENCSS SYDYAENESDSCCASPPCPQDISLN FDRAFLPALY GLLFLLGLLGNGAVAAVLCSQRAAR TSTDTFLLHLAVADMLLVLTLPLWR VDTAVQWVFG SGLCKVAGALFNINFYAGALLLACI SFDRYLSIVHATQPYRRGPPARVTL TCVVVWGLCL FFAIPDFIFLSANRDERLNAMHCRY NFPQVGRTALRGLQLVAGFLLPLLV MAYCYARILA VLLVSRGQRRQRRMRLVVVVVVAFA LCWTPYHLVVLVDTLMDLGALDRNC GRESRVDVAK SVTSGLGYMHCCLNPLLYAFVGVKF RERMWMLLLRLGCPDHRGHQRHPTL SRRESSWSET PSTPR
Purity : Greater than 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Storage : Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Storage Buffer : Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Gene Name : CXCR3
Synonyms : CXCR3; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Interferon-inducible protein 10 receptor; IP-10 receptor; CD antigen CD183
UniProt ID : Q5KSK8
Gene Name : CXCR3
Synonyms : CXCR3; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Interferon-inducible protein 10 receptor; IP-10 receptor; CD antigen CD183
UniProt ID : Q5KSK8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
12/11/2019

    The continuous innovation and improvements made by the manufacturer indicated a promising future for the product.

    07/30/2019

      Inclusion of the product consistently led to a significant upregulation of target protein expression levels.

      12/19/2016

        We were excited about the product's role in driving future discoveries in our field of study.

        Q&As (7)

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        What is the primary role of chemokines and their receptors, particularly CXCR3, in immune cell processes? 10/18/2020

        The primary role of chemokines and their receptors, including CXCR3, is in the recruitment, activation, and differentiation of immune cells.

        How many variant isoforms of CXCR3 exist, and what are their names? 03/20/2020

        There are three variant isoforms of CXCR3: CXCR3A, CXCR3B, and CXCR3alt.

        Which ligands are associated with the chemokine receptor CXCR3, and what are their roles during interferon-induced inflammatory responses? 01/18/2019

        The ligands associated with the chemokine receptor CXCR3 are CXCL9, CXCL10, and CXCL11, and they play key roles during interferon-induced inflammatory responses.

        What aspect of the inflammatory process in human skin involving CXCR3 chemokines and isoforms requires further investigation, according to the information provided? 12/18/2018

        The relative contributions of different CXCR3 chemokines and the three variant isoforms to the inflammatory process in human skin require further investigation.

        What is the focus of the review regarding CXCR3, its ligands, and their role in skin during inflammation and carcinogenesis? 05/16/2018

        The review focuses on the biology of CXCR3 and its associated ligands, with particular emphasis on their roles in the skin during inflammation and carcinogenesis.

        In the context of skin cancers, what dual role can the CXCR3 receptor play, and how does its expression on different cell types contribute to cancer outcomes? 01/14/2018

        In skin cancers, the CXCR3 receptor can play a dual role. Its expression on tumor cells can lead to cancer metastasis, while expression on immune cells can promote anti-tumor immune responses.

        What drives the expression of CXCL9, CXCL10, and CXCL11, and what is their function in recruiting CXCR3+ T cells during skin inflammation? 11/27/2016

        The expression of CXCL9, CXCL10, and CXCL11 is driven by inflammation of the skin resulting from infections or autoimmune disease, leading to the recruitment of effector, CXCR3+ T cells from the circulation.

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