CYB5A
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Official Full Name
cytochrome b5 type A (microsomal)
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Overview
The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CYB5A; cytochrome b5 type A (microsomal); CYB5, cytochrome b 5 , cytochrome b5 (microsomal); cytochrome b5; type 1 cyt-b5; CYB5; MCB5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Equus caballus (Horse)
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Oryctolagus cuniculus (Rabbit)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Sus scrofa (Pig)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- MYC
- DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | CYB5A-27555TH | Recombinant Human CYB5A, His-tagged | E.coli | His |
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| Human | CYB5A-2208H | Recombinant Human CYB5A Protein, GST-tagged | Wheat Germ | GST |
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| Human | CYB5A-22H | Recombinant Human CYB5A protein, His-tagged | E.coli | His |
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| Human | CYB5A-11744H | Recombinant Human CYB5A, GST-tagged | E.coli | GST | 1-108a.a. | |
| Human | CYB5A-27557TH | Recombinant Human CYB5A, His-tagged | His |
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| Human | CYB5A-7146HCL | Recombinant Human CYB5A 293 Cell Lysate | HEK293 | N/A |
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| Human | CYB5A-2374HF | Recombinant Full Length Human CYB5A Protein, GST-tagged | In Vitro Cell Free System | GST | 134 amino acids |
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| Human | CYB5A-1662HFL | Recombinant Full Length Human CYB5A Protein, C-Flag-tagged | Mammalian cells | Flag |
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| Human | CYB5A-001H | Recombinant Human CYB5A Protein, His-tagged | Insect Cell | His | ||
| Human | CYB5A-694H-B | Recombinant Human CYB5A Protein Pre-coupled Magnetic Beads | HEK293 |
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| Human | CYB5A-694H | Recombinant Human CYB5A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | Cyb5a-427M | Recombinant Mouse Cyb5a Protein, MYC/DDK-tagged | HEK293T | MYC/DDK |
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| Rat | CYB5A-1700R | Recombinant Rat CYB5A Protein | Mammalian Cell | His |
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| Rat | CYB5A-1359R | Recombinant Rat CYB5A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | CYB5A-1359R-B | Recombinant Rat CYB5A Protein Pre-coupled Magnetic Beads | HEK293 |
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| Bos taurus (Bovine) | RFL24727BF | Recombinant Full Length Bovine Cytochrome B5(Cyb5A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-134) |
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| Equus caballus (Horse) | RFL9499EF | Recombinant Full Length Horse Cytochrome B5(Cyb5A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-134) |
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| Gallus gallus (Chicken) | RFL13957GF | Recombinant Full Length Chicken Cytochrome B5(Cyb5A) Protein, His-Tagged | E.coli expression system | His | Full Length (1-138) |
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| Homo sapiens (Human) | RFL16619HF | Recombinant Full Length Human Cytochrome B5(Cyb5A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-134) |
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| Mus musculus (Mouse) | RFL20890MF | Recombinant Full Length Mouse Cytochrome B5(Cyb5A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-134) |
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| Oryctolagus cuniculus (Rabbit) | RFL23898OF | Recombinant Full Length Rabbit Cytochrome B5(Cyb5A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-134) |
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| Rattus norvegicus (Rat) | RFL27014RF | Recombinant Full Length Rat Cytochrome B5(Cyb5A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-134) |
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| Rhesus Macaque | CYB5A-1122R | Recombinant Rhesus monkey CYB5A Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | CYB5A-947R-B | Recombinant Rhesus Macaque CYB5A Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rhesus Macaque | CYB5A-947R | Recombinant Rhesus Macaque CYB5A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Sus scrofa (Pig) | RFL30016SF | Recombinant Full Length Pig Cytochrome B5(Cyb5A) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (2-134) |
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| Zebrafish | CYB5A-12352Z | Recombinant Zebrafish CYB5A | Mammalian Cell | His |
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| Chicken | CYB5A-1144C | Recombinant Chicken CYB5A | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- CYB5A Related Research Area
CYB5A involved in several pathways and played different roles in them. We selected most pathways CYB5A participated on our site, such as Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYB5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | DLAT;INSIG1;CERS5;TPH2;CYP2Y3;ACY3.1;CIAPIN1;COX15;ETFDH |
| Metabolism of vitamins and cofactors | SLC46A1;NAMPT;SLC5A6B;SLC19A2;CTRC;CYB5A;TCN1;CYB5R3;ELA2L |
| Metabolism of water-soluble vitamins and cofactors | SLC2A3;SLC25A32;CYB5R3;SLC52A3;CTRB1;SLC25A32B;SLC25A16;SLC5A6B;ELA2 |
| Vitamin C (ascorbate) metabolism | SLC23A2;CYB5R3;CYB5A |
| cytochrome P450 | CYB5A;CYB5R3;CYB5B;CYP4F12;CYP4Z1;CYP2W1;CYP20A1;CYP2A7;POR |
CYB5A has several biochemical functions, for example, aldo-keto reductase (NADP) activity, cytochrome-c oxidase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYB5A itself. We selected most functions CYB5A had, and list some proteins which have the same functions with CYB5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aldo-keto reductase (NADP) activity | AKR1C4;SDR42E1;KCNAB2;H2-KE6;AKR1C3;AKR1C21;SDR16C6;HSD3B6;SPR |
| cytochrome-c oxidase activity | COX7B2;COX6B1;SURF1;COX5A;COX7A2;COX6B2;COX8C;COX5B;COA6 |
| enzyme binding | KALRN;CRB2;ITGB3;HIST1H2AK;AXIN2;CTNNB1;RAC1;ATF7;TGFB1 |
| heme binding | CYP2C19;SRC;BACH1;CYP2C54;CYP1A;CYP2X9;CYP4A11;CYP17A1;SDHDB |
| metal ion binding | ZNF395B;TGM1;CAR5A;Car9;ZFP628;ZNF213;PRKCH;UNC13A;FGD3 |
CYB5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYB5A here. Most of them are supplied by our site. Hope this information will be useful for your research of CYB5A.
CYP3A5; TRAF6; UGT1A4; CYP2W1; q9wmx2-pro_0000037550
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, mutations in the CYB5A gene can lead to disorders such as methemoglobinemia, a condition characterized by the presence of elevated levels of methemoglobin in the blood.
Modulating CYB5A activity could have implications for drug efficacy, toxicity, and individualized drug dosing in clinical practice.
Studies have shown that the expression of CYB5A can vary among different populations, which could impact drug metabolism and response to medications.
Yes, given its importance in drug metabolism, the CYB5A protein could be a potential target for therapeutic interventions aimed at optimizing drug response and minimizing adverse effects.
Yes, certain drugs may interact with the CYB5A protein, affecting its activity and potentially leading to drug-drug interactions and altered metabolism.
Customer Reviews (3)
Write a reviewIts high quality greatly enhances the reliability and reproducibility of experimental data.
Whether I need expertise in experimental optimization or troubleshooting, I can rely on the manufacturer's support to promptly address any concerns or queries.
CYB5A protein is known for its versatility and functionality, enabling researchers to explore various biological processes and molecular interactions.
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