DDIT3 Protein


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Official Full Name DNA-damage-inducible transcript 3
Background GADD 153 has been described as a growth arrest and DNA damage-inducible gene that encodes a C/EBP-related nuclear protein. GADD153 expression is induced by a variety of cellular stresses, inducing nutrient deprivation and merabolic perturbations. GADD153 functions to block cells in G1 to S phase in cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD153 dimers away from “classical” C/EBP binding sites, recognizing instead unique “nonclassical” sites.
Synonyms DDIT3; DNA-damage-inducible transcript 3; DNA damage-inducible transcript 3 protein; C/EBP zeta; CHOP; CHOP10; GADD153; DDIT-3; c/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; growth arrest and DNA damage-inducible protein GADD153; CEBPZ; CHOP-10; MGC4154
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DDIT3-3639H Recombinant Human DDIT3 protein, GST-tagged E.coli GST
    Human DDIT3-3923H Recombinant Human DDIT3 protein, His-tagged E.coli His
    Human DDIT3-126H Recombinant Human DDIT3 protein, T7/His-tagged E.coli T7/His
    Human DDIT3-130H Recombinant Human DNA-damage-inducible Transcript 3 E.coli His
    Human DDIT3-1361H Recombinant Human DNA-damage-inducible Transcript 3, GST-tagged E.coli GST
    Human DDIT3-217H Recombinant Human DDIT3 Protein, GST/His-tagged E.coli GST/His
    Human DDIT3-2442H Recombinant Human DDIT3 Protein, GST-tagged Wheat Germ GST
    Human DDIT3-26512TH Recombinant Human DDIT3, His-tagged E.coli His
    Human DDIT3-4948H Recombinant Human DNA-Damage-Inducible Transcript 3, His-tagged Human His
    Human DDIT3-7027HCL Recombinant Human DDIT3 293 Cell Lysate HEK293 N/A
    Human DDIT3-859H Recombinant Human DDIT3 Protein, GST-His-tagged E.coli GST/His
    Mouse Ddit3-1655M Recombinant Mouse Ddit3 protein, His & GST-tagged E.coli His/GST
    Mouse DDIT3-4387M Recombinant Mouse DDIT3 Protein Mammalian Cell His
    Rhesus Macaque DDIT3-1206R Recombinant Rhesus monkey DDIT3 Protein, His-tagged Mammalian Cell His
    Zebrafish DDIT3-5226Z Recombinant Zebrafish DDIT3 Mammalian Cell His

    DDIT3 involved in several pathways and played different roles in them. We selected most pathways DDIT3 participated on our site, such as ATF-2 transcription factor network, ATF4 activates genes, ATF6-alpha activates chaperone genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDIT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ATF-2 transcription factor network JDP2; JUN; HRK; KAT5; JUNB; DUSP10; DUSP1; POU2F1; RUVBL2; KCNA3
    ATF4 activates genes KCNA3; EXOSC8; DDIT3; DCP2
    ATF6-alpha activates chaperone genes DDIT3; KCNA3
    ATF6-alpha activates chaperones KCNA3; YY2; DDIT3
    Adipogenesis CTNNB1; MIXL1; NR2F1A; AHR; STIL; NR2F1; NR1H3; GATA2; BMP1; CREB1
    MAPK signaling pathway MAP3K7; CACNA1BA; TAB2; PRKCA; MKNK2B; PPM1BB; NTF4; ARRB2A; ARRB2B; HSPB1
    Metabolism of proteins TPP1; IGFBP5; MPDU1A; TRAPPC2; MBOAT4; TOMM20; NANP; CKAP4; NSMCE2; ADAMTS3
    Non-alcoholic fatty liver disease (NAFLD) INS1; PPARA; INSR; FASLG; DDIT3; IL1A; PRKAA1; NDUFB7; PKLR; NDUFC2-KCTD14

    DDIT3 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, cAMP response element binding protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDIT3 itself. We selected most functions DDIT3 had, and list some proteins which have the same functions with DDIT3. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding BHLHE41; E2F5; HOXC4A; PRM2; ZFP292; ZZZ3; IRX1A; ZFP513; SP140; LASS2
    RNA polymerase II core promoter proximal region sequence-specific DNA binding POU2F2; TFAP2A; DLX5; RAX; JDP2; NKX2-8; BCL11A; GLI2; TGIF1; ZNF460
    cAMP response element binding protein binding CRTC2; CRTC1; CRTC3; CREB3; DDIT3; KCNA3; CRTC1A; DAPK3; CREM; ATF2
    leucine zipper domain binding DAPK3; AATF; PAWR; MKL1; CRX; ATF4; NRL; DDIT3; KCNA3; ERC1
    protein binding SMURF1; SERPINB3C; ADAMTS4; DPM1; TINF2; GIT1; Car8; RGMA; CXCL11; CACNG2
    protein heterodimerization activity SNX2; H2AFV; UGT1A2; IRAK3; SDCBP2; DMBX1; ODZ4; PIK3R1; HIST1H4H; UGT1A3
    NOT protein homodimerization activity MSH6; EXT2; MLXIPL; NUDT16L1; MYO9B; KCNA3; DDIT3; MSH3; MECOM
    transcription corepressor activity SOD3; JUB; BCOR; PIAS1; ZHX3; YAF2; TBL1XR1B; NR0B1; HOXC6; WNT4
    transcription factor activity, sequence-specific DNA binding DMRT3; ATF3; FOXG1A; HOXC6B; CBFA2T3; ZNF613; ZFP629; ETV5B; MSC; RXRA
    transcription factor binding STK4; ARNT; DNMT1; TRIM11; RB1; IFI16; SP1; GCM1; ZFPM2; LCOR
    transcription regulatory region DNA binding BCL11AA; ZFP335; KDM1A; GATA6; SNCA; DDIT3; IKZF2; ZNF335; ETV5; SALL3B
    transcription regulatory region sequence-specific DNA binding HIF1AL; KCNA3; NFE2; GATA1; EPAS1B; NFE2L1; BAHD1; MKL1; POU5F1; NR5A1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ARNT2; GMEB1; KCNA3; MYBL1; HNRNPK; IRF1; RBPJ; BSX; NR5A2; NFIC

    DDIT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDIT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDIT3.


    Richards, M; Phoon, CW; et al. A New Class of Pluripotent Stem Cell Cytotoxic Small Molecules. PLOS ONE 9:-(2014).
    Carvalheira, GM; Nozima, BHN; et al. DDIT3, STT3A (ITM1), ARG2 and FAM129A (Niban, C1orf24) in diagnosing thyroid carcinoma: variables that may affect the performance of this antibody-based test and promise. MODERN PATHOLOGY 26:611-613(2013).

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