DES
-
Official Full Name
desmin -
Overview
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008] -
Synonyms
DES;desmin;CSM1;CSM2;LGMD2R;mutant desmin p.K241E;intermediate filament protein
Recombinant Proteins
- Human
- Bacillus subtilis
- Rhesus macaque
- Rat
- Mouse
- Chicken
- E.coli
- E.Coli/Yeast
- Mammalian Cells
- Wheat Germ
- Insect Cells
- HEK293
- Chicken Gizzard
- In Vitro Cell Free System
- GST
- His
- Non
- MBP
- Flag
- Avi
- Fc
- EGFP
Involved Pathway
DES involved in several pathways and played different roles in them. We selected most pathways DES participated on our site, such as Arrhythmogenic right ventricular cardiomyopathy,Arrhythmogenic right ventricular cardiomyopathy (ARVC),Aurora B signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA10,LMNA,ITGB1,ITGA8,ACTG1,CACNG8,ITGB8,SGCA,LAMA2,SLC8A1 |
| Striated Muscle Contraction | TNNI2A.1,MYBPC1,TMEM8C,TNNT3A,TMOD2,TNNT1,TNNI2A.3,VIML,TNNT3B,ACTA1B |
| Dilated cardiomyopathy | CACNG2,ITGB6,DAG1,PLN,CACNG6,ITGA5,CACNG1,TPM4,ACTC1,TGFB3 |
| Muscle contraction | DMD,TMOD4,LMOD1,VIML,MYBPC2,MYL9,SORBS3,TNNI2B.1,ANXA6,SMYHC3 |
| Aurora B signaling | AURKC,NPM1,KIF20A,TACC1,EVI5,NCAPH,CDCA8,NCAPD2,CENPA,AURKB |
| Hypertrophic cardiomyopathy (HCM) | ACTG1,ITGA4,CACNG4,ACTC1,MYL2,CACNA2D2,ITGB8,CACNB2,PRKAG1,ITGB3 |
| Arrhythmogenic right ventricular cardiomyopathy | CDH2,DAG1,DSG2,CTNNA2,JUP,DSC2,CACNG2,DSP,CTNNA1,CACNG3 |
Protein Function
DES has several biochemical functions, for example, cytoskeletal protein binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DES itself. We selected most functions DES had, and list some proteins which have the same functions with DES. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MED12,DHPS,CHCHD6,RSL24D1,GPANK1,RGS20,SPPL2B,ASCL3,UFL1,TCERG1 |
| identical protein binding | VPS41,TLE1,SHMT2,MPST,RASSF3,PPP1R13L,RALYL,EPHA4,RBM10,PHC2 |
| structural constituent of cytoskeleton | TUBA4A,MAPT,TUBG1,NDC80,TUBA8L3,TUBA1C,ACTL6B,BKJ,SPTAN1,TUBA7L |
| cytoskeletal protein binding | ALDOC,EPB41L3B,CDK5,TOR1A,ANXA2,ABI1,EPB41L5,NEBL,MSNB,EPB41L4A |
Interacting Protein
DES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DES here. Most of them are supplied by our site. Hope this information will be useful for your research of DES.
MTM1;MLH1
Resources
Research Area
Cardiac Stem Cell MarkersMyogenesis Markers
Mesenchymal Cells and EMT
Intermediate Filaments
Related Services
Related Products
References
- Gonzales, I; Miranda, JJ; et al. Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study. TROPICAL MEDICINE & INTERNATIONAL HEALTH 20:546-552(2015).
- Liu, YC; Wang, Q; et al. Simultaneous Determination of Malachite Green, Diethylstilbestrol, Medroxyprogesterone, and 3-Amino-2-Oxazolidone in Synbranchoid Eels by a Protein Microarray Method. FOOD ANALYTICAL METHODS 8:1058-1066(2015).
