DES involved in several pathways and played different roles in them. We selected most pathways DES participated on our site, such as Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Aurora B signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Arrhythmogenic right ventricular cardiomyopathy |
CACNG2; CACNG3; CTNNA1; DSG2; CTNNA2; DSC2; JUP; DSP; DAG1; DMD |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
CACNG7; ITGB8; CTNNA2; DSC2; ITGB3; PKP2; Itga10&Itgb1; DAG1; ITGA7; ITGB5 |
| Aurora B signaling |
SMC4; AURKC; NCAPH; INCENP; NSUN2; KIF2C; NDC80; RACGAP1; SGOL1; CBX5 |
| Dilated cardiomyopathy |
TPM3; RYR2; ITGA1; TGFB3; ITGA8; PRKACA; CACNG6; MYL3; CACNB4; TTN |
| Hypertrophic cardiomyopathy (HCM) |
PRKAB1; SGCA; ACTB; TNF; PRKAG2; TNNI3; MYBPC3; EMD; Itga10&Itgb1; ACE |
| Muscle contraction |
TNNI2B.2; MYL6B; TNNI2A.3; MYLZ3; MYL9; TNNT1; SORBS3; DES; LMOD1; TMOD3 |
| Striated Muscle Contraction |
TMOD1; TMOD4; TMOD3; TNNT3B; TNNI2; TNNI2B.1; TNNT3A; VIML; MYBPC2A; TMEM8C |
DES has several biochemical functions, for example, cytoskeletal protein binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DES itself. We selected most functions DES had, and list some proteins which have the same functions with DES. You can find most of the proteins on our site.
| Function |
Related Protein |
| cytoskeletal protein binding |
ALDOC; PTPN3; EPB41L3A; PKD2L1; DES; TOR1AIP1; MYPN; ANXA2A; FARP2; RPH3AL |
| identical protein binding |
SLC22A1; PDCD6; PPPDE2; PRDX1; FXR2; GOT2A; BRAF; TLE1; SDCBP; RB1 |
| protein binding |
SNRPE; UBQLN2; MPHOSPH8; PPP1R12C; SMAD3A; HSP90AB1; SORBS2; FANCL; PTGDR; NOL3 |
| structural constituent of cytoskeleton |
TUBA3E; TLN1; GFAP; TUBGCP4; TUBA2; TUBA8L3; TUBGCP5; ATXN1; KRT6B; TUBA1A |
DES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DES here. Most of them are supplied by our site. Hope this information will be useful for your research of DES.
MTM1; MLH1
Liu, YC; Wang, Q; et al. Simultaneous Determination of Malachite Green, Diethylstilbestrol, Medroxyprogesterone, and 3-Amino-2-Oxazolidone in Synbranchoid Eels by a Protein Microarray Method. FOOD ANALYTICAL METHODS 8:1058-1066(2015).
Gonzales, I; Miranda, JJ; et al. Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study. TROPICAL MEDICINE & INTERNATIONAL HEALTH 20:546-552(2015).
