DES Protein


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Official Full Name desmin
Background This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]
Synonyms DES; desmin; CSM1; CSM2; LGMD2R; mutant desmin p.K241E; intermediate filament protein;
    • Species :
    • Bacillus subtilis
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • Chicken Gizzard
    • E. coli or Yeast
    • E.coli
    • HEK293
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • DDK
    • GST
    • His
    • MBP
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DES-113H Recombinant Human Desmin E.coli N/A
    Human DES-11943H Recombinant Human DES, GST-tagged E.coli GST
    Human DES-168H Recombinant human DES E.coli N/A
    Human DES-196H Recombinant Human DES Mammalian Cell His
    Human DES-2549H Recombinant Human DES Protein, GST-tagged Wheat Germ GST
    Human DES-289H Recombinant Human DES protein, His/MBP-tagged E.coli His/MBP
    Human DES-328H Recombinant Human DES Protein, DDK-tagged Insect Cell DDK
    Human DES-329H Recombinant Human DES Protein, His-tagged E.coli His
    Human DES-330H Recombinant Human DES Protein, His-tagged E.coli His
    Human DES-534H Recombinant Human DES Protein, His-tagged E.coli His
    Mouse DES-4526M Recombinant Mouse DES Protein Mammalian Cell His
    Rat DES-1847R Recombinant Rat DES Protein Mammalian Cell His
    Rhesus Macaque DES-1246R Recombinant Rhesus monkey DES Protein, His-tagged Mammalian Cell His
    Bacillus subtilis DES-0978B Recombinant Bacillus subtilis DES protein, His-tagged E. coli or Yeast His
    Human DES-6969HCL Recombinant Human DES 293 Cell Lysate HEK293 N/A
    Human DES-2476HF Recombinant Full Length Human DES Protein, GST-tagged In Vitro Cell Free System GST
    Human DES-3303H Recombinant Human DES protein, His-tagged E.coli His
    Chicken DES-167C Native chicken DES Chicken Gizzard N/A

    DES involved in several pathways and played different roles in them. We selected most pathways DES participated on our site, such as Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Aurora B signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arrhythmogenic right ventricular cardiomyopathy CTNNA2; DSC2; JUP; DSG2; CACNG3; CACNG2; CTNNA1; DES; DMD; DSP
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGB3; SGCA; CTNNA2; ACTN3; CACNG1; CDH2; SLC8A1; ITGB8; LEF1; CACNG8
    Aurora B signaling NPM1; CBX5; EVI5; NSUN2; KIF20A; TACC1; AURKC; CENPA; NCAPD2; INCENP
    Dilated cardiomyopathy TGFB1; TNNI3; ITGA5; LMNA; TNF; ITGA1; CACNG2; EMD; PRKACB; TGFB2
    Hypertrophic cardiomyopathy (HCM) DMD; CACNB2; ITGA2; MYL3; ITGA7; PRKAG2; ITGB3; TGFB1; MYBPC3; ITGA8
    Muscle contraction MYLZ3; ANXA2; DMD; MYL1; TNNI2B.1; TMOD3; TCAP; DESMA; TNNI1; TRIM72
    Striated Muscle Contraction TMOD2; TMOD1; MYBPC2A; TNNI2; ACTA1; MYLZ3; TNNI2A.3; MYBPC2; TNNI2A.1; SMYHC3

    DES has several biochemical functions, for example, cytoskeletal protein binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DES itself. We selected most functions DES had, and list some proteins which have the same functions with DES. You can find most of the proteins on our site.

    Function Related Protein
    cytoskeletal protein binding LIN7C; PACSIN3; TNNT2A; MSNA; TOR1A; FRMD5; CDK5; LDB3; NCKIPSD; TOR1AIP1
    identical protein binding DYNLRB1; STIM1; BRAF; USP4; TFRC; STAC3; MCM6; SNX8; C1QTNF9; ALK
    protein binding CD247; RIPK1L; Il4ra; CTSC; ARF1; GRIN2C; WWP2; Ntng2; SOCS6; RAB5C
    structural constituent of cytoskeleton TUBA8L4; TUBGCP3; TUBGCP5; VIM; MAPT; NDC80; TUBA8L; NGS; TUBB2B; EPB41

    DES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DES here. Most of them are supplied by our site. Hope this information will be useful for your research of DES.

    MTM1; MLH1

    Liu, YC; Wang, Q; et al. Simultaneous Determination of Malachite Green, Diethylstilbestrol, Medroxyprogesterone, and 3-Amino-2-Oxazolidone in Synbranchoid Eels by a Protein Microarray Method. FOOD ANALYTICAL METHODS 8:1058-1066(2015).
    Gonzales, I; Miranda, JJ; et al. Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study. TROPICAL MEDICINE & INTERNATIONAL HEALTH 20:546-552(2015).

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