DES

  • Official Full Name

    desmin

  • Overview

    This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]
  • Synonyms

    DES; desmin; CSM1; CSM2; LGMD2R; mutant desmin p.K241E; intermediate filament protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bacillus subtilis
  • Bacillus subtilis (strain 168)
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Chicken Gizzard
  • E. coli or Yeast
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • C
  • EGFP
  • His
  • DDK
  • GST
  • His (Fc)
  • Avi
  • His|MBP
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DES-289H Recombinant Human DES protein, His/MBP-tagged E.coli His/MBP 242-270 aa
Human DES-168H Recombinant human DES E.coli N/A
Human DES-329H Recombinant Human DES Protein, His-tagged E.coli His Val260-Leu470
Human DES-328H Recombinant Human DES Protein, DDK-tagged Insect Cell DDK
Human DES-113H Recombinant Human Desmin E.coli N/A
Human DES-196H Recombinant Human DES Mammalian Cell His
Human DES-534H Recombinant Human DES Protein, His-tagged E.coli His Asp117~Gln348
Human DES-330H Recombinant Human DES Protein, His-tagged E.coli His
Human DES-2549H Recombinant Human DES Protein, GST-tagged Wheat Germ GST
Human DES-11943H Recombinant Human DES, GST-tagged E.coli GST 121-470a.a.
Human DES-6969HCL Recombinant Human DES 293 Cell Lysate HEK293 N/A
Human Des-3262H Recombinant Human Des protein, His-tagged HEK293 His Asp117~Gln348
Human DES-2476HF Recombinant Full Length Human DES Protein, GST-tagged In Vitro Cell Free System GST 470 amino acids
Human DES-324H Recombinant Human DES protein, His-tagged E.coli N-His 2-470aa
Human DES-2675H Recombinant Human DES protein(51-460 aa), C-His-tagged E.coli C-His 51-460 aa
Human DES-2676H Recombinant Human DES protein(91-460 aa), C-His-tagged E.coli C-His 91-460 aa
Human DES-1950H Recombinant Human DES Protein (Val260-Leu470), N-His tagged E.coli N-His Val260-Leu470
Human DES-2792H-B Recombinant Human DES Protein Pre-coupled Magnetic Beads HEK293
Human DES-1951H Recombinant Human DES Protein (Met1-Leu470), N-His tagged E.coli N-His Met1-Leu470
Human DES-323H Recombinant Human DES protein, EGFP-tagged E.coli C-EGFP 2-470aa
Human DES-3303H Recombinant Human DES protein, His-tagged E.coli His 121-470 aa
Human DES-2792H Recombinant Human DES Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DES-4526M Recombinant Mouse DES Protein Mammalian Cell His
Mouse DES-2337M Recombinant Mouse DES Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DES-2337M-B Recombinant Mouse DES Protein Pre-coupled Magnetic Beads HEK293
Rat DES-1847R Recombinant Rat DES Protein Mammalian Cell His
Rat DES-1505R-B Recombinant Rat DES Protein Pre-coupled Magnetic Beads HEK293
Rat DES-1505R Recombinant Rat DES Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bacillus subtilis DES-0978B Recombinant Bacillus subtilis DES protein, His-tagged E. coli or Yeast His
Bacillus subtilis (strain 168) RFL17622BF Recombinant Full Length Bacillus Subtilis Fatty Acid Desaturase(Des) Protein, His-Tagged E.coli expression system His Full Length (1-352)
Rhesus Macaque DES-1246R Recombinant Rhesus monkey DES Protein, His-tagged Mammalian Cell His
Rhesus Macaque DES-1071R-B Recombinant Rhesus Macaque DES Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DES-1071R Recombinant Rhesus Macaque DES Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken DES-167C Native chicken DES Chicken Gizzard N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

DES involved in several pathways and played different roles in them. We selected most pathways DES participated on our site, such as Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Aurora B signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arrhythmogenic right ventricular cardiomyopathyJUP;DMD;DSG2;DES;CACNG2;CTNNA2;CDH2;CACNG3;DAG1
Arrhythmogenic right ventricular cardiomyopathy (ARVC)ITGA10;ITGB8;CACNB4;LEF1;CACNB3;CACNB1;LAMA2;CACNA2D4;ACTB
Aurora B signalingAURKB;TACC1;EVI5;NDC80;NPM1;INCENP;CBX5;CENPA;RACGAP1
Dilated cardiomyopathyCACNB3;TGFB3;MYH7;CACNB4;MYL2;PRKACA;PRKACG;CACNA2D4;ITGB3
Hypertrophic cardiomyopathy (HCM)TGFB2;ITGB5;ITGA4;CACNG1;ACTC1;ITGA1;ITGAV;TPM2;CACNB2
Muscle contractionMYL12B;TNNI2B.2;SMYHC3;TNNI2A.3;ANXA6;MYL12A;TNNI2A.1;TNNI2A.4;DES
Striated Muscle ContractionMYLZ3;MYBPC2;TMEM8C;TNNI2A.3;CMLC1;MYBPC3;ACTA1B;TNNT1;ACTA1

DES has several biochemical functions, for example, cytoskeletal protein binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DES itself. We selected most functions DES had, and list some proteins which have the same functions with DES. You can find most of the proteins on our site.

Function Related Protein
cytoskeletal protein bindingPTPN4A;CORO1A;ALDOB;MYLIP;TPM1;FRMD3;EPB41L3B;NF2B;CDK5
identical protein bindingMICALL1;VPS4B;C1QTNF9;RABAC1;FAM108A1;HSD17B10;SMN1;SH3GLB1;SEPT7
protein bindingUSP9X;GATC;CENPW;CBR4;ADAMTS3;PRDM7;ZNF133;PAAF1;HDAC9
structural constituent of cytoskeletonANK1;TPM1;SORBS2;TUBGCP2;YEATS4;GFAP;TUBA8L;TUBA8L3;TLN2A

DES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DES here. Most of them are supplied by our site. Hope this information will be useful for your research of DES.

MTM1; MLH1

Research Area

Related articles

Liu, YC; Wang, Q; et al. Simultaneous Determination of Malachite Green, Diethylstilbestrol, Medroxyprogesterone, and 3-Amino-2-Oxazolidone in Synbranchoid Eels by a Protein Microarray Method. FOOD ANALYTICAL METHODS 8:1058-1066(2015).
Gonzales, I; Miranda, JJ; et al. Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study. TROPICAL MEDICINE & INTERNATIONAL HEALTH 20:546-552(2015).
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