| Species : |
Mouse |
| Source : |
C2C12 |
| Tag : |
Non |
| Description : |
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane and are essential for maintaining the strength and integrity of skeletal, cardiac and smooth muscle fibers. Mutations in this gene affect assembly of intermediate filaments. Mice lacking this gene are able to develop and reproduce but exhibit abnormal muscle fibers. Mutations in the human gene are associated with myofibrillar myopathy, dilated cardiomyopathy, neurogenic scapuloperoneal syndrome and autosomal recessive limb-girdle muscular dystrophy, type 2R. |
| Form : |
Cell-Tissue Lysis buffer |
| Molecular Mass : |
54 kDa |
| Notes : |
Instruction of use: This knockdown cell lysate should be paired with wild-type C2C12 cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins. |
| Storage : |
Store at -20 centigrade for two years. |
| Concentration : |
Lot-specific |
| Shipping : |
Blue Ice |
| Components : |
1 vial of 100 μg WT C2C12 cell lysate
1 vial of 100 μg DES KD C2C12 cell lysate |
| Protein Families : |
Druggable Genome |
| Protein Pathways : |
Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM) |
| Lysate QC : |
RT-qPCR; Western Blotting (WB) |
