Recombinant Human DES, GST-tagged DES-11943H

Recombinant Human DES, GST-tagged

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Recombinant Human DES, GST-tagged

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Cat.No. : DES-11943H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human DES protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description : This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
Source : E.coli
Species : Human
Tag : GST
Protein length : 121-470a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : DES desmin [ Homo sapiens ]
Official Symbol : DES
Synonyms : DES; desmin; CMD1I; CSM1; CSM2; intermediate filament protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793;
Gene ID : 1674
mRNA Refseq : NM_001927
Protein Refseq : NP_001918
MIM : 125660
UniProt ID : P17661
Chromosome Location : 2q35
Pathway : Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Aurora B signaling, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem; Hypertrophic cardiomyopathy (HCM), conserved biosystem;
Function : nebulin binding; protein binding; structural constituent of cytoskeleton;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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