Recombinant Human Desmin DES-113H

Recombinant Human Desmin


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Recombinant Human Desmin

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Cat.No. : DES-113H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human Desmin has a molecular mass of 53,539 dalton and is produced inE.Coli.
Description : This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
Source : Escherichia Coli.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation : The protein was lyophilized from a 1mg/ml solution containing 30 mM Tris/HCI pH 8, 9.5 M urea, 2 mM DTT, 2 mM EDTA and 10 mM methylammonium chloride.
Purity : Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Solubility : It is recommended to reconstitute the lyophilized rHuDesmin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability : Lyophilized rHuDesmin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuDesmin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : DES desmin [ Homo sapiens ]
Synonyms : DES; desmin; CSM1; CSM2; CMD1I; FLJ12025; FLJ39719; FLJ41013; FLJ41793; intermediate filament protein; OTTHUMP0000 0064865
Gene ID : 1674
mRNA Refseq : NM_001927
Protein Refseq : NP_001918
UniProt ID : P17661
Chromosome Location : 2q35
MIM : 125660
Pathway : Arrhythmogenic right ventricular cardiomyopathy (ARVC); Hypertrophic cardiomyopathy (HCM); Muscle contraction
Function : protein binding; structural constituent of cytoskeleton
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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