Recombinant Human Desmin

• Cat.No.: DES-113H
• Product Overview: Recombinant Human Desmin has a molecular mass of 53,539 dalton and is produced inE.Coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
• Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Formulation: The protein was lyophilized from a 1mg/ml solution containing 30 mM Tris/HCI pH 8, 9.5 M urea, 2 mM DTT, 2 mM EDTA and 10 mM methylammonium chloride.
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Solubility: It is recommended to reconstitute the lyophilized rHuDesmin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
• Stability: Lyophilized rHuDesmin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuDesmin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: DES desmin [ Homo sapiens ]
• Synonyms: DES; desmin; CSM1; CSM2; CMD1I; FLJ12025; FLJ39719; FLJ41013; FLJ41793; intermediate filament protein; OTTHUMP0000 0064865
• Gene ID: 1674
• mRNA Refseq: NM_001927
• Protein Refseq: NP_001918
• UniProt ID: P17661
• Chromosome Location: 2q35
• MIM: 125660
• Pathway: Arrhythmogenic right ventricular cardiomyopathy (ARVC); Hypertrophic cardiomyopathy (HCM); Muscle contraction
• Function: protein binding; structural constituent of cytoskeleton