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ENO1

  • Official Full Name

    enolase 1, (alpha)

  • Overview

    This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy.
  • Synonyms

    ENO1; enolase 1, (alpha); ENO1L1, MPB1; alpha-enolase; c-myc promoter-binding protein-1; MBP 1; PPH; enolase-alpha; tau-crystallin; non-neural enolase; alpha enolase like 1; phosphopyruvate hydratase; plasminogen-binding protein; MYC promot;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • GMP Proteins
  • Assay Kits
  • Cattle
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Baculovirus-Insect cells
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • MAT
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • His|Myc
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ENO1-1814H Recombinant Human Enolase 1, (Alpha) E.coli N/A
Human ENO1-2513H Recombinant Human ENO1 protein, His-tagged HEK293 His 1-434aa
Human ENO1-28565TH Recombinant Human ENO1 E.coli N/A
Human ENO1-3309H Recombinant Human ENO1 Protein, GST-tagged Wheat Germ GST
Human ENO1-28561TH Recombinant Human ENO1 N/A
Human ENO1-2512H Recombinant Human ENO1 protein, His-tagged E.coli His Met1-Lys434
Human ENO1-12451H Recombinant Human ENO1, His-tagged E.coli His 1-433a.a.
Human ENO1-6599HCL Recombinant Human ENO1 293 Cell Lysate HEK293 N/A
Human ENO1-0499H Recombinant Human ENO1 Protein (M1-K434), His/Strep tagged E.coli His/Strep M1-K434
Human ENO1-002H Recombinant Human ENO1 Protein E.coli 1-434
Human ENO1-2760H Recombinant Human ENO1 Protein (2-434 aa), His-Myc-tagged Insect Cell His/Myc 2-434 aa
Human ENO1-3995H Recombinant Human ENO1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ENO1-022H Recombinant Human ENO1 Protein E. coli 1-434
Human ENO1-004H Recombinant Human ENO1 Protein E.coli 1-434
Human ENO1-2846H Recombinant Human ENO1 protein, GST-tagged E.coli GST 2-428aa
Human ENO1-842H Recombinant Human ENO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ENO1-4302HF Recombinant Full Length Human ENO1 Protein, GST-tagged In Vitro Cell Free System GST 434 amino acids
Human ENO1-055H Recombinant Human ENO1 Protein E. coli 1-434
Human ENO1-30HFL Recombinant Full Length Human ENO1 Protein, C-Flag-tagged Mammalian cells Flag
Human ENO1-842H-B Recombinant Human ENO1 Protein Pre-coupled Magnetic Beads HEK293
Human ENO1-0498H Recombinant Human ENO1 Protein (M1-K434), Tag Free E.coli No tag M1-K434
Human ENO1-3739H Recombinant Human ENO1 protein, GST-tagged E.coli GST 2-434 aa
Human ENO1-4078H Recombinant Human ENO1 Protein (Met1-Lys434), C-MAT tagged Insect Cells C-MAT Met1-Lys434
Human ENO1-2903H Recombinant Human ENO1 Protein (Pro267-Leu354), N-His tagged E.coli N-His Pro267-Leu354
Human ENO1-0365H Recombinant Human ENO1 Protein (Met1-Lys434), C-MAT-tagged Baculovirus-Insect cells C-MAT Met1-Lys434
Human ENO1-74H Recombinant Human ENO1 Protein (Ser2-Lys434), N-His tagged, Animal-free, Carrier-free E.coli N-His Ser2-Lys434
Mouse Eno1-244M Active Recombinant Mouse Eno1 Protein, His-tagged, Bioactivity Validated E.coli His 1-434aa
Mouse ENO1-5203M Recombinant Mouse ENO1 Protein Mammalian Cell His
Mouse Eno1-103M Recombinant Mouse Eno1 protein, His-tagged E.coli His Met1~Lys434
Mouse Eno1-2847M Recombinant Mouse Eno1 protein, His-tagged E.coli His 2-433aa
Mouse Eno1-01M GMP Recombinant Mouse Eno1 Protein, His-Tagged E.coli His
Mouse Eno1-22M Recombinant Mouse Eno1 Protein (Ser2-Lys434), N-His tagged, Animal-free, Carrier-free E.coli N-His Ser2-Lys434
Mouse ENO1-2791M Recombinant Mouse ENO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Eno1-2827M Recombinant Mouse Eno1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ENO1-2791M-B Recombinant Mouse ENO1 Protein Pre-coupled Magnetic Beads HEK293
Rat ENO1-2098R Recombinant Rat ENO1 Protein Mammalian Cell His
Rat Eno1-207R Recombinant Rat Eno1 protein, His-tagged E.coli His Met1-Lys434
Rat ENO1-1755R Recombinant Rat ENO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ENO1-1755R-B Recombinant Rat ENO1 Protein Pre-coupled Magnetic Beads HEK293
Cattle ENO1-6975C Recombinant Cattle ENO1 protein, His-tagged E.coli His Met1~Lys434 (Accession # Q9XSJ4)
Cynomolgus Monkey ENO1-493C Recombinant Cynomolgus ENO1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ENO1-238C-B Recombinant Cynomolgus Monkey ENO1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey ENO1-238C Recombinant Cynomolgus Monkey ENO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ENO1-1474R Recombinant Rhesus monkey ENO1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ENO1-1299R-B Recombinant Rhesus Macaque ENO1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ENO1-1299R Recombinant Rhesus Macaque ENO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken ENO1-6677C Recombinant Chicken ENO1 Mammalian Cell His
Kit-0324 ENO1 Human Activity Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ENO1 Related Articles
  • ENO1 Related Research Area

ENO1 involved in several pathways and played different roles in them. We selected most pathways ENO1 participated on our site, such as Glycolysis / Gluconeogenesis, Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ENO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisG6PC2;G6PC3;TPI1;ENO2;PGAM2;ADH7;LDHAL6A;pykF;MINPP1B
Metabolic pathwaysCYP2A12;DLAT;ACLY;AKR1C3;ACSL3;GAPDHS;QPRT;HMGCRB;TYRP1
Carbon metabolismHADHAB;HAO1;MCEE;ALDOA;SHMT2;ADPGK;GOT2;OGDHA;SHMT1
Biosynthesis of amino acidsPGAM1;ACO2;MAT2A;PYCR2;MAT2AA;GOT2;GLULA;ALDH7A1;PHGDH
RNA degradationENO3;PABPC5;BTG4;CNOT10;PFKL;CNOT3;LSM4;LSM2;EXOSC6
HIF- signaling pathwayMTOR;PRKCG;TCEB1;PRKCA;NOS3;EP300;PGK1;STAT3;NFKB1

ENO1 has several biochemical functions, for example, DNA binding, GTPase binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ENO1 itself. We selected most functions ENO1 had, and list some proteins which have the same functions with ENO1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingPOLR3H;ONECUTL;ZNF559;HMG20B;HIST1H3D;ZNF484;SAFB2;CMYB;ZNF729
GTPase bindingBNIP3;LCP1;PTPRN;RASA1;MARCH5;SH3GL1;STOML2;GNB1;YBX1
magnesium ion bindingCDC42BPB;ATP10A;GTPBP10;STK4;MAST4;ATP8B3;PRPS2;PPM1BA;THTPA
phosphopyruvate hydratase activityENO1B;ENO2;GM5506;ENO3;ENO1A;ENO1;ENO4
poly(A) RNA bindingPEG10;FKBP4;TRMT10C;SYF2;SRP54;SRPK2;PNN;RPS11;MAK16
protein bindingAHNAK;MPG;DHH;KIAA1530;WASF1;IKBKB;SMCO4;SDCBP2;C10orf33
transcription corepressor activityZHX3;CRYM;IRF2BP2;TRIM22;DDX54;AJUBA;DR1;HSF4;C1QBP
transcription factor activity, sequence-specific DNA bindingZKSCAN4;STAT4;HSF1;TP53;ZFP28;NR5A1B;FOXO3A;FOXN4;TSC22D4

ENO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ENO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ENO1.

YWHAZ; PCNA; VCAM1; ACHE; Akt2; 2-phospho-d-glyceric acid; PDE4DIP; MAP3K7; RIPK2; ACTB

Petit, FM; Serres, C; et al. Moonlighting proteins in sperm-egg interactions. BIOCHEMICAL SOCIETY TRANSACTIONS 42:1740-1743(2014).
Amedei, A; Niccolai, E; et al. Pancreatic cancer: Role of the immune system in cancer progression and vaccine-based immunotherapy. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3354-3368(2014).
  • Q&As
  • Reviews

Q&As (5)

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What are some of the cancers where ENO1 is overexpressed? 11/26/2022

ENO1 overexpression is seen in cancers like lung cancer, breast cancer, pancreatic cancer, and glioblastoma, among others.

Are there any diagnostic or therapeutic applications for ENO1 in infectious diseases? 04/17/2021

ENO1 in infectious agents may offer potential targets for diagnostic tests and treatments, although this field of research is still developing.

Are there any targeted therapies that focus on ENO1 in cancer treatment? 12/21/2018

Some research suggests that targeted therapies directed at ENO1 could be a potential strategy for cancer treatment, but more studies are needed.

Can ENO1 be used as a diagnostic marker for autoimmune diseases? 11/29/2016

ENO1 antibodies can be used as diagnostic markers for autoimmune diseases like celiac disease.

Are there diagnostic applications for ENO1 in neurodegenerative diseases? 10/09/2016

ENO1 may serve as a potential biomarker for the early diagnosis and monitoring of neurodegenerative diseases, although more research is needed.

Customer Reviews (3)

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Reviews
07/24/2021

    Its ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.

    03/30/2021

      the use of ENO1 protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.

      06/25/2020

        The manufacturer of ENO1 protein plays a crucial role in supporting my research endeavors.

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