ENO1
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Official Full Name
enolase 1, (alpha)
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Overview
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. -
Synonyms
ENO1; enolase 1, (alpha); ENO1L1, MPB1; alpha-enolase; c-myc promoter-binding protein-1; MBP 1; PPH; enolase-alpha; tau-crystallin; non-neural enolase; alpha enolase like 1; phosphopyruvate hydratase; plasminogen-binding protein; MYC promot;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- GMP Proteins
- Assay Kits
- Cattle
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Baculovirus-Insect cells
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- MAT
- Flag
- GST
- His
- His (Fc)
- Avi
- Strep
- His|Myc
- Myc
- DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- ENO1 Related Articles
- ENO1 Related Research Area
ENO1 involved in several pathways and played different roles in them. We selected most pathways ENO1 participated on our site, such as Glycolysis / Gluconeogenesis, Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ENO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycolysis / Gluconeogenesis | G6PC2;G6PC3;TPI1;ENO2;PGAM2;ADH7;LDHAL6A;pykF;MINPP1B |
Metabolic pathways | CYP2A12;DLAT;ACLY;AKR1C3;ACSL3;GAPDHS;QPRT;HMGCRB;TYRP1 |
Carbon metabolism | HADHAB;HAO1;MCEE;ALDOA;SHMT2;ADPGK;GOT2;OGDHA;SHMT1 |
Biosynthesis of amino acids | PGAM1;ACO2;MAT2A;PYCR2;MAT2AA;GOT2;GLULA;ALDH7A1;PHGDH |
RNA degradation | ENO3;PABPC5;BTG4;CNOT10;PFKL;CNOT3;LSM4;LSM2;EXOSC6 |
HIF- signaling pathway | MTOR;PRKCG;TCEB1;PRKCA;NOS3;EP300;PGK1;STAT3;NFKB1 |
ENO1 has several biochemical functions, for example, DNA binding, GTPase binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ENO1 itself. We selected most functions ENO1 had, and list some proteins which have the same functions with ENO1. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | POLR3H;ONECUTL;ZNF559;HMG20B;HIST1H3D;ZNF484;SAFB2;CMYB;ZNF729 |
GTPase binding | BNIP3;LCP1;PTPRN;RASA1;MARCH5;SH3GL1;STOML2;GNB1;YBX1 |
magnesium ion binding | CDC42BPB;ATP10A;GTPBP10;STK4;MAST4;ATP8B3;PRPS2;PPM1BA;THTPA |
phosphopyruvate hydratase activity | ENO1B;ENO2;GM5506;ENO3;ENO1A;ENO1;ENO4 |
poly(A) RNA binding | PEG10;FKBP4;TRMT10C;SYF2;SRP54;SRPK2;PNN;RPS11;MAK16 |
protein binding | AHNAK;MPG;DHH;KIAA1530;WASF1;IKBKB;SMCO4;SDCBP2;C10orf33 |
transcription corepressor activity | ZHX3;CRYM;IRF2BP2;TRIM22;DDX54;AJUBA;DR1;HSF4;C1QBP |
transcription factor activity, sequence-specific DNA binding | ZKSCAN4;STAT4;HSF1;TP53;ZFP28;NR5A1B;FOXO3A;FOXN4;TSC22D4 |
ENO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ENO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ENO1.
YWHAZ; PCNA; VCAM1; ACHE; Akt2; 2-phospho-d-glyceric acid; PDE4DIP; MAP3K7; RIPK2; ACTB
- Q&As
- Reviews
Q&As (5)
Ask a questionENO1 overexpression is seen in cancers like lung cancer, breast cancer, pancreatic cancer, and glioblastoma, among others.
ENO1 in infectious agents may offer potential targets for diagnostic tests and treatments, although this field of research is still developing.
Some research suggests that targeted therapies directed at ENO1 could be a potential strategy for cancer treatment, but more studies are needed.
ENO1 antibodies can be used as diagnostic markers for autoimmune diseases like celiac disease.
ENO1 may serve as a potential biomarker for the early diagnosis and monitoring of neurodegenerative diseases, although more research is needed.
Customer Reviews (3)
Write a reviewIts ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.
the use of ENO1 protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.
The manufacturer of ENO1 protein plays a crucial role in supporting my research endeavors.
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