Recombinant Human EPO, His-tagged
Cat.No. : | EPO-2291H |
Product Overview : | Recombinant human EPO protein, fused to His-tag at N-terminus, was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Description : | Erythropoietin, also known as EPO, is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine hormone composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. Overexpression of EPO is associated with several pathophysiological conditions, such as polycythemias vera, which is caused by the EPO -independent growth of erythrocytic progenitors from abnormal stem cells. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol |
Molecular Mass : | 20.9 kDa |
Protein length : | 189aa |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSAPPRLIC DSRVLERYLL EAKEAENITT GCAEHCSLNE NITVPDTKVN FYAWKRMEVG QQAVEVWQGLALLSEAVLRG QALLVNSSQP WEPLQLHVDK AVSGLRSLTT LLRALRAQKE AISPPDAASA APLRTITADT FRKLFRVYSN FLRGKLKLYT GEACRTGDR |
Purity : | >80% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml |
Gene Name : | EPO erythropoietin [ Homo sapiens ] |
Official Symbol : | EPO |
Synonyms : | EPO; erythropoietin; EP; epoetin; MVCD2; MGC138142; |
Gene ID : | 2056 |
mRNA Refseq : | NM_000799 |
Protein Refseq : | NP_000790 |
MIM : | 133170 |
UniProt ID : | P01588 |
Chromosome Location : | 7q21 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; EPO Receptor Signaling, organism-specific biosystem; EPO signaling pathway, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem; |
Function : | erythropoietin receptor binding; eukaryotic cell surface binding; hormone activity; protein binding; protein kinase activator activity; |
Products Types
◆ Recombinant Protein | ||
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EPO-1203P | Recombinant Pig EPO Protein, His-tagged | +Inquiry |
EPO-2521H | Recombinant Human EPO protein(28-193 aa), N-MBP-His-tagged | +Inquiry |
Epo-1847M | Recombinant Mouse Epo Protein | +Inquiry |
EPO-1312R | Recombinant Rhesus Macaque EPO Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
EPO-1450MCL | Recombinant Mouse EPO cell lysate | +Inquiry |
EPO-592RCL | Recombinant Rat EPO cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0327 | Eosinophil Peroxidase Fluorometric Detection Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionEPO protein can promote the renewal and repair of heart blood vessels, and has the effect of protecting the heart from ischemia-reperfusion damage.
By binding to receptors, EPO proteins activate signaling pathways that promote the proliferation and differentiation of hematopoietic stem cells in bone marrow into erythrocytes.
EPO protein can be used by injection or oral, and the specific method and dosage need to be determined according to the condition and the doctor's advice.
The study of EPO protein helps to understand the regulatory mechanism of erythropoiesis and provides new ideas and methods for the treatment of anemia, such as developing more effective EPO protein analogues or improving existing treatment regimens.
This protein stimulates the bone marrow to produce more red blood cells, thereby increasing hemoglobin levels and treating anemia.
In kidney disease, due to impaired kidney function, the production of EPO protein decreases, leading to anemia. Supplementation with exogenous EPO protein can help correct anemia caused by kidney problems.
Customer Reviews (3)
Write a reviewStability is truly remarkable, can maintain its activity even under extreme conditions.
Can catalyze reactions even under extreme conditions.
This protein's repeatability is truly exceptional, consistently delivering reliable results even under challenging conditions.
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