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Official Full Name endothelial cell-specific molecule 1
Background Endothelial cell-specific molecule 1 is a protein that in humans is encoded by the ESM1 gene. This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. The ESM-1 gene product is also called endocan since 2001, when it was characterized as a dermatan sulfate proteoglycan by Bechard et al. Recently, endocan/ESM-1 has been described as a specific biomarker of tip cells during neoangiogenesis by independent teams. Endocan expression has been shown to be increase in presence of pro-angiogenic growth factors such as VEGF (vascular endothelial growth factor) or FGF-2 (fibroblast growth factor 2). In hypervascularized cancers, overexpression of endocan has been detected by immunohistochemistry using monoclonal antibodies against endocan/ESM-1.
Synonyms ESM1; endocan; endothelial cell-specific molecule 1
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MBP
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ESM1-001HCL Recombinant Human ESM1 cell lysate Insect Cell N/A
    Human ESM1-189H Recombinant Human ESM1, His tagged Insect Cell His
    Human ESM1-3500H Recombinant Human ESM1 Protein, GST-tagged Wheat Germ GST
    Human ESM1-456H Recombinant Human ESM1 Protein, His-tagged HEK293 His
    Human ESM1-57H Recombinant Human ESM1 protein, T7/His-tagged E.coli T7/His
    Human ESM1-7082H Recombinant Human ESM1, His-tagged E.coli His
    Human ESM1-902H Recombinant Human Endothelial Cell-specific Molecule 1, His-tagged E.coli His
    Mouse ESM1-001MCL Recombinant Mouse ESM1 cell lysate Insect Cell N/A
    Mouse Esm1-476M Recombinant Mouse Endothelial Cell-Specific Molecule 1, His-tagged NS0 His
    Mouse Esm1-707M Recombinant Mouse Cebpd Protein, His/MBP-tagged E.coli His/MBP
    Mouse Esm1-708M Recombinant Mouse Cebpd Protein, His/GST-tagged E.coli His/GST
    Mouse Esm1-7412M Recombinant Mouse Esm1 Protein, His-tagged Insect Cell His
    Mouse Esm1-8703M Recombinant Mouse Esm1, His tagged Insect Cell His
    Rat ESM1-2149R Recombinant Rat ESM1 Protein Mammalian Cell His
    Rat Esm1-709R Recombinant Rat Esm1 Protein, His-tagged E.coli His
    Zebrafish ESM1-4577Z Recombinant Zebrafish ESM1 Mammalian Cell His

    esm1 involved in several pathways and played different roles in them. We selected most pathways esm1 participated on our site, such as Gastric cancer network 1, which may be useful for your reference. Also, other proteins which involved in the same pathway with esm1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gastric cancer network 1 ESM1; TOP2A; C21orf33; S100P; TPX2; SMOC2; ACTL6A; LIN9; MYBL2; GATS

    esm1 has several biochemical functions, for example, hepatocyte growth factor receptor binding, insulin-like growth factor binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by esm1 itself. We selected most functions esm1 had, and list some proteins which have the same functions with esm1. You can find most of the proteins on our site.

    Function Related Protein
    hepatocyte growth factor receptor binding ESM1; GLMN
    insulin-like growth factor binding WISP3; IGF1RA; KAZALD3; CTGF; HTRA4; NOV; CYR61; WISP1; CTGFB; IGFBP1B
    integrin binding NIPAL1; ADAM23; WISP2; WISP1; ITGA3; COL3A1; LAMA5; KDR; NF2; FBN1

    esm1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with esm1 here. Most of them are supplied by our site. Hope this information will be useful for your research of esm1.

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