| Description : |
This gene encodes a membrane-bound glycoprotein that forms the primary physiological initiator of the blood coagulation process following vascular damage. The encoded protein binds to coagulation factor VIIa and the ensuing complex catalyzes the proteolytic activation of coagulation factors IX and X. Mice lacking encoded protein die in utero resulting from massive hemorrhaging in both extraembryonic and embryonic vessels. A severe deficiency of the encoded protein in mice results in impaired uterine homeostasis, shorter life spans due to spontaneous fatal hemorrhages and cardiac fibrosis. |
| Species : |
Mouse |
| Tag : |
His |
| Form : |
Liquid |
| Molecular Mass : |
26.4 kDa |
| Protein length : |
29-251 |
| AA Sequence : |
ADPAGIPEKAFNLTWISTDFKTILE WQPKPTNYTYTVQISDRSRNWKNKC FSTTDTECDLTDEIVKDVTWAYEAK VLSVPRRNSVHGDGDQLVIHGEEPP FTNAPKFLPYRDTNLGQPVIQQFEQ DGRKLNVVVKDSLTLVRKNGTFLTL RQVFGKDLGYIITYRKGSSTGKKTN ITNTNEFSIDVEEGVSYCFFVQAMI FSRKTNQNSPGSSTVCTEQWKSFLG EHHHHHH |
| Endotoxin : |
< 1.0 EU/μg of protein (determined by LAL method) |
| Purity : |
> 95 % by SDS-PAGE |
| Stability : |
Shelf life: one year from despatch. |
| Storage : |
Store undiluted at 2-8 centigrade for one week or (in aliquots) at -20 to -80 centigrade for longer. Avoid repeated freezing and thawing. |
| Concentration : |
0.5 mg/mL (determined by absorbance at 280nm) |
| Storage Buffer : |
Phosphate Buffered Saline (pH 7.4) containing 10 % glycerol. |
