FOSL1
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Official Full Name
Fos-related antigen 1
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Overview
Fos-related antigen 1 is a protein that in humans is encoded by the FOSL1 gene. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. -
Synonyms
FLJ23306; Fos L2; FOS like antigen 2; Fos related antigen 2; Fos-related antigen 2; FosL 2; Fosl2; FOSL2; FRA 2; FRA-2; Fos-related antigen 1; FOSL1; FRA; FRA1; fra-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- FOSL1 Related Articles
FOSL1 involved in several pathways and played different roles in them. We selected most pathways FOSL1 participated on our site, such as Wnt signaling pathway, Osteoclast differentiation, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOSL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | PPP3CA;RUVBL1;SOX17;PPARD;FZD5;DVL3A;WNT2BA;FZD8A;RHOAA |
| Osteoclast differentiation | NOX3;LILRA1;CYLD;PPP3CC;FCGR2B;LCP2;IFNB1;NOX1;FCGR1A |
| HTLV-I infection | RELB;IL2RA;TBP;CALR;CD3D;HLA-DRB5;IL2RG;IKBKB;XPO1 |
FOSL1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding, transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOSL1 itself. We selected most functions FOSL1 had, and list some proteins which have the same functions with FOSL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NFATC4;TBX3;ELF1;HHEX;JUNBA;EBF1;EN1;SMAD4;MAFB |
| protein binding | SLC11A2;KCND2;ERO1LB;UBE2M;FAM92A;SH2D1A;MATK;TXNL4A;COL10A1 |
| transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | FOSL1A;CLOCK;BATF;BATF2;TFAP2A;RBPJB;FOSL1;FOSB;CREB3 |
| transcription factor activity, sequence-specific DNA binding | TBX1;HOXB3;CREB5;GLI2;SOX11;PBX3B;THRB;HOXB2A;FOXO1B |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | JUNB;TFAP2A;POU1F1;MEIS1;TCF4;CREB3L2;FOXC2;KCNA3;NFIB |
FOSL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOSL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOSL1.
NME7; LDOC1; JUN; USF1; CREB5
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, preclinical studies and early-phase clinical trials are exploring the potential synergistic effects of combining FOSL1 inhibitors with other targeted therapies to enhance treatment efficacy.
High expression levels of FOSL1 have been associated with poor prognosis and shorter overall survival in various cancer patients.
FOSL1 regulates the tumor microenvironment by promoting angiogenesis, immune evasion, and metastasis, thus contributing to cancer progression and spread.
Although the specific side effects may vary, common adverse effects of FOSL1-targeted therapies may include gastrointestinal disturbances, fatigue, and immunological reactions.
Dysregulated FOSL1 expression can disrupt cellular homeostasis, leading to uncontrolled cell proliferation, evasion of cell death, and genomic instability, all of which contribute to tumorigenesis.
Customer Reviews (3)
Write a reviewThis reliable supply chain management assures that I have uninterrupted access to the protein, allowing me to plan and conduct my experiments without concern for availability issues.
They ensure a reliable and consistent supply of FOSL1 protein, minimizing any potential disruptions in my experimental workflow.
They ensure a reliable and consistent supply of FOSL1 protein, minimizing any potential disruptions in my experimental workflow.
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