gcgr

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gcgr

Official Full Name glucagon receptor
Background The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).
Synonyms GCGR; glucagon receptor; GGR; GL R; GL-R; GLR; GLR_HUMAN; Glucagon receptor precursor; MGC138246
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Yeast
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GCGR-001H Recombinant Human GCGR Protein, His-tagged E.coli His
    Human GCGR-5989HCL Recombinant Human GCGR 293 Cell Lysate HEK293 N/A
    Mouse GCGR-2338M Recombinant Mouse GCGR Protein (27-143 aa), His-tagged Yeast His
    Mouse GCGR-518M Recombinant Mouse GCGR Protein (27-143 aa), GST-tagged E.coli GST
    Rat GCGR-2488R Recombinant Rat GCGR Protein Mammalian Cell His
    Kit-1027 Phospho-ERK1/2 (Thr202/Tyr204) Translocation Assay Kit (Cell-Based) N/A
    Kit-1029 Total Collagen Assay Kit (Colorimetric) N/A
    Kit-1249 GCGR Total GPCR Internalization Assay Kit N/A
    Kit-1250 GCGR CHO-K1 β-Arrestin GPCR Assay Kit N/A
    Kit-1251 CHO-K1 GCGR Bioassay Kit N/A
    Kit-1252 cAMP GCGR CHO-K1 GPCR Assay Kit N/A
    Kit-1253 GCGR CHO-K1 β-Arrestin-1 GPCR Assay Kit N/A

    gcgr involved in several pathways and played different roles in them. We selected most pathways gcgr participated on our site, such as Neuroactive ligand-receptor interaction, Glucagon signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with gcgr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuroactive ligand-receptor interaction PRLRA; GH2; GRID2; LHB; KISS1R; ADRA2DA; HCRTR2; CSH2; CHRND; PRLHR2A
    Glucagon signaling pathway FBP1; SLC2A2; LDHAL6B; CRTC2; CPT1C; PDHA2; CALML3; LDHA; PDHA1; PPARA

    gcgr has several biochemical functions, for example, glucagon receptor activity, guanyl-nucleotide exchange factor activity, peptide hormone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by gcgr itself. We selected most functions gcgr had, and list some proteins which have the same functions with gcgr. You can find most of the proteins on our site.

    Function Related Protein
    glucagon receptor activity GLP1R; GLP2R; GCGR
    guanyl-nucleotide exchange factor activity ARFGEF1; RAPGEF6; BCAR3; ITSN1; RAPGEF3; FGD3; ARHGEF39; RALGPS2; DOCK4B; VAV3
    peptide hormone binding AGTR2; OXTR; ACVR1; HCRTR2; GALR1; MC3R; GALR3; AVPR1A; AGTR1A; PTH1R

    gcgr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with gcgr here. Most of them are supplied by our site. Hope this information will be useful for your research of gcgr.

    PSMD2; Hacd3; TGM2; TP63

    Jun, LS; Millican, RL; et al. Absence of Glucagon and Insulin Action Reveals a Role for the GLP-1 Receptor in Endogenous Glucose Production. DIABETES 64:819-827(2015).
    Wang, MY; Yan, H; et al. Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:2503-2508(2015).

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