GIPR
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Official Full Name
gastric inhibitory polypeptide receptor
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Overview
Gastric Inhibitory Polypeptide Receptor is a member of the G protein-coupled receptor (GPCR, or GPR) family (subfamily Gastric inhibitory polypeptide). Members of this family contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. Gastric inhibitory polypeptide receptor is a receptor for gastric inhibitory polypeptide (GIP), this is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response. GIPR expression has been reported in human bone, fetal adrenal, and pancreas. Little expression has been identified in normal adult adrenal, but overexpression of GIPR has been observed in the adrenal in food- dependent Cushing's syndrome. GIPR expression has been identified in rat brain, heart, pancreas, and small intestine. ESTs have been isolated from colon libraries. -
Synonyms
GIPR; gastric inhibitory polypeptide receptor; PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor; MGC126722; GIP; Gastric Inhibitory Peptide;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Homo sapiens (Human)
- Human
- Mesocricetus auratus (Golden hamster)
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In vitro E. coli expression system
- Insect Cell
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Flag
- Myc
- MBP
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- GIPR Related Articles
GIPR involved in several pathways and played different roles in them. We selected most pathways GIPR participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GIPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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cAMP signaling pathway | LOC100328615;RHOA;ATP2A2;CREB3L3;PLCE1;PPP1R12A;PLD1;PDE4B;NFKB1 |
Neuroactive ligand-receptor interaction | NMUR1;GLRA1;CCKAR;NPFFR2;GNRHR2;APLNRA;OPRM1;MC5RA;HTR1E |
GIPR has several biochemical functions, for example, gastric inhibitory peptide receptor activity, peptide hormone binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GIPR itself. We selected most functions GIPR had, and list some proteins which have the same functions with GIPR. You can find most of the proteins on our site.
Function | Related Protein |
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gastric inhibitory peptide receptor activity | |
peptide hormone binding | NPR3;CRHR2;NPR2;PTH1RB;AGTR1B;GHRHR;GALR1;GHSR;GIPR |
transmembrane signaling receptor activity | BAI2;TLR5;KLRF1;EGFR;SLAMF1;FZD8A;MARCO;OR6K3;LGR4 |
GIPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GIPR here. Most of them are supplied by our site. Hope this information will be useful for your research of GIPR.
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