hdac5
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  • Official Full Name
  • histone deacetylase 5
  • Background
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • HDAC5; histone deacetylase 5; FLJ90614; KIAA0600; NY CO 9; antigen NY-CO-9; HD5; NY-CO-9
Cat.#:HDAC5-4647HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDAC5 Protein, GST-tagged
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Cat.#:Hdac5-1593MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Mouse Histone Deacetylase 5, GST-tagged
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Cat.#:HDAC5-396HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 5, GST-tagged
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Cat.#:HDAC5-96HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human HDAC5 Protein, His-tagged
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Cat.#:HDAC5-2055RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HDAC5 Protein, His-tagged
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Cat.#:HDAC5-1358MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse HDAC5 (Active), GST-tagged
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Cat.#:HDAC5-5604HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HDAC5 293 Cell Lysate
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Cat.#:Kit-1741Tag:
Source (Host):Species:
Product nameHDAC5 Fluorogenic Assay Kit
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Involved Pathway

HDAC5 involved in several pathways and played different roles in them. We selected most pathways HDAC5 participated on our site, such as Alcoholism, B Cell Receptor Signaling Pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alcoholism
HIST1H2AO; HIST2H2AA4; GRIN2A; SOS1; GM14483; HIST1H2BJ; GRIN2C; HDAC2; HDAC3; HIST2H3A
B Cell Receptor Signaling Pathway
CTNNB2; VAV1; HRAS; PPP3CA; IGHM; ARPC1B; MAP4K1; NEDD9; MAP2K1; RAF1
Cell cycle
MIS18A; CDK6; MIS18BP1; MPEG1.1; CENPL; NEK2; CENPJ; BRCC3; RAD9A; YWHAB
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
CDK8; JAG1; HEYL; HEY2; ADAM10; HDAC5; CCNC; HDAC6; MIB1; JAG2
Constitutive Signaling by NOTCH1 PEST Domain Mutants
CCNC; HDAC5; JAG2; CDK8; ADAM10; MIB1; HDAC6; JAG1; HEY2; HEYL
Disease
SFTPC; HDAC6; STRA6; RPL35; TAF1L; MIB1; FMOD; RNF43; CDK9; CCNC
Diseases of signal transduction
RNF43; TTR; TRAT1; CCNC; CTBP2; HEY2; OS9; MIB1; RBP1; FGFR1OP
Epstein-Barr virus infection
TBPL2; RB1; HDAC2; POLR2G; EIF2AK1; POLR3H; IRAK1; MAP3K7; PSMD1; ITGAL

Protein Function

HDAC5 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), RNA polymerase III transcription factor binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC5 itself. We selected most functions HDAC5 had, and list some proteins which have the same functions with HDAC5. You can find most of the proteins on our site.
Function
Related Protein
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC7; HDAC3; HDAC7A; HDAC2; HDAC4; HDAC6; HDAC9; HDAC9B; HDAC8; HDAC10
Function RNA polymerase III transcription factor binding
Related Protein HDAC5; HDAC4
Function chromatin binding
Related Protein NAP1L2; HDGFRP2; SMAD2; EP300; SIRT6; HMGB1A; NEUROD1; APITD1; BRD4; CUX1
Function core promoter binding
Related Protein GATA1; GADD45A; SPI1; NKX3; ARNTL; HDAC1; NEUROG3; INSM1A; CCAR1; PSPC1
Function histone deacetylase activity
Related Protein HDAC9; SIRT2; HDAC3; HDAC6; SIRT1; HDAC10; HDAC11; HDAC1; ATXN3L; HDAC2
Function histone deacetylase binding
Related Protein NUDT21; KAT2A; ANKRA2; MYOCD; RUNX2; KLF4; SFPQ; KAT2B; RFXANK; PKN1
Function metal ion binding
Related Protein ZIC4; CAR1; UNC13B; ZFPM2; ZDHHC15A; FTH1B; GALNT18A; NUDT19; ATMIN; LHX8
Function protein binding
Related Protein C17orf59; FSTL3; TUBA1C; SOCS2; PPP2R5B; SEPT5; RIOK3; NDUFA9; CD5; NEUROG1
Function protein deacetylase activity
Related Protein HDAC9; HDAC10; HDAC5; SIRT1; HDAC4; HDAC1; SIRT2; SIN3A; HDAC2; HDAC3
Function protein kinase C binding
Related Protein PKP2; PARD6A; C1QBP; AKT2; PLEK; PARD3; AVPR1B; HINT1; LDB3; FEZ1
Function repressing transcription factor binding
Related Protein RELA; TBP; EIF4E; ARNTL; DDX20; HDAC7; HDAC7A; HHEX; MAGEA2; HDAC1
Function transcription corepressor activity
Related Protein ALX1; HOXC6; NFIL3; NCOR2; IRF2BP2; MXD1; RARA; NR0B2; SSX4; TBL1Y
Function transcription factor binding
Related Protein STK36; CREBBP; RPS3; PRICKLE1; MYOD1; HOXA7; NFYC; CHCHD2; ID1; NFKB1
Function contributes_to transcription regulatory region DNA binding
Related Protein ATF4; NFYC; NR1H3; RXRA; TCF3; HAND1; HDAC4; TCF12; HDAC5; NFYB

Interacting Protein

HDAC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC5.
YWHAZ; SFN; YWHAB; YWHAE; ICP0; BRMS1; RUNX3

HDAC5 Related Articles

Chang, CW; Cheong, ML; et al. Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion. MOLECULAR HUMAN REPRODUCTION 19:745-755(2013).
Maxwell, JT; Natesan, S; et al. Modulation of Inositol 1,4,5-Trisphosphate Receptor Type 2 Channel Activity by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII)-mediated Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 287:-(2012).