hdac5
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  • Official Full Name
  • histone deacetylase 5
  • Background
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • HDAC5; histone deacetylase 5; FLJ90614; KIAA0600; NY CO 9; antigen NY-CO-9; HD5; NY-CO-9
Cat.#:HDAC5-312HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human HDAC5 Protein
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Cat.#:HDAC5-4647HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDAC5 Protein, GST-tagged
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Cat.#:Hdac5-1593MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Mouse Histone Deacetylase 5, GST-tagged
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Cat.#:HDAC5-396HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Histone Deacetylase 5, GST-tagged
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Cat.#:HDAC5-96HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human HDAC5 Protein, His-tagged
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Cat.#:HDAC5-2055RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HDAC5 Protein, His-tagged
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Cat.#:HDAC5-1358MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse HDAC5 (Active), GST-tagged
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Cat.#:HDAC5-5604HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HDAC5 293 Cell Lysate
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Cat.#:Kit-1741Tag:
Source (Host):Species:
Product nameHDAC5 Fluorogenic Assay Kit
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Involved Pathway

HDAC5 involved in several pathways and played different roles in them. We selected most pathways HDAC5 participated on our site, such as Alcoholism, B Cell Receptor Signaling Pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alcoholism
HDAC8; H2AFB1; CALM4; HDAC1; H2AFJ; GRIN1; HIST2H3C2; GRIN3B; GM14478; H2AFX
B Cell Receptor Signaling Pathway
CDK6; CD19; FCGR2B; BCL10; LAT2; NFATC3; MAP4K1; CDK2; MAPK4; PILRB
Cell cycle
LMNB1; CDC23; GADD45G; TUBB4A; CEP152; WAPAL; NINL; CENPO; SMC4; LIN9
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HEYL; ADAM10; HDAC6; MIB1; CCNC; HEY1; HEY2; CDK8; JAG1; JAG2
Constitutive Signaling by NOTCH1 PEST Domain Mutants
HEYL; JAG2; HEY2; MIB1; HDAC6; CDK8; ADAM10; CCNC; HDAC5; HEY1
Disease
FGFR1OP2; STX1B; MMAA; AP2S1; SSRP1; HEY2; SFTPC; EPM2A; DOCK2; STRA6
Diseases of signal transduction
TNKS; KREMEN1; FGFR1OP; RLBP1; OPN1SW; RBP4; RNF43; CTBP1; CDC37; CUX1
Epstein-Barr virus infection
PRKACA; PSMD13; H2-Q10; CSNK2A2; ENTPD3; PIK3CB; HSPB2; ENTPD8; POLR1C; HLA-DRB1

Protein Function

HDAC5 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), RNA polymerase III transcription factor binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC5 itself. We selected most functions HDAC5 had, and list some proteins which have the same functions with HDAC5. You can find most of the proteins on our site.
Function
Related Protein
Function NAD-dependent histone deacetylase activity (H3-K14 specific)
Related Protein HDAC9; HDAC3; HDAC2; HDAC4; HDAC1; HDAC9B; HDAC10; HDAC11; HDAC5; HDAC8
Function RNA polymerase III transcription factor binding
Related Protein HDAC5; HDAC4
Function chromatin binding
Related Protein RBMX; LDB2A; SIN3B; MNT; RBPJ; EZH2; POLG; SETD7; HIF1AB; SSBP1
Function core promoter binding
Related Protein HDAC6; HNRNPU; E2F8; NEUROG3; MTF1; GATA1; GADD45A; MED1; E2F2; AGO2
Function histone deacetylase activity
Related Protein HDAC9B; NACC2; ATXN3L; HDAC4; HDAC11; HDAC9; HDAC6; HDAC5; HDAC1; HDAC2
Function histone deacetylase binding
Related Protein ZNHIT1; GMNN; HOXA10; HDAC10; DDX20; ZNF703; HIF1A; USF1; HIST1H1B; YY1
Function metal ion binding
Related Protein ZNF613; ZNF285A; MICAL2B; ZNF133; ZDHHC8B; ADCY7; ADH8A; VAV1; ZNF280D; RNF169
Function protein binding
Related Protein FOXG1; CTLA4; AURKA; COPS6; ZNF543; STAU2; ZNF385C; ZZZ3; ST8SIA5; ASUN
Function protein deacetylase activity
Related Protein SIRT1; HDAC2; SIRT2; HDAC5; SIN3A; HDAC10; HDAC4; HDAC3; HDAC9; HDAC1
Function protein kinase C binding
Related Protein FLNA; AKT2; HINT1; IRS1; TOP2B; DSP; TDG; PKP2; HSPB1; NELL2
Function repressing transcription factor binding
Related Protein RUNX2; PRDM5; EIF4E; CTNNB1; SKI; KAT5; NFYB; HDAC7; NOC2L; DDX20
Function transcription corepressor activity
Related Protein ZHX1; ATF5; SKOR2; FOXP3; LOXL2; LMCD1; SAP30; ASXL1; KLF12; ZFPM2
Function transcription factor binding
Related Protein PIAS2; FOXA2; GPX3; SLC26A5; NKX2; MYOCD; ADD1; RNF222; SIRT2; UBE2I
Function contributes_to transcription regulatory region DNA binding
Related Protein TCF12; HAND1; HDAC4; ATF4; NFYA; NFYC; NFYB; NR1H3; RXRA; HDAC5

Interacting Protein

HDAC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC5.
YWHAZ; SFN; YWHAB; YWHAE; ICP0; BRMS1; RUNX3

HDAC5 Related Articles

Chang, CW; Cheong, ML; et al. Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion. MOLECULAR HUMAN REPRODUCTION 19:745-755(2013).
Maxwell, JT; Natesan, S; et al. Modulation of Inositol 1,4,5-Trisphosphate Receptor Type 2 Channel Activity by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII)-mediated Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 287:-(2012).