Recombinant Human HDAC5 Protein, GST-tagged

• Cat.No.: HDAC5-4647H
• Product Overview: Human HDAC5 partial ORF ( AAH51824, 330 a.a. - 429 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 36.63 kDa
• AA Sequence: AENGFTGSVPNIPTEMLPQHRALPL DSSPNQFSLYTSPSLPNISLGLQAT VTVTNSHLTASPKLSTQQEAERQAL QSLRQGGTLTGKFMSTSSIPGCLLG
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: HDAC5 histone deacetylase 5 [ Homo sapiens ]
• Official Symbol: HDAC5
• Synonyms: HDAC5; histone deacetylase 5; FLJ90614; KIAA0600; NY CO 9; antigen NY-CO-9; HD5; NY-CO-9
• Gene ID: 10014
• mRNA Refseq: NM_001015053
• Protein Refseq: NP_001015053
• MIM: 605315
• UniProt ID: Q9UQL6