Active Recombinant Human Histone Deacetylase 5, GST-tagged
Cat.No. : | HDAC5-396H |
Product Overview : | Full Length Human HDAC5–Class IIa, 150kD with GST tag. |
Availability | February 16, 2025 |
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Cat. No. : | HDAC5-396H |
Description : | Histone deacetylase 5, also known as HDAC5, is a human gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. |
Source : | HDAC5 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system. |
Purity : | Purified, active enzyme. |
Purification Procedure : | Glutathione Column |
Activity : | 1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C. |
Stability/Shelf-life : | >6 months from date of shipment |
Buffer Composition : | 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol. |
Storage : | –80°C |
Publication : |
Functional interaction of histone deacetylase 5 (HDAC5) and lysine-specific demethylase 1 (LSD1) promotes breast cancer progression (2017)
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Gene Name : | HDAC5 histone deacetylase 5 [ Homo sapiens ] |
Synonyms : | HDAC5; FLJ90614; HD5; NY-CO-9; HDAC5 histone deacetylase 5; histone deacetylase 5; antigen NY-CO-9; EC 3.5.1.98; KIAA0600; Antigen NY-CO-9. |
Gene ID : | 10014 |
mRNA Refseq : | NM_001015053 |
Protein Refseq : | NP_001015053 |
MIM : | 605315 |
UniProt ID : | Q9UQL6 |
Chromosome Location : | 17q21 |
Pathway : | Gene Expression |
Function : | histone deacetylase activity; hydrolase activity; specific transcriptional repressor activity; transcription corepressor activity; transcription factor binding |
Products Types
◆ Recombinant Protein | ||
HDAC5-312H | Active Recombinant Human HDAC5 Protein | +Inquiry |
HDAC5-4647H | Recombinant Human HDAC5 Protein, GST-tagged | +Inquiry |
HDAC5-164H | Recombinant Human HDAC5 Protein, His-tagged | +Inquiry |
HDAC5-1876R | Recombinant Rhesus Macaque HDAC5 Protein, His (Fc)-Avi-tagged | +Inquiry |
HDAC5-48H | Recombinant Human HDAC5 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
HDAC5-5604HCL | Recombinant Human HDAC5 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1741 | HDAC5 Fluorogenic Assay Kit | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThe HDAC5 they produce is of guaranteed quality, and we can rest assured that we buy it.
It performs well in ELISA and is very suitable for immunoassays.
It has strong antibacterial activity and is not easy to be contaminated.
Q&As (6)
Ask a questionIt has been linked to a variety of neurological diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, etc. It influences the development of these diseases by regulating the function and survival of neurons.
This is also associated with cardiovascular disease. Studies have shown that HDAC5 can regulate the function and survival of the heart, influencing the development of heart disease.
HDAC5 is associated with a variety of diseases, including cancer, neurological diseases, cardiovascular diseases, etc.
The activity of HDAC5 is regulated by a variety of factors, including intracellular signaling, transcription factors, and other proteases.
HDAC5 inhibitors can enhance the sensitivity of tumor cells and improve the effectiveness of chemotherapy or radiotherapy. In addition, it can also inhibit the migration and invasion of tumor cells.
This protein plays an important role in cancer, affecting the occurrence and progression of tumors by regulating the expression of tumor suppressor genes and tumor progenes.
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