Creative BioMart to Present at BPS 2025 Annual Meeting | February 15-19, 2025

Active Recombinant Human Histone Deacetylase 5, GST-tagged

Cat.No. : HDAC5-396H
Product Overview : Full Length Human HDAC5–Class IIa, 150kD with GST tag.
Availability February 16, 2025
Unit
Price
Qty
  • Specification
  • Gene Information
  • Related Products
  • Download
Cat. No. : HDAC5-396H
Description : Histone deacetylase 5, also known as HDAC5, is a human gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
Source : HDAC5 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.
Purity : Purified, active enzyme.
Purification Procedure : Glutathione Column
Activity : 1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C.
Stability/Shelf-life : >6 months from date of shipment
Buffer Composition : 25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol.
Storage : –80°C
Publication :
Functional interaction of histone deacetylase 5 (HDAC5) and lysine-specific demethylase 1 (LSD1) promotes breast cancer progression (2017)
Gene Name : HDAC5 histone deacetylase 5 [ Homo sapiens ]
Synonyms : HDAC5; FLJ90614; HD5; NY-CO-9; HDAC5 histone deacetylase 5; histone deacetylase 5; antigen NY-CO-9; EC 3.5.1.98; KIAA0600; Antigen NY-CO-9.
Gene ID : 10014
mRNA Refseq : NM_001015053
Protein Refseq : NP_001015053
MIM : 605315
UniProt ID : Q9UQL6
Chromosome Location : 17q21
Pathway : Gene Expression
Function : histone deacetylase activity; hydrolase activity; specific transcriptional repressor activity; transcription corepressor activity; transcription factor binding

Not For Human Consumption!

Inquiry

  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
02/22/2022

    The HDAC5 they produce is of guaranteed quality, and we can rest assured that we buy it.

    12/22/2021

      It performs well in ELISA and is very suitable for immunoassays.

      02/13/2020

        It has strong antibacterial activity and is not easy to be contaminated.

        Q&As (6)

        Ask a question
        Is there a relationship between HDAC5 and neurological diseases? 11/26/2022

        It has been linked to a variety of neurological diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, etc. It influences the development of these diseases by regulating the function and survival of neurons.

        What is the link between HDAC5 and cardiovascular disease? 04/17/2022

        This is also associated with cardiovascular disease. Studies have shown that HDAC5 can regulate the function and survival of the heart, influencing the development of heart disease.

        What is the relationship between HDAC5 and disease? 04/17/2022

        HDAC5 is associated with a variety of diseases, including cancer, neurological diseases, cardiovascular diseases, etc.

        How is HDAC5 activity regulated? 02/08/2021

        The activity of HDAC5 is regulated by a variety of factors, including intracellular signaling, transcription factors, and other proteases.

        Do HDAC5 inhibitors have a role in treatment? 07/07/2020

        HDAC5 inhibitors can enhance the sensitivity of tumor cells and improve the effectiveness of chemotherapy or radiotherapy. In addition, it can also inhibit the migration and invasion of tumor cells.

        Which role of HDAC5 in cancer? 01/21/2020

        This protein plays an important role in cancer, affecting the occurrence and progression of tumors by regulating the expression of tumor suppressor genes and tumor progenes.

        Ask a Question for All HDAC5 Products

        Required fields are marked with *

        My Review for All HDAC5 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2025 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends