Active Recombinant Mouse HDAC5, GST-tagged

• Cat.No.: HDAC5-1358M
• Product Overview: Recombinant mouse HDAC5 (617-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Mouse
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 617 aa-end
• Description: HDAC5 or Histone deacetylase 5 belongs to the class II histone deacetylase/acuc/apha family that possesses histone deacetylase activity and represses transcription when tethered to a promoter. HDAC 5 plays a critical role in transcriptional regulation, cell cycle progression, and developmental events and also acts as a potential therapeutic target for the prevention of atherosclerosis. HDAC5 can co-immunoprecipitates with HDAC3 family members forming multicomplex proteins. HDAC5 can also interact with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. HDAC5 gene is thought to be associated with colon cancer.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 110 RLU/min/ng
• Molecular Mass: ~80 kDa
• Purity: >90%
• Applications: HDAC Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: Hdac5 histone deacetylase 5 [ Mus musculus ]
• Official Symbol: HDAC5
• Synonyms: HDAC5; histone deacetylase 5; HD5; histone deacetylase 4; histone deacetylase mHDA1; Hdac4; mHDA1; AI426555; mKIAA0600
• Gene ID: 15184
• mRNA Refseq: NM_001077696
• Protein Refseq: NP_001071164
• Pathway: B Cell Receptor Signaling Pathway, organism-specific biosystem; Cell cycle, organism-specific biosystem; MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; estrogen signalling, organism-specific biosystem
• Function: histone deacetylase activity; hydrolase activity; protein binding; protein kinase C binding; repressing transcription factor binding; transcription corepressor activity; transcription corepressor activity; transcription factor binding