Human HSPB8 Knockdown Cell Lysate

• Cat.No.: HSPB8-011HKCL
• Product Overview: WB-validated HSPB8 Knockdown 293T Cell Lysate

Specification

• Species: Human
• Source: 293T
• Tag: Non
• Description: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 22 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type 293T cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT 293T cell lysate 1 vial of 100 μg HSPB8 KD 293T cell lysate
• Protein Families: Druggable Genome, Protein Kinase
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: HSPB8 heat shock 22kDa protein 8 [ Homo sapiens (human) ]
• Official Symbol: HSPB8
• Synonyms: HSPB8; heat shock 22kDa protein 8; heat shock 27kDa protein 8; heat shock protein beta-8; E2IG1; H11; HSP22; HspB8; protein kinase H11; alpha-crystallin C chain; E2-induced gene 1 protein; small stress protein-like protein HSP22; HMN2; CMT2L; DHMN2; HMN2A
• Gene ID: 26353
• mRNA Refseq: NM_014365
• Protein Refseq: NP_055180
• MIM: 608014
• UniProt ID: Q9UJY1