Ifnar1
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Official Full Name
interferon (alpha, beta and omega) receptor 1
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Overview
The antibody when prepared specifically for In vivo functional assays blocks type I IFN receptor signaling both In vitro and In vivo without depleting IFNAR1 bearing cells. This antibody was produced by In vivo genetic immunization of IFNAR1 knockout mice This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. -
Synonyms
IFNAR1; interferon (alpha, beta and omega) receptor 1; IFNAR; interferon alpha/beta receptor 1; IFRC; CRF2-1; IFN-R-1; IFN-alpha/beta receptor 1; interferon-beta receptor 1; beta-type antiviral protein; alpha-type antiviral protein; type I interferon rece; AVP; RF2-1; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; human interferon-alpha receptor (HuIFN-alpha-Rec); IFN-alpha-REC; IFNBR; interferon-alpha/beta receptor alpha chain; nterferon-beta receptor 1; TTHUMP00000067672; FRC; type I interferon receptor 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Therapeutic Proteins
- Protein Pre-coupled Magnetic Beads
- Ala25-Lys437
- Chicken
- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rhesus
- C-His
- E. coli
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Myeloma cell line
- Wheat Germ
- C
- His
- Avi
- Fc
- LEVLFQ
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | IFNAR1-508H | Recombinant Human IFNAR1 Protein, Fc-tagged | HEK293 | Fc | Met1-Lys436 |
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| Human | IFNAR1-188H | Recombinant Human IFNAR1 protein, Fc-tagged | HEK293 | Fc | Lys28-Lys436 |
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| Human | IFNAR1-29420TH | Recombinant Human IFNAR1 | Wheat Germ | Non | 100 amino acids |
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| Human | IFNAR1-28344TH | Recombinant Human IFNAR1 | Wheat Germ | Non | 557 amino acids |
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| Human | IFNAR1-509H | Recombinant Human IFNAR1 protein, His-tagged | HEK293 | His | Met1-Lys436 |
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| Human | IFNAR1-946H | Recombinant Human IFNAR1 Protein, His-tagged | HEK293 | His |
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| Human | IFNAR1-6938H | Recombinant Human IFNAR1 protein, His-tagged | E.coli | His | Leu25~Ser146 |
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| Human | IFNAR1-1643HCL | Recombinant Human IFNAR1 cell lysate | Human Cell | Non |
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| Human | IFNAR1-181HB | Recombinant Human IFNAR1 protein, His-Avi-tagged, Biotinylated | HEK293 | C-His-Avi | Lys28-Lys436 |
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| Human | IFNAR1-181H | Recombinant Human IFNAR1 protein, His-Avi-tagged | HEK293 | C-His-Avi | Lys28-Lys436 |
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| Human | IFNAR1-11H | Active Recombinant Human IFNAR1 Protein | Myeloma cell line | Gly26-Lys436 |
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| Human | IFNAR1-250HF | Recombinant Full Length Human IFNAR1 Protein | In Vitro Cell Free System | 557 amino acids |
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| Human | IFNAR1-3262H | Recombinant Human IFNAR1 protein, His-tagged | E.coli | His | ||
| Human | IFNAR1-2509H | Recombinant Human IFNAR1 Protein (Lys28-Lys436), C-His tagged | Mammalian cells | His | Lys28-Lys436 |
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| Human | IFNAR1-4251H | Recombinant Human IFNAR1 Protein (Met1-Lys436), C-His tagged | Mammalian cells | His | Met1-Lys436 |
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| Human | IFNAR1-4424H | Recombinant Human IFNAR1 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Human | IFNAR1-294H | Recombinant Human IFNAR1 Protein, Fc-tagged | HEK293 | Fc | 557 |
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| Human | IFNAR1-2510H | Recombinant Human IFNAR1 Protein (Lys28-Asn227), N-His tagged | E.coli | His | Lys28-Asn227 |
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| Human | IFNAR1-P004H | Recombinant Human IFNAR1 therapeutic protein(Peginterferon alfa-2a) | E.coli | Non | 165aa |
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| Human | IFNAR1-4424H-B | Recombinant Human IFNAR1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Human | IFNAR1-3263H | Recombinant Human IFNAR1 protein(458-557 aa), His-tagged | E. coli | His | 458-557 aa |
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| Human | IFNAR1-001H | Recombinant Human IFNAR1 Protein | Mammalian cells | Non |
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| Mouse | Ifnar1-3360M | Active Recombinant Mouse Ifnar1 protein, His-tagged | HEK293 | His | Met1-Thr429 | |
| Mouse | Ifnar1-6939M | Recombinant Mouse Ifnar1 protein, His-tagged | E.coli | His | Arg104~Thr341 |
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| Mouse | IFNAR1-2372MCL | Recombinant Mouse IFNAR1 cell lysate | Human Cell | Non |
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| Rat | Ifnar1-6940R | Recombinant Rat Ifnar1 protein, His-tagged | E.coli | His | Val90~Arg358 |
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| Ala25-Lys437 | IFNAR1-1407C | Recombinant Cynomolgus IFNAR1 protein, His-tagged | C-His | Ala25-Lys437 |
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| Cynomolgus Monkey | IFNAR1-78C | Recombinant Cynomolgus IFNAR1, Fc tagged | Human Cell | His | Met1-Lys437 |
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| Cynomolgus Monkey | IFNAR1-80C | Recombinant Cynomolgus IFNAR1, LEVLFQ tagged | Human Cell | His | Met1-Lys437 |
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| Cynomolgus Monkey | IFNAR1-816CCL | Recombinant Cynomolgus IFNAR1 cell lysate | Human Cell | Non |
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| Homo sapiens (Human) | RFL23097HF | Recombinant Full Length Human Interferon Alpha/Beta Receptor 1(Ifnar1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (28-557) |
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| Mus musculus (Mouse) | RFL14339MF | Recombinant Full Length Mouse Interferon Alpha/Beta Receptor 1(Ifnar1) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (27-590) |
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| Rhesus | IFNAR1-2205R | Recombinant Rhesus IFNAR1 Protein, His-tagged | HEK293 | His | Met1-Lys436 |
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| Rhesus | IFNAR1-2206R | Recombinant Rhesus IFNAR1 Protein, LEVLFQ-tagged | HEK293 | LEVLFQ | Met1-Lys437 |
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| Rhesus | IFNAR1-096R | Recombinant Rhesus IFNAR1 protein, hFc-tagged | HEK293 | Fc | Met1-Lys437 |
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| Rhesus | IFNAR1-1175R | Recombinant Rhesus IFNAR1 protein(Met1-Lys437) | HEK293 | Non | Met1-Lys437 |
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| Chicken | IFNAR1-6422C | Recombinant Chicken IFNAR1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- Ifnar1 Related Signal Pathway
Ifnar1 involved in several pathways and played different roles in them. We selected most pathways Ifnar1 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ifnar1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | FLT4;IFNA5;Ccl27a;CCL24;Il4ra;ACVR1BA;IFNPHI3;GHRA;CCR1L1 |
| PIK-Akt signaling pathway | ITGB5;LPAR2;PCK2;ANGPT4;NFKB1;PIK3R3;ITGB7;RHEB;FGF6 |
| Osteoclast differentiation | IL1R1;FOSL1;TEC;NCF1;CYBB;PIK3CD;IFNAR2;SYK;TAB2 |
| Toll-like receptor signaling pathway | NFKBIAA;CCL5;CCL3L3;FADD;TLR5B;IFNA17;IFNA2;IRAK1;MAPK3 |
| Jak-STAT signaling pathway | IFNGR2;IL13RA2;IFNA8;HRAS;IL20RB;CISHB;AOX2P;STAM2;IFNA10 |
| Natural killer cell mediated cytotoxicity | PRKCA;GRB2;RAF1;FCGR3A;TYROBP;KIR2DL4;Casp3;MAP2K2;HLA-E |
| Hepatitis C | PPP2R2B;OAS2;CLDN11;DDX58;PIK3CB;IFNA13;IFNA1;RXRA;CLDN5 |
| Hepatitis B | IFNA7;PIK3R1;CCNA1;AKT1;NFATC2;NFATC3;BAX;HBXIP;TGFBR1 |
| Measles | CD28;IFNA21;IL12A;PRKCQ;AKT1;MAVS;STAT3;PIK3R3;CCND2 |
| Influenza A | HNRNPUL1;Ifna11;HLA-DRB1;ACTB;MAPK9;RSAD2;CASP9;IFNA14;PLG |
| Herpes simplex infection | TNFB;SRSF6;PER2;HLA-DMB;DAXX;SRSF7B;MHC2DAB;SKP1;CCL2 |
Ifnar1 has several biochemical functions, for example, protein binding, type I interferon receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ifnar1 itself. We selected most functions Ifnar1 had, and list some proteins which have the same functions with Ifnar1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZSCAN1;IRF8;MARK4;PPP2R3A;SREK1IP1;GNB1;SF3A1;LYSMD1;ZNF239 |
| type I interferon receptor activity | IFNAR1;IFNAR2 |
Ifnar1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ifnar1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ifnar1.
STAT2; FBXW11; IFNW1; TYK2; IFNAR2; EP300; q86up4_human; glpK
Gene Family
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewAn additional advantage of selecting the IFNAR1 protein is the outstanding technical support offered by its manufacturer.
The combination of the protein's excellence and the manufacturer's exceptional technical support equips me with the necessary resources to overcome experimental obstacles and achieve groundbreaking results.
Their unwavering commitment to customer satisfaction assures me that any challenges or queries I may encounter will be expertly resolved.
Q&As (5)
Ask a questionIn the treatment of autoimmune diseases, IFNAR1 protein can be targeted to modulate the immune response and reduce inflammation.
In research settings, IFNAR1 protein is often studied to better understand its role in immune signaling pathways and disease processes.
IFNAR1 protein is clinically relevant in the treatment of diseases such as viral infections, autoimmune diseases, and certain cancers.
Yes, there are drugs that specifically target IFNAR1 protein, including some that are used in the treatment of multiple sclerosis and certain viral infections.
IFNAR1 protein may be targeted to enhance the body's immune response against cancer cells, leading to potential immunotherapy applications.
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