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Official Full Name Insulin-like Growth Factor 2 Receptor
Background The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
Synonyms cation-independent mannose-6-phosphate receptor; M6PR; CI-MPR; MPR 300; M6P/IGF2R; IGF-II receptor; M6P/IGF2 receptor; OTTHUMP00000017536; CI Man-6-P receptor; 300 kDa mannose 6-phosphate receptor; MPR1; insulin-like growth factor II receptor; cation-independent mannose-6 phosphate receptor; CD222 antigen; MPRI; CD222; CIMPR; M6P-R; IGF2R; insulin-like growth factor 2 receptor
    • Type:
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • E. coli
    • E.coli
    • Human Cell
    • Mammalian Cell
    • NS0
    • Tag :
    • Fc
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IGF2R-290H Recombinant Human IGF2R protein, His-tagged E. coli His
    Human IGF2R-29238TH Recombinant Human IGF2R, His-tagged E.coli His
    Human IGF2R-611H Recombinant Human IGF2R, His-tagged NS0 His
    Human IGF2R-619H Recombinant Human Insulin-Like Growth Factor 2 Receptor E.coli N/A
    Human IGF2R-625H Recombinant Human IGF2R, Fc-tagged, Biotinylated Human Cell Fc
    Human IGF2R-626H Recombinant Human IGF2R, Fc-tagged Human Cell Fc
    Human IGF2R-677H Recombinant Human IGF2R, His-tagged CHO HIS
    Mouse IGF2R-8069M Recombinant Mouse IGF2R Protein Mammalian Cell His
    Mouse Igf2r-849M Recombinant Mouse Igf2r protein, His-tagged E.coli His
    Rat Igf2r-1729R Recombinant Rat Igf2r protein, His & T7-tagged E.coli His/T7
    Chicken IGF2R-6529C Recombinant Chicken IGF2R Mammalian Cell His
    Zebrafish IGF2R-3631Z Recombinant Zebrafish IGF2R Mammalian Cell His

    igf2r involved in several pathways and played different roles in them. We selected most pathways igf2r participated on our site, such as Lysosome, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with igf2r were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis RUFY1; GRK5; ARPC4; HLA-E; PIP5KL1; ADRB3; DNM1B; PDCD6IP; IQSEC3; GIT2B

    igf2r has several biochemical functions, for example, glycoprotein binding, identical protein binding, insulin-like growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by igf2r itself. We selected most functions igf2r had, and list some proteins which have the same functions with igf2r. You can find most of the proteins on our site.

    Function Related Protein
    glycoprotein binding FBXO2; SHB; Serpina1c; B2M; EDEM1; ACE2; FBXO27; RASA1; AZGP1; OS9
    identical protein binding LZTFL1; EPOR; SNX33; DESI1; C1S; SSNA1; FNBP1; RAF1; CUBN; ASMT
    insulin-like growth factor binding IGFBP5B; HTRA3A; HTRA1B; HTRA1; IGFBP2A; CTGFA; IGF1RA; IGFBP2B; IGFALS; IGFBP6B
    insulin-like growth factor-activated receptor activity IGF1R; IGF2R
    mannose binding M6PR; CD209; IGF2R; CD209B; COLEC10; Acr; LMAN1; LMAN2; MANBA; CD209A
    phosphoprotein binding PIH1D1; LRP11; PRKCSH; CSNK1D; TRPV1; PKD2; DPYS; APTX; RB1; PITX2
    protein binding COG8; SHC4; BLOC1S1; ANKRD49; ZFHX3; HADHA; RGS17; BCOR; NAA38; SNAPC5
    receptor activity SLC20A2; PAQR5A; VMN1R40; SEMA4D; THRAP3; NLGN3; EXTL3; CD200R3; TNFRSF6B; GRIN2BB
    transporter activity ABCB11; OCA2; TCOF1; SLC25A13; SLC5A11; ABCA6; SLC2A11L; CPNE1; SYN1; ATP5D

    igf2r has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with igf2r here. Most of them are supplied by our site. Hope this information will be useful for your research of igf2r.

    GGA1; GGA3; IGF2

    O'Doherty, AM; Magee, DA; et al. DNA methylation dynamics at imprinted genes during bovine pre-implantation embryo development. BMC DEVELOPMENTAL BIOLOGY 15:-(2015).
    Moore, GE; Ishida, M; et al. The role and interaction of imprinted genes in human fetal growth. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 370:-(2015).

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