|Official Full Name||Insulin-like Growth Factor 2 Receptor|
|Background||The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.|
|Synonyms||cation-independent mannose-6-phosphate receptor; M6PR; CI-MPR; MPR 300; M6P/IGF2R; IGF-II receptor; M6P/IGF2 receptor; OTTHUMP00000017536; CI Man-6-P receptor; 300 kDa mannose 6-phosphate receptor; MPR1; insulin-like growth factor II receptor; cation-independent mannose-6 phosphate receptor; CD222 antigen; MPRI; CD222; CIMPR; M6P-R; IGF2R; insulin-like growth factor 2 receptor|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
igf2r involved in several pathways and played different roles in them. We selected most pathways igf2r participated on our site, such as Lysosome, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with igf2r were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Lysosome||AGA; ACP2; SLC11A2; GNS; CTSO; IGF2R; CTSSB.1; CD63; AP1S2; ASAH1A|
|Endocytosis||ARRB2; EHD2B; CHMP1B; WASH1; SH3GLB2; VPS45; BF1; SH3GL3B; RAB11FIP1; FGFR3|
igf2r has several biochemical functions, for example, glycoprotein binding, identical protein binding, insulin-like growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by igf2r itself. We selected most functions igf2r had, and list some proteins which have the same functions with igf2r. You can find most of the proteins on our site.
|glycoprotein binding||FGFR1; PTBP3; BBC3; LACRT; LGALS1; TFR2; DNAJC5; BMPR1B; ERBB2; LDLR|
|identical protein binding||GCG; VEGFA; ADIPOR2; SNCA; ACTB; VWA1; CLDN2; ST13; CSNK2B; TK1|
|insulin-like growth factor binding||HTRA1B; IGFBP1B; ESM1; IGFBP7; WISP1; IGF1R; IGFBP1A; IGFALS; HTRA3; IGFBP5A|
|insulin-like growth factor-activated receptor activity||IGF2R; IGF1R|
|mannose binding||MANBA; CD209B; CLEC4M; LMAN2; IGF2R; BSG; CD209A; MRC1; MBL1; LMAN2L|
|phosphoprotein binding||PITX2; TOX3; THRAP3; MS4A2; DPYSL3; PAFAH1B1; YWHAE; TBK1; LYN; SNCA|
|protein binding||CCDC85B; ARID5A; PLEKHB2; KNDC1; SLC38A2; WDR24; NKG7; AQP5; TNIP2; HNRNPA2B1|
|receptor activity||MED30; GFRA1B; MRC1; NLGN2; ITGB1B.1; CD2; APLNR; TNFRSF10A; SLC40A1; CD86|
|transporter activity||SLC26A3; SLC22A23; SLC2A11L; SLC4A8; TMEM184A; KIF20A; AP2M1; CRABP1; SLC23A1; XPO1|
igf2r has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with igf2r here. Most of them are supplied by our site. Hope this information will be useful for your research of igf2r.
GGA1; GGA3; IGF2