IGF2R
-
Official Full Name
Insulin-like Growth Factor 2 Receptor
-
Overview
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. -
Synonyms
cation-independent mannose-6-phosphate receptor; M6PR; CI-MPR; MPR 300; M6P/IGF2R; IGF-II receptor; M6P/IGF2 receptor; OTTHUMP00000017536; CI Man-6-P receptor; 300 kDa mannose 6-phosphate receptor; MPR1; insulin-like growth factor II receptor; cation-independent mannose-6 phosphate receptor; CD222 antigen; MPRI; CD222; CIMPR; M6P-R; IGF2R; insulin-like growth factor 2 receptor;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- CHO
- E. coli
- E.coli
- HEK293
- Human Cell
- Mammalian Cell
- Mammalian cells
- C
- His
- Fc
- GST
- HIS
- His (Fc)
- Avi
- His|T7
- Involved Pathway
- Protein Function
- Interacting Protein
- IGF2R Related Articles
IGF2R involved in several pathways and played different roles in them. We selected most pathways IGF2R participated on our site, such as Lysosome, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF2R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | GLA;CD164;AP4S1;AP1S2;ATP6AP1;ARSB;AGA;SLC11A1;ACP5B |
| Endocytosis | FAM21A;ARFGEF1;RAB11B;KDR;PARD6GA;SH3GLB2B;BF2;TGFB1;ARPC1A |
IGF2R has several biochemical functions, for example, glycoprotein binding, identical protein binding, insulin-like growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF2R itself. We selected most functions IGF2R had, and list some proteins which have the same functions with IGF2R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glycoprotein binding | SERPINA1;ERBB2;STX1A;CDH1;BMPR1A;SDCBP;HSPA5;LCK;OS9 |
| identical protein binding | CBX3;TYROBP;ATXN10;BNIP3;CLDN1;ZNF3;CASP6;DLC;SH3GL2 |
| insulin-like growth factor binding | CTGFA;NOV;IGFBP6A;HTRA3;ESM1;IGFBP5B;Igfbpl1;IGFBP2B;IGF2R |
| insulin-like growth factor-activated receptor activity | IGF1R;IGF2R |
| mannose binding | MBL1;CD209;CLN5;MAN2B1;COLEC10;LMAN2;CD209B;BSG;MANBA |
| phosphoprotein binding | MS4A2;TBL2;PKD2;PIH1D1;IGF2R;PAFAH1B1;SFN;YWHAB;LRP11 |
| protein binding | ZNF187;GEMIN4;CKM;ADCYAP1;GGPS1;KLF2;RTDR1;ATG9A;PCBP1 |
| receptor activity | TNFRSF11B;ITGAX;TNFRSF25;P2RY11;Tnfrsf22;GRIA2B;KLRG1;NR2C2;ITGB3B |
| transporter activity | SLC2A9L1;HIATL1;SLCO3A1;ABCA7;CRABP1;SLCO1D1;SLC12A10.2;SEC22A;ABCB10 |
IGF2R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF2R here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF2R.
GGA1; GGA3; IGF2
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, disruptions in IGF2R function have been associated with insulin resistance and diabetes. Understanding this link is vital for developing interventions in diabetes management.
In some diseases, altered levels of IGF2R may serve as a prognostic marker, providing insights into the progression and severity of the condition.
Yes, several clinical trials are exploring the therapeutic potential of targeting IGF2R in various diseases, including cancer and metabolic disorders.
IGF2R interacts with multiple signaling pathways, including the mTOR pathway, impacting cellular processes such as growth, metabolism, and autophagy.
During fetal development, IGF2R regulates the levels of IGF2, influencing fetal growth. Dysregulation can lead to developmental abnormalities.
Customer Reviews (3)
Write a reviewIts ability to modulate the activity of essential signaling pathways involved in these processes makes it a valuable tool for unraveling their complexities.
the manufacturer's commitment to innovation and product development instills confidence in the reliability and future potential of the ARHGEF9B protein.
Their technical expertise and prompt customer service have been instrumental in resolving any challenges or questions I encountered throughout my research journey.
Ask a Question for All IGF2R Products
Required fields are marked with *
My Review for All IGF2R Products
Required fields are marked with *
