Recombinant Rat Igf2r protein, His & T7-tagged

• Cat.No.: Igf2r-1729R
• Product Overview: Recombinant Rat Igf2r aa. (Val1146~Gln1363 (Accession # G3V824)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Description: Mediates internalization of insulin-like growth factor II; plays a role in lysosomal enzyme transport.
• Source: E. coli
• Species: Rat
• Tag: His & T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 28.4kDa
• Protein length: Val1146~Gln1363 (Accession # G3V824)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 7.9.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: Igf2r insulin-like growth factor 2 receptor [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Igf2r
• Synonyms: Igf2r; insulin-like growth factor 2 receptor; Igfr2; IGF-IIR; cation-independent mannose-6-phosphate receptor
• Gene ID: 25151
• mRNA Refseq: NM_012756.2
• Protein Refseq: NP_036888.2
• UniProt ID: G3V824

Reviews

04/26/2023

Its ability to modulate the activity of essential signaling pathways involved in these processes makes it a valuable tool for unraveling their complexities.

11/16/2021

the manufacturer's commitment to innovation and product development instills confidence in the reliability and future potential of the ARHGEF9B protein.

10/26/2018

Their technical expertise and prompt customer service have been instrumental in resolving any challenges or questions I encountered throughout my research journey.

Q&As

Is there a link between IGF2R and diabetes?

Yes, disruptions in IGF2R function have been associated with insulin resistance and diabetes. Understanding this link is vital for developing interventions in diabetes management.

Can IGF2R be used as a prognostic marker in certain diseases?

In some diseases, altered levels of IGF2R may serve as a prognostic marker, providing insights into the progression and severity of the condition.

Are there ongoing clinical trials targeting IGF2R?

Yes, several clinical trials are exploring the therapeutic potential of targeting IGF2R in various diseases, including cancer and metabolic disorders.

How does IGF2R interact with other signaling pathways in the body?

IGF2R interacts with multiple signaling pathways, including the mTOR pathway, impacting cellular processes such as growth, metabolism, and autophagy.

How does IGF2R contribute to fetal development?

During fetal development, IGF2R regulates the levels of IGF2, influencing fetal growth. Dysregulation can lead to developmental abnormalities.