IL11RA
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Official Full Name
interleukin 11 receptor, alpha
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Background
Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. -
Synonyms
IL11RA; interleukin 11 receptor, alpha; interleukin-11 receptor subunit alpha; hCG_2011440; I11RA_HUMAN; IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA; Interleukin 11 receptor alpha; MGC2146; OTTHUMP00000021300; OTTHUMP00000021301; OTTHUMP00000244525; OTTHUMP00000244527; OTTHUMP00000244532; interleukin-11 receptor alpha chain; CRSDA;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL11RA Related Gene Family
- IL11RA Related Research Area
IL11RA involved in several pathways and played different roles in them. We selected most pathways IL11RA participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL11RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | FAS;XCL1;IL8L2;TNFRSF11B;LEPB;IL1RAP;IL-15RA;PF4;CD27 |
| Jak-STAT signaling pathway | IL20;LIFR;RNF207B;EP300;MYCB;AKT1;SOCS7;RAF1A;IL21R |
| Hematopoietic cell lineage | Flt3l;HLA-DRB1;CD1C;IL6;MME;HLA-DRB3;GP1BA;ITGA1;GYPA |
IL11RA has several biochemical functions, for example, cytokine receptor activity, signal transducer activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL11RA itself. We selected most functions IL11RA had, and list some proteins which have the same functions with IL11RA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine receptor activity | CRFB2;IL31RA;Il6ra;IL4R.1;IL21R.2;CRFB6;IL17RB;Ifnlr1;LEPR |
| signal transducer activity | CHRM5A;GNA15.1;TFG;TAAR12B;CAPN3;TACR3L;TACR3A;EDNRAB;STAT1A |
| transmembrane signaling receptor activity | EBP;EDAR;CLEC2D;FZD8B;NRXN3;LILRA1;ANTXR1;GP1BB;SLC22A17 |
IL11RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL11RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL11RA.
- Q&As
- Reviews
Q&As (10)
Ask a questionPhosphoproteomics and mass spectrometry reveal IL11RA-related signaling pathways.
Flow cytometry and FACS analyze IL11RA expression on different cell types.
X-ray crystallography and cryo-EM reveal the three-dimensional structure of IL11RA.
Gene expression profiling and RNA sequencing unveil IL11RA-associated molecular networks.
Co-immunoprecipitation and pull-down assays confirm IL11RA interactions with IL11 and other partners.
Site-directed mutagenesis identifies IL11RA residues crucial for binding and signaling.
Transgenic mice and knockouts study IL11RA's roles in development and disease.
Experimental strategies characterize IL11RA isoforms and their distinct roles in IL11 signaling.
Isothermal titration calorimetry and surface plasmon resonance measure IL11RA binding properties.
CRISPR-Cas9 knockout and RNA interference reveal IL11RA's functions in specific contexts.
Customer Reviews (3)
Write a reviewHigh affinity binding. -
Stable in solution. -
Effective in hematopoiesis studies. -
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