• Official Full Name

    interleukin 11 receptor, alpha

  • Background

    Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified.
  • Synonyms

    IL11RA; interleukin 11 receptor, alpha; interleukin-11 receptor subunit alpha; hCG_2011440; I11RA_HUMAN; IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA; Interleukin 11 receptor alpha; MGC2146; OTTHUMP00000021300; OTTHUMP00000021301; OTTHUMP00000244525; OTTHUMP00000244527; OTTHUMP00000244532; interleukin-11 receptor alpha chain; CRSDA;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Species :
    • Canine
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Tag :
    • Fc
    • Avi
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Canine IL11RA-1046C Recombinant Canine IL11RA Protein, Fc-tagged HEK293 Fc
    Canine IL11RA-001CCL Recombinant Canine IL11RA cell lysate Human Cell N/A
    Canine IL11RA-173C Recombinant Canine IL11RA, His-tagged Human Cell His
    Canine IL11RA-174C Recombinant Canine IL11RA, LEVLFQ tagged Human Cell His
    Chicken IL11RA-3466C Recombinant Chicken IL11RA Mammalian Cell His
    Human IL11RA-2389HCL Recombinant Human IL11RA cell lysate Human Cell N/A
    Human IL11RA-561H Recombinant Human IL11RA Protien, GST-tagged E. coli GST
    Human IL11RA-1328H Recombinant Human IL11RA protein, His-tagged E.coli His
    Human IL11RA-0195H Recombinant Human IL11RA protein, His-tagged HEK293 His
    Human IL11RA-3155H Recombinant Human IL11RA protein, His-tagged HEK293 His
    Human IL11RA-0196H Recombinant Human IL11RA protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi
    Human IL11RA-0197H Recombinant Human IL11RA protein, Fc-tagged HEK293 Fc
    Mouse IL11RA-2558MCL Recombinant Mouse IL11RA cell lysate Human Cell N/A
    Zebrafish IL11RA-6298Z Recombinant Zebrafish IL11RA Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL11RA Related Gene Family
    • IL11RA Related Research Area

    IL11RA involved in several pathways and played different roles in them. We selected most pathways IL11RA participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL11RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionFAS;XCL1;IL8L2;TNFRSF11B;LEPB;IL1RAP;IL-15RA;PF4;CD27
    Jak-STAT signaling pathwayIL20;LIFR;RNF207B;EP300;MYCB;AKT1;SOCS7;RAF1A;IL21R
    Hematopoietic cell lineageFlt3l;HLA-DRB1;CD1C;IL6;MME;HLA-DRB3;GP1BA;ITGA1;GYPA

    IL11RA has several biochemical functions, for example, cytokine receptor activity, signal transducer activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL11RA itself. We selected most functions IL11RA had, and list some proteins which have the same functions with IL11RA. You can find most of the proteins on our site.

    Function Related Protein
    cytokine receptor activityCRFB2;IL31RA;Il6ra;IL4R.1;IL21R.2;CRFB6;IL17RB;Ifnlr1;LEPR
    signal transducer activityCHRM5A;GNA15.1;TFG;TAAR12B;CAPN3;TACR3L;TACR3A;EDNRAB;STAT1A
    transmembrane signaling receptor activityEBP;EDAR;CLEC2D;FZD8B;NRXN3;LILRA1;ANTXR1;GP1BB;SLC22A17

    IL11RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL11RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL11RA.

    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    Can you explain how phosphoproteomics and mass spectrometry shed light on IL11RA-mediated signaling cascades and post-translational modifications? 04/16/2022

    Phosphoproteomics and mass spectrometry reveal IL11RA-related signaling pathways.

    How are flow cytometry and fluorescence-activated cell sorting (FACS) employed to analyze IL11RA expression on different cell populations? 07/13/2021

    Flow cytometry and FACS analyze IL11RA expression on different cell types.

    Could you elaborate on how X-ray crystallography and cryo-electron microscopy contribute to understanding the three-dimensional structure of IL11RA? 06/12/2020

    X-ray crystallography and cryo-EM reveal the three-dimensional structure of IL11RA.

    What insights have gene expression profiling and RNA sequencing provided regarding IL11RA-related molecular pathways and networks? 09/10/2019

    Gene expression profiling and RNA sequencing unveil IL11RA-associated molecular networks.

    How do techniques like co-immunoprecipitation and pull-down assays validate IL11RA's interactions with IL11 and other signaling partners? 08/29/2019

    Co-immunoprecipitation and pull-down assays confirm IL11RA interactions with IL11 and other partners.

    What role does site-directed mutagenesis play in identifying IL11RA residues critical for IL11 binding and downstream signaling activation? 07/28/2019

    Site-directed mutagenesis identifies IL11RA residues crucial for binding and signaling.

    How are animal models like transgenic mice and tissue-specific knockouts utilized to study the in vivo roles of IL11RA in development and disease? 05/18/2019

    Transgenic mice and knockouts study IL11RA's roles in development and disease.

    Can you explain the experimental strategies used to characterize IL11RA isoforms and their differential roles in IL11 signaling? 04/08/2018

    Experimental strategies characterize IL11RA isoforms and their distinct roles in IL11 signaling.

    How are biophysical techniques such as isothermal titration calorimetry and surface plasmon resonance used to determine IL11RA's binding affinities and kinetics? 03/08/2018

    Isothermal titration calorimetry and surface plasmon resonance measure IL11RA binding properties.

    What methods like CRISPR-Cas9 knockout and RNA interference help elucidate the functional significance of IL11RA in specific biological contexts? 10/18/2017

    CRISPR-Cas9 knockout and RNA interference reveal IL11RA's functions in specific contexts.

    Customer Reviews (3)

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      High affinity binding. -


        Stable in solution. -


          Effective in hematopoiesis studies. -

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