Il2rg
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Official Full Name
interleukin 2 receptor, gamma chain -
Overview
CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, also known as common gamma chain (gammac), or IL-2 receptor gamma subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an ess -
Synonyms
IL2RG;interleukin 2 receptor, gamma chain;cytokine receptor common subunit gamma;p64;IL-2RG;gammaC;gamma C receptor;common gamma chain;IL-2R subunit gamma;IL-2 receptor subunit gamma;common cytokine receptor gamma chain;interleukin-2 receptor subunit gamma;gc;[g]c;CD132;gamma(c)
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Rat
- Cynomolgus
- Leu23-Asn254
- Pig
- Dog
- Mus musculus
- E.coli
- HEK293
- Sf21 Cells
- Mammalian Cells
- Insect Cells
- Human Cells
- C-hFc
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Fc
- Non
- hIgG4
- Avi
Involved Pathway
Il2rg involved in several pathways and played different roles in them. We selected most pathways Il2rg participated on our site, such as Cytokine-cytokine receptor interaction,Endocytosis,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il2rg were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCR6,NGFRB,TNFRSF18,Ccl21c,IL23,TNFSF18,CCL15,IL15,CCR1,IL12BA |
| Endocytosis | FGFR4,RAB5C,DNM2A,VPS37B,RAB11FIP2,DDL-2,ARFGEF1,LDLR,CAPZA1A,VTA1 |
| Primary i | CD8A,PTPRC,BLNK,IL7R,AICDA,DCLRE1C,CD19,CD8B1,TAP1,RAG2 |
| nodeficiency | RFX5,ORAI1,CD8A,RAG1,TNFRSF13B,IGLL1,BTK,ICOS,CD79A,CD3D |
| Inflammatory bowel disease (IBD) | TLR5,IL6,MAF,IL1B,IL4R,Il2,STAT6,TNF,HLA-DMB,IFNG |
| PIK-Akt signaling pathway | LAMA2,TSC1,RAF1,IL6R,LPAR2,PDGFD,FGF3,IL4R,Gh,FGF9 |
| Jak-STAT signaling pathway | CRFB2,CSH2,IL12BA,IL11RA,AKT1,IL7R,IFNGR2,TP-1,STAT1,IL13RA1 |
| Measles | STAT3,cgr2b,NFKBIB,PIK3CD,STAT1,CLEC4M,GSK3B,Fasl,IKBKE,IFNA17 |
| HTLV-I infection | PRKACB,WNT5A,H2-AA,ITGB2L,ANAPC11,APC,HLA-C,NFKB2,WNT8B,FZD8 |
Protein Function
Il2rg has several biochemical functions, for example, interleukin-2 binding,contributes_to interleukin-2 receptor activity,contributes_to interleukin-4 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Il2rg itself. We selected most functions Il2rg had, and list some proteins which have the same functions with Il2rg. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LSM4,WSB1,C14orf166,SEMG2,FAM65B,CCNB2,RBM3,CACFD1,ZNF821,FAM21C |
| interleukin-2 binding | IL2RA,IL2RB |
| contributes_to interleukin-2 receptor activity | IL2RB |
Interacting Protein
Il2rg has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il2rg here. Most of them are supplied by our site. Hope this information will be useful for your research of Il2rg.
IL4;IL4R;NOTCH2NL;IL15RA;IL7;IL7R;GRB2
Il2rg Related Signal Pathway
Resources
Research Area
Natural Killer Cells (NK Cells) MarkersNatural Killer T (NKT) Cells
T Cell Cytokine Signaling
CD Antigen (Helper T Cells)
Cytokines and Chemokines in B Cell Development
Common gamma Chain Family Receptors
Related Services
Related Products
References
- Motobayashi, M; Inaba, Y; et al. Successful treatment for West syndrome with severe combined immunodeficiency. BRAIN & DEVELOPMENT 37:140-144(2015).
- Wan, SS; Zhao, ED; et al. Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells. GASTROENTEROLOGY 147:1393-1404(2014).
