Il2rg
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Official Full Name
interleukin 2 receptor, gamma chain
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Background
CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, also known as common gamma chain (gammac), or IL-2 receptor gamma subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an ess -
Synonyms
IL2RG; interleukin 2 receptor, gamma chain; cytokine receptor common subunit gamma; p64; IL-2RG; gammaC; gamma C receptor; common gamma chain; IL-2R subunit gamma; IL-2 receptor subunit gamma; common cytokine receptor gamma chain; interleukin-2 receptor subunit gamma; gc; [g]c; CD132; gamma(c);
- Involved Pathway
- Protein Function
- Interacting Protein
- Il2rg Related Articles
- Il2rg Related Gene Family
- Il2rg Related Research Area
- Il2rg Related Signal Pathway
Il2rg involved in several pathways and played different roles in them. We selected most pathways Il2rg participated on our site, such as Cytokine-cytokine receptor interaction, Endocytosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il2rg were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IFNA4;EDA2R;IL8L2;GHR;CCL17;RELT;KITB;CXCL8;TNFRSF8 |
| Endocytosis | LDLRAP1A;PIP5K1AB;ACAP3;CCR5;EPN3;PDCD6IP;BC2;IQSEC1;ARPC4 |
| PIK-Akt signaling pathway | KLK1B4;IRS1;PPP2R2B;FGF6;GYS1;TNC;CCND3;NGFR;GYS2 |
| Jak-STAT signaling pathway | IFNA7;RAF1A;MPL;PIAS4B;IL4R;IRX1;PIAS1;IFNK;IL21R.1 |
| Measles | IFNA6;IL1A;CD209C;EIF2AK1;MAP3K7;TRP53;IL12A;HSPA8;HSPA1A |
| HTLV-I infection | TLN1;TNFRSF1A;CCND1;ELK1;VCAM1;HRAS;PIK3R1;FZD6;NRAS |
| Inflammatory bowel disease (IBD) | IL18;Il4ra;IL12A;RORA;TGFB1;HLA-DRB5;IFNGR2;IL2RG;HLA-DOB |
| Primary i | RFX5;CD40;TAP1;UNG;TNFRSF13B;Cd79a, Cd79b;AICDA;RAG1;TAP2 |
| nodeficiency | ICOS;RFX5;DCLRE1C;ZAP70;CD8B;IL2RG;IL7R;BTK;PTPRC |
Il2rg has several biochemical functions, for example, interleukin-2 binding, contributes_to interleukin-2 receptor activity, contributes_to interleukin-4 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Il2rg itself. We selected most functions Il2rg had, and list some proteins which have the same functions with Il2rg. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-2 binding | IL2RG;IL2RB;IL2RA |
| contributes_to interleukin-2 receptor activity | IL2RB;IL2RG |
| contributes_to interleukin-4 receptor activity | |
| interleukin-7 binding | |
| contributes_to interleukin-7 receptor activity | |
| protein binding | ARL4A;RAP1A;DHX30;FTSJ3;HSPB1;LSM6;MBIP;FAT4;FOSL1 |
Il2rg has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il2rg here. Most of them are supplied by our site. Hope this information will be useful for your research of Il2rg.
IL4; IL4R; NOTCH2NL; IL15RA; IL7; IL7R; GRB2
- Q&As
- Reviews
Q&As (6)
Ask a questionThe use of IL2RG may cause chest tightness, skin itching, allergies and other side effects, you need to contact the doctor for timely treatment.
The dosage and use method of IL2RG need to be determined according to the condition and individual situation, and need to be prescribed by a clinician.
Enhances the immunity of the human immune system by increasing the number and improving the function of immune cells in the body.
IL2RG is mainly used in the treatment of immune deficiency diseases, such as systemic eosinophilic granulomatosis, X-linked immunodeficiency disease, etc.
In view of possible risks, the use of IL2RG should be strictly in accordance with the doctor's advice, and avoid changing the dosage and frequency of medication.
IL2RG pharmacological features are contained in vivo to enhance the immunity of the human immune system by increasing the number of immune cells and improving their function.
Customer Reviews (3)
Write a reviewPurity of IL2RG is tested to ensure that no impurities are present in the protein, and its binding capacity and signal transduction function to the corresponding ligand, such as IL-2, is verified by appropriate bioactivity experiments. -
Solubility and stability of IL2RG under different solution conditions were investigated to ensure its stability during storage and use and its ability to maintain its biological activity. -
To evaluate the stability of the three-dimensional structure of IL2RG, the structure of the protein and its changes can be studied by crystallography and nuclear magnetic resonance techniques. -
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