Recombinant Human IL2RG, Gamma, Fc Chimera IL2RG-119H

Recombinant Human IL2RG, Gamma, Fc Chimera

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Cat.No. : IL2RG-119H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human interleukin 2 receptor, gamma (severe combined immunodeficiency) protein was expressed in modifiedhuman 293 cellsencoding the signal peptide and extracellular domain of human Interleukin 2 receptor gamma chain (aa 1-259). Itwas fused to the Fc region of human IgG1 (aa 93-330).
Description : Interleukin-2 (IL-2) is a pleiotropic glycoprotein that mediates the production of regulatory T cells and promotes T cell dependent tolerance. Mutations in the gene encoding IL-2R gamma results in X-linked severe combined immunodeficiency, which is characterised by an absence of T and NK cells, and near normal numbers of functionally deficient B cells.
Source : Human 293 cells.
Amino Acid Sequence : LNTTILTPN GNEDTTADFFLTT MPTDSL SVSTLPLP EVQCFVFNV EYMNCTWN SSSEPQPTN L T L H YWYK NSDNDK VQKCSH YLFSEEI TSGCQL QKKEIHL YQTFVV QLQDPR EP R RQ ATQ MLKL QNLVIPW APENLTL HKLSESQ LELNWN NRFLNHC LEHLVQY R TDWDHS WTEQS VDYRHK FSLPSV DGQKRY TFRVRS RFNPLC GSAQHW S EWSHP IHWGS NTSKE NPFLFA WIPKVD KKVEP KSCDK THTCPP CPAPE L LGGPS VFLFPP KPKDTL MISRTP EVTCVV VDVSHE DPEVKF NWYVDG VEVHN AKTKPR EEQYN STYRVV SVLTVL HQDWL NGKEY KCKVS NKALPAPIE KTISKA KGQP REPQVYT LPPSRDELTKN QVSLTCLVKGFY P SDIAVEWESN GQ PENNYKTTP PVLDSDG SFFLYSKL TVDKSRW QQGNVFS CSVMHEAL HNHY TQ K S LSLSPGK.
Molecular Mass : IL-2R gamma-Fc Chimera migrates as a band between 75 and 105 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation. This compares with the unmodified IL-2R gamma-Fc that has a predicted molecular mass of 55.1 kDa.
PI : IL-2R gamma-Fc Chimera separates into a number of isoforms with a pI between 4.9 and 7.2 in 2D PAGE due to post-translational modifications, in particular glycosylation. This compares with the unmodified IL-2 R gamma-Fc that has a predicted pI of 6.68.
% Carbohydrate : Purified IL-2R gamma-Fc Chimera consists of 25-50% carbohydrate by weight.
Glycosylation : IL-2R gamma-Fc Chimera has N-linked and O-linked oligosaccharides.
Purity : >95%, as determined by SDS-PAGE and visualized by silver stain.
Formulation : When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
Reconstitution : It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Storage : Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
PDB rendering based on 2b5i. :

Gene Name : IL2RG interleukin 2 receptor, gamma (severe combined immunodeficiency) [ Homo sapiens ]
Synonyms : IL2RG; interleukin 2 receptor, gamma (severe combined immunodeficiency); CD132; IMD4; SCIDX; SCIDX1; common cytokine receptor gamma chain; interleukin 2 receptor gamma chain; interleukin 2 receptor, gamma; p64; interleukin 2 receptor, gamma; Interleukin-2 receptor gamma chain; IL-2R gamma chain; CD132 antigen
Gene ID : 3561
mRNA Refseq : NM_000206
Protein Refseq : NP_000197
MIM : 308380
UniProt ID : P31785
Chromosome Location : Xq13.1
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Endocytosis; Primary immunodeficiency e
Function : interleukin-2 receptor activity; protein binding; receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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