Recombinant Human IL2RG, Gamma, Fc Chimera
| Cat.No. : | IL2RG-119H |
| Product Overview : | Recombinant Human interleukin 2 receptor, gamma (severe combined immunodeficiency) protein was expressed in modifiedhuman 293 cellsencoding the signal peptide and extracellular domain of human Interleukin 2 receptor gamma chain (aa 1-259). Itwas fused to the Fc region of human IgG1 (aa 93-330). |
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- Gene Information
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| Cat. No. : | IL2RG-119H |
| Description : | Interleukin-2 (IL-2) is a pleiotropic glycoprotein that mediates the production of regulatory T cells and promotes T cell dependent tolerance. Mutations in the gene encoding IL-2R gamma results in X-linked severe combined immunodeficiency, which is characterised by an absence of T and NK cells, and near normal numbers of functionally deficient B cells. |
| Source : | Human 293 cells. |
| Amino Acid Sequence : | LNTTILTPN GNEDTTADFFLTT MPTDSL SVSTLPLP EVQCFVFNV EYMNCTWN SSSEPQPTN L T L H YWYK NSDNDK VQKCSH YLFSEEI TSGCQL QKKEIHL YQTFVV QLQDPR EP R RQ ATQ MLKL QNLVIPW APENLTL HKLSESQ LELNWN NRFLNHC LEHLVQY R TDWDHS WTEQS VDYRHK FSLPSV DGQKRY TFRVRS RFNPLC GSAQHW S EWSHP IHWGS NTSKE NPFLFA WIPKVD KKVEP KSCDK THTCPP CPAPE L LGGPS VFLFPP KPKDTL MISRTP EVTCVV VDVSHE DPEVKF NWYVDG VEVHN AKTKPR EEQYN STYRVV SVLTVL HQDWL NGKEY KCKVS NKALPAPIE KTISKA KGQP REPQVYT LPPSRDELTKN QVSLTCLVKGFY P SDIAVEWESN GQ PENNYKTTP PVLDSDG SFFLYSKL TVDKSRW QQGNVFS CSVMHEAL HNHY TQ K S LSLSPGK. |
| Molecular Mass : | IL-2R gamma-Fc Chimera migrates as a band between 75 and 105 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation. This compares with the unmodified IL-2R gamma-Fc that has a predicted molecular mass of 55.1 kDa. |
| PI : | IL-2R gamma-Fc Chimera separates into a number of isoforms with a pI between 4.9 and 7.2 in 2D PAGE due to post-translational modifications, in particular glycosylation. This compares with the unmodified IL-2 R gamma-Fc that has a predicted pI of 6.68. |
| % Carbohydrate : | Purified IL-2R gamma-Fc Chimera consists of 25-50% carbohydrate by weight. |
| Glycosylation : | IL-2R gamma-Fc Chimera has N-linked and O-linked oligosaccharides. |
| Purity : | >95%, as determined by SDS-PAGE and visualized by silver stain. |
| Formulation : | When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose. |
| Reconstitution : | It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. |
| Storage : | Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended. |
| Gene Name : | IL2RG interleukin 2 receptor, gamma (severe combined immunodeficiency) [ Homo sapiens ] |
| Synonyms : | IL2RG; interleukin 2 receptor, gamma (severe combined immunodeficiency); CD132; IMD4; SCIDX; SCIDX1; common cytokine receptor gamma chain; interleukin 2 receptor gamma chain; interleukin 2 receptor, gamma; p64; interleukin 2 receptor, gamma; Interleukin-2 receptor gamma chain; IL-2R gamma chain; CD132 antigen |
| Gene ID : | 3561 |
| mRNA Refseq : | NM_000206 |
| Protein Refseq : | NP_000197 |
| MIM : | 308380 |
| UniProt ID : | P31785 |
| Chromosome Location : | Xq13.1 |
| Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Endocytosis; Primary immunodeficiency e |
| Function : | interleukin-2 receptor activity; protein binding; receptor activity |
Products Types
| ◆ Recombinant Protein | ||
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| IL2RG-2070R | Recombinant Rhesus Macaque IL2RG Protein, His (Fc)-Avi-tagged | +Inquiry |
| IL2RG-067H | Recombinant Human IL2RG Protein, C-His-tagged | +Inquiry |
| IL2RG-5194H | Recombinant Human IL2RG Protein | +Inquiry |
| IL2RG-14197H | Recombinant Human IL2RG Protein, GST-tagged | +Inquiry |
| ◆ Lysates | ||
| IL2RG-502HCL | Recombinant Human IL2RG cell lysate | +Inquiry |
| IL2RG-1476RCL | Recombinant Rat IL2RG cell lysate | +Inquiry |
| IL2RG-1481HCL | Recombinant Human IL2RG cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe use of IL2RG may cause chest tightness, skin itching, allergies and other side effects, you need to contact the doctor for timely treatment.
The dosage and use method of IL2RG need to be determined according to the condition and individual situation, and need to be prescribed by a clinician.
Enhances the immunity of the human immune system by increasing the number and improving the function of immune cells in the body.
IL2RG is mainly used in the treatment of immune deficiency diseases, such as systemic eosinophilic granulomatosis, X-linked immunodeficiency disease, etc.
In view of possible risks, the use of IL2RG should be strictly in accordance with the doctor's advice, and avoid changing the dosage and frequency of medication.
IL2RG pharmacological features are contained in vivo to enhance the immunity of the human immune system by increasing the number of immune cells and improving their function.
Customer Reviews (3)
Write a reviewPurity of IL2RG is tested to ensure that no impurities are present in the protein, and its binding capacity and signal transduction function to the corresponding ligand, such as IL-2, is verified by appropriate bioactivity experiments. -
Solubility and stability of IL2RG under different solution conditions were investigated to ensure its stability during storage and use and its ability to maintain its biological activity. -
To evaluate the stability of the three-dimensional structure of IL2RG, the structure of the protein and its changes can be studied by crystallography and nuclear magnetic resonance techniques. -
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