Recombinant Cynomolgus IL2RG protein, His-tagged

• Cat.No.: IL2RG-382C
• Product Overview: Cynomolgus CD132/IL2RG Protein is expressed from mammalian with His Tag at the C-terminal. It contains Leu23-Asn254.

Specification

• Description: The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL2 with any appreciable affinity, it is required for IL-2 receptor signaling.
• Source: HEK293
• Species: Cynomolgus
• Tag: His
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 28.2KDa. Due to glycosylation, the protein migrates to 50- 68KDa based on Bis-Tris PAGE result.
• Protein length: Leu23-Asn254
• Endotoxin: Less than 0.1EU per ug by the LAL method.
• Purity: > 95% as determined by SDS-PAGE
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: IL2RG interleukin 2 receptor subunit gamma [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: IL2RG
• Synonyms: CD132 antigen; CD132; CIDX; combined immunodeficiency, X-linked; common cytokine receptor gamma chain; Common gamma Chain; common gamma-chain; cytokine receptor common subunit gamma; gamma(c); IL-2 R gamma; IL-2 receptor subunit gamma; IL2R gamma; IL-2R subunit gamma; IL2RG; IL-2RG; IMD4; interleukin 2 receptor, gamma; Interleukin-2 receptor subunit gamma; P64; SCIDX; SCIDX1; severe combined immunodeficiency.
• Gene ID: 641338
• mRNA Refseq: NM_001035529.1
• Protein Refseq: NP_001030606.1
• UniProt ID: Q38JL2

Reviews

10/13/2022

Solubility is very good and can be easily dissolved in various buffers.

05/13/2022

Quality I use is very good and I have recommended this product to my colleagues and friends.

05/16/2021

The anti-pollution ability is very strong, not easy to be polluted.

Q&As

Are there any side effects of using this protein?

The use of IL2RG may cause chest tightness, skin itching, allergies and other side effects, you need to contact the doctor for timely treatment.

What is the dosage and use method of IL2RG?

The dosage and use method of IL2RG need to be determined according to the condition and individual situation, and need to be prescribed by a clinician.

Does IL2RG have a role and what is the mechanism?

Enhances the immunity of the human immune system by increasing the number and improving the function of immune cells in the body.

Which diseases is IL2RG used to treat?

IL2RG is mainly used in the treatment of immune deficiency diseases, such as systemic eosinophilic granulomatosis, X-linked immunodeficiency disease, etc.

What measures can be taken to mitigate the possible risks of IL2RG?

In view of possible risks, the use of IL2RG should be strictly in accordance with the doctor's advice, and avoid changing the dosage and frequency of medication.

What are the pharmacological characteristics of IL2RG?

IL2RG pharmacological features are contained in vivo to enhance the immunity of the human immune system by increasing the number of immune cells and improving their function.