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Recombinant Human IL2RG protein, Fc-tagged
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Cat.No. : | IL2RG-7289H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human IL2RG (Leu23-Asn254) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293). |
Description : | IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID). |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Predicted N Terminal : | Leu23 |
Form : | Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 53.5 kDa. The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Leu23-Asn254 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >98% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
SDS-PAGE of IL2RG-7289H : |
![]() Human IL-2 R gamma, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 98%. |
Gene Name : | IL2RG |
Official Symbol : | IL2RG |
Synonyms : | IL2RG; interleukin 2 receptor, gamma; CIDX, combined immunodeficiency, X linked, IMD4, SCIDX1, severe combined immunodeficiency; cytokine receptor common subunit gamma; CD132; gammaC; gamma(c); CD132 antigen; common gamma-chain; IL-2R subunit gamma; IL-2 receptor subunit gamma; severe combined immunodeficiency; combined immunodeficiency, X-linked; common cytokine receptor gamma chain; interleukin-2 receptor subunit gamma; P64; CIDX; IMD4; SCIDX; IL-2RG; SCIDX1 |
Gene ID : | 3561 |
mRNA Refseq : | NM_000206 |
Protein Refseq : | NP_000197 |
MIM : | 308380 |
UniProt ID : | P31785 |
◆ Recombinant Protein
IL2RG-5194H | Recombinant Human IL2RG Protein | +Inquiry |
IL2RG-5193H | Recombinant Human IL2RG Protein, GST-tagged | +Inquiry |
IL2RG-14197H | Recombinant Human IL2RG, GST-tagged | +Inquiry |
IL2RG-6096C | Recombinant Chicken IL2RG | +Inquiry |
IL2RG-151H | Recombinant Human IL2RG Protein, His-tagged | +Inquiry |
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◆ Lysates
IL2RG-1476RCL | Recombinant Rat IL2RG cell lysate | +Inquiry |
IL2RG-2908MCL | Recombinant Mouse IL2RG cell lysate | +Inquiry |
IL2RG-1481HCL | Recombinant Human IL2RG cell lysate | +Inquiry |
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