Recombinant Human IL2RG Protein, C-His-tagged

Cat.No. : IL2RG-067H
Product Overview : Recombinant Human IL2RG Protein with C-His tag was expressed in E. coli.
  • Specification
  • Gene Information
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Description : The IL-2 receptor is a multicomponent complex consisting of three subunits, a, b and g, each of which is required for high affinity binding of IL-2. The a chain functions primarily in binding IL-2, whereas the b and g chains contribute to IL-2 binding and are essential to IL-2-induced activation of signaling pathways leading to T cell growth. Both IL-4R and IL-7R were initially described as single chain high affinity ligand binding cytokine receptors. However, it is now well established that the IL-2R g chain functions as a second subunit of the high affinity IL-4R and IL-7R receptors. Consequently, the originally described subunits of these latter receptors are now referred to as IL-4Ra and IL-7Ra respectively, while the common subunit is referred to as gc. Although the common g chain enhances ligand binding in these three cytokine receptors, it has no capacity to bind these ligands on its own.There is evidence that the gc chain is also a subunit of IL-13R.
Source : E. coli
Species : Human
Tag : C-His
Molecular Mass : ~26 kDa
AA Sequence : LNTTILTPNGNEDTTADFFLTTMPT DSLSVSTLPLPEVQCFVFNVEYMNC TWNSSSEPQPTNLTLHYWYKNSDND KVQKCSHYLFSEEITSGCQLQKKEI HLYQTFVVQLQDPREPRRQATQMLK LQNLVIPWAPENLTLHKLSESQLEL NWNNRFLNHCLEHLVQYRTDWDHSW TEQSVDYRHKFSLPSVDGQKRYTFR VRSRFNPLCGSAQHWSEWSHPIHWG SNTSKENPFLFALEA
Purity : Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
Notes : For research use only, not for use in diagnostic procedure.
Storage : Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
Concentration : ≥0.5 mg/mL
Storage Buffer : PBS, 4M Urea, pH7.4
Gene Name : IL2RG interleukin 2 receptor, gamma [ Homo sapiens (human) ]
Official Symbol : IL2RG
Synonyms : IL2RG; interleukin 2 receptor, gamma; CIDX, combined immunodeficiency, X linked , IMD4, SCIDX1, severe combined immunodeficiency; cytokine receptor common subunit gamma; CD132; gammaC; gamma(c); CD132 antigen; common gamma-chain; IL-2R subunit gamma; IL-2 receptor subunit gamma; severe combined immunodeficiency; combined immunodeficiency, X-linked; common cytokine receptor gamma chain; interleukin-2 receptor subunit gamma; P64; CIDX; IMD4; SCIDX; IL-2RG; SCIDX1;
Gene ID : 3561
mRNA Refseq : NM_000206
Protein Refseq : NP_000197
MIM : 308380
UniProt ID : P31785

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there any side effects of using this protein? 12/23/2022

The use of IL2RG may cause chest tightness, skin itching, allergies and other side effects, you need to contact the doctor for timely treatment.

What is the dosage and use method of IL2RG? 11/03/2022

The dosage and use method of IL2RG need to be determined according to the condition and individual situation, and need to be prescribed by a clinician.

Does IL2RG have a role and what is the mechanism? 11/28/2021

Enhances the immunity of the human immune system by increasing the number and improving the function of immune cells in the body.

Which diseases is IL2RG used to treat? 06/22/2021

IL2RG is mainly used in the treatment of immune deficiency diseases, such as systemic eosinophilic granulomatosis, X-linked immunodeficiency disease, etc.

What measures can be taken to mitigate the possible risks of IL2RG? 06/15/2021

In view of possible risks, the use of IL2RG should be strictly in accordance with the doctor's advice, and avoid changing the dosage and frequency of medication.

What are the pharmacological characteristics of IL2RG? 08/14/2019

IL2RG pharmacological features are contained in vivo to enhance the immunity of the human immune system by increasing the number of immune cells and improving their function.

Customer Reviews (3)

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Reviews
10/13/2022

    Solubility is very good and can be easily dissolved in various buffers.

    05/13/2022

      Quality I use is very good and I have recommended this product to my colleagues and friends.

      05/16/2021

        The anti-pollution ability is very strong, not easy to be polluted.

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