Recombinant Human IL2RG, Fc-tagged

• Cat.No.: IL2RG-29663TH
• Product Overview: Recombinant fragment, corresponding to amino acids 23-259 of Human IL2 Receptor gamma fused to the Fc region of human IgG1 expressed in modified human 293 cells.

Specification

• Description: The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
• Conjugation: Fc
• Form: Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not reco
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin
• Storage: Store at +4°C.
• Sequences of amino acids: Theoretical Sequence:LNTTILTPNGNEDTTADFFLTTMPT DSLS VSTLPLPEVQCFVFNVEYMNCTWNS SSEPQPTNLTLHY WYKNSDNDKVQKCSHYLFSEEITSG CQLQKKEIHLYQT FVVQLQDPREPRRQATQMLKLQNLV IPWAPENLTLHKLSESQLELNWNNR FLNHCLEHLVQYRTDWDHSWTEQSV DYR HKFSLPSVDGQKRYTFRVRSRFNPL CGSAQHWSEWSHP IHWGSNTSKENPFLFAWIPKVDKKV EPKSCDKTHTCPP CPAPELLGGPSVFLFPPKPKDTLMI SRTPEVTCVVVDV SHEDPEVKFNWYVDGVEVHNAKTKP REEQYNSTYRVVSVLTVLHQDWLNG KEYKCKVSNKALPAPIEKTISKAKG QPR EPQVYTLPPSRDELTKNQVSLTCLV KGFYPSDIAVEWE SNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQG NVFSCSVMHEALHNHYTQKSLSLSP GK

Gene Information

• Gene Name: IL2RG interleukin 2 receptor, gamma [ Homo sapiens ]
• Official Symbol: IL2RG
• Synonyms: IL2RG; interleukin 2 receptor, gamma; CIDX, combined immunodeficiency, X linked , IMD4, SCIDX1, severe combined immunodeficiency; cytokine receptor common subunit gamma; CD132
• Gene ID: 3561
• mRNA Refseq: NM_000206
• Protein Refseq: NP_000197
• MIM: 308380
• Uniprot ID: P31785
• Chromosome Location: Xq13
• Pathway: Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; Endocytosis, organism-specific biosystem
• Function: cytokine receptor activity; interleukin-2 binding; contributes_to interleukin-2 receptor activity; contributes_to interleukin-4 receptor activity; contributes_to interleukin-7 receptor activity