ILK
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Official Full Name
integrin-linked kinase
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Overview
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. -
Synonyms
ILK; integrin-linked kinase; integrin-linked protein kinase; ILK-1; p59ILK; integrin-linked kinase-2; 59 kDa serine/threonine-protein kinase; P59; ILK-2; DKFZp686F1765;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ILK Related Articles
- ILK Related Research Area
ILK involved in several pathways and played different roles in them. We selected most pathways ILK participated on our site, such as PPAR signaling pathway, Focal adhesion, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ILK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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PPAR signaling pathway | SCDB;SCD;SLC27A2;CYP4A14;ACOX2;UBC;DBI;FABP3;FADS2 |
Focal adhesion | VASPA;HRAS;CAV3;MYLPFB;Itga10&Itgb1;PARVG;PDGFRA;CAV2;VEGFAA |
Bacterial invasion of epithelial cells | HCLS1;CDC42;ARPC1B;ARPC3;CTTN;BCAR1;RAC1;WAS;PIK3CB |
Endometrial cancer | AXIN2;PIK3CB;CASP9;NRAS;TP53;PIK3CA;TCF7;FOXO3;ARAF |
ILK has several biochemical functions, for example, ATP binding, SH3 domain binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ILK itself. We selected most functions ILK had, and list some proteins which have the same functions with ILK. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | MAP3K10;MSH3;PRPS1L1;EPHA4B;KCNJ10;MYH13;CDC34B;DDX59;MAGI1 |
SH3 domain binding | SH3BP5B;OSTF1;SH3BGR;CD2AP;BCAR1;DNM2;EVL;INPP5J;CYBA |
integrin binding | ACTN1;ACTN3;COL4A3;ICAM4;Tcam1;FCER2;EMP2;TIMP2;WISP1B |
protein binding | MRPL27;ATG101;FLII;APOBEC1;PCGF5;HHLA3;DCAF12L1;TMEM8B;SAMM50 |
protein kinase binding | THY1;TELO2;GSTP2;CAMK2N1A;LLGL1;PRKAB1;MEF2A;CAV1;TPRKB |
protein serine/threonine kinase activity | STK24;SLK;DYRK3;NEK10;CSNK2A1;MAPK4;IRAK2;ACVRL1;MAPK8B |
signal transducer activity | GPR89;ADRB2A;OLFR495;GPR132;TMTOPSA;VIPR1B;C18orf32;STAT6;CTNNB1 |
ILK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ILK here. Most of them are supplied by our site. Hope this information will be useful for your research of ILK.
PARVA; LIMS1
- Q&As
- Reviews
Q&As (6)
Ask a questionILK may play an important role, in a variety of diseases such as cancer, cardiovascular disease, inflammatory disease. Specific research is still in progress.
The interacts with multiple signaling pathways, including PI3K/AKT, Wnt/β-catenin, Hippo and NF-κB, and regulates cell function and behavior.
It is a kind of protein kinases, involved in cell adhesion, movement, proliferation and survival, and many other biological processes.
This protein is associated with tumor cell proliferation, tumor angiogenesis, invasion and metastasis in tumors, and may play a role in promoting tumor development.
ILK may play an important regulatory role in organ development and regeneration, involving in cell proliferation, differentiation and maintenance of tissue structure.
For the cellular signaling mechanism of ILK, further in-depth studies are needed to clarify its specific role. In the treatment of potential, hope to be able to from the relevant regulatory mechanism of ILK, explore new targeted therapeutic strategies.
Customer Reviews (3)
Write a reviewEasy to operate, cost-effective.
It has high sensitivity and strong specificity.
High catalytic efficiency, short time, saving time.
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