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ILK

  • Official Full Name

    integrin-linked kinase

  • Overview

    Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    ILK; integrin-linked kinase; integrin-linked protein kinase; ILK-1; p59ILK; integrin-linked kinase-2; 59 kDa serine/threonine-protein kinase; P59; ILK-2; DKFZp686F1765;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ILK-12H Recombinant Human ILK, MYC/DDK-tagged HEK293 Myc/DDK
Human ILK-904H Recombinant Human Integrin-Linked Kinase, His-tagged Human His
Human ILK-5219HCL Recombinant Human ILK 293 Cell Lysate HEK293 N/A
Human ILK-5220HCL Recombinant Human ILK 293 Cell Lysate HEK293 N/A
Human ILK-2635H Recombinant Human ILK Protein (Asn183-Lys452), N-His tagged E.coli N-His Asn183-Lys452
Human ILK-5158H Recombinant Human ILK Protein, GST-tagged Wheat Germ GST
Human ILK-4906HFL Recombinant Full Length Human ILK, Flag-tagged Mamanlian cells Flag
Human ILK-1179H Recombinant Human ILK Protein (1-228 aa), His-tagged E.coli His 1-228 aa
Human ILK-5726H Recombinant Human ILK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ILK-3586H Recombinant Human ILK protein, His-tagged E.coli His 102-451 aa
Human ILK-5795HF Recombinant Full Length Human ILK Protein, GST-tagged In Vitro Cell Free System GST 452 amino acids
Mouse ILK-8187M Recombinant Mouse ILK Protein Mammalian Cell His
Mouse Ilk-3525M Recombinant Mouse Ilk Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ILK-4525M Recombinant Mouse ILK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ILK-4525M-B Recombinant Mouse ILK Protein Pre-coupled Magnetic Beads HEK293
Rat ILK-3052R Recombinant Rat ILK Protein Mammalian Cell His
Rat ILK-2708R Recombinant Rat ILK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ILK-2708R-B Recombinant Rat ILK Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ILK-2259R Recombinant Rhesus monkey ILK Protein, His-tagged Mammalian Cell His
Rhesus Macaque ILK-2080R Recombinant Rhesus Macaque ILK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ILK-2080R-B Recombinant Rhesus Macaque ILK Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ILK-10850Z Recombinant Zebrafish ILK Mammalian Cell His
Chicken ILK-5768C Recombinant Chicken ILK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ILK Related Articles
  • ILK Related Research Area

ILK involved in several pathways and played different roles in them. We selected most pathways ILK participated on our site, such as PPAR signaling pathway, Focal adhesion, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ILK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PPAR signaling pathwaySCDB;SCD;SLC27A2;CYP4A14;ACOX2;UBC;DBI;FABP3;FADS2
Focal adhesionVASPA;HRAS;CAV3;MYLPFB;Itga10&Itgb1;PARVG;PDGFRA;CAV2;VEGFAA
Bacterial invasion of epithelial cellsHCLS1;CDC42;ARPC1B;ARPC3;CTTN;BCAR1;RAC1;WAS;PIK3CB
Endometrial cancerAXIN2;PIK3CB;CASP9;NRAS;TP53;PIK3CA;TCF7;FOXO3;ARAF

ILK has several biochemical functions, for example, ATP binding, SH3 domain binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ILK itself. We selected most functions ILK had, and list some proteins which have the same functions with ILK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMAP3K10;MSH3;PRPS1L1;EPHA4B;KCNJ10;MYH13;CDC34B;DDX59;MAGI1
SH3 domain bindingSH3BP5B;OSTF1;SH3BGR;CD2AP;BCAR1;DNM2;EVL;INPP5J;CYBA
integrin bindingACTN1;ACTN3;COL4A3;ICAM4;Tcam1;FCER2;EMP2;TIMP2;WISP1B
protein bindingMRPL27;ATG101;FLII;APOBEC1;PCGF5;HHLA3;DCAF12L1;TMEM8B;SAMM50
protein kinase bindingTHY1;TELO2;GSTP2;CAMK2N1A;LLGL1;PRKAB1;MEF2A;CAV1;TPRKB
protein serine/threonine kinase activitySTK24;SLK;DYRK3;NEK10;CSNK2A1;MAPK4;IRAK2;ACVRL1;MAPK8B
signal transducer activityGPR89;ADRB2A;OLFR495;GPR132;TMTOPSA;VIPR1B;C18orf32;STAT6;CTNNB1

ILK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ILK here. Most of them are supplied by our site. Hope this information will be useful for your research of ILK.

PARVA; LIMS1

Li, T; Zhu, Y; et al. RHO KINASE ACTS AS A DOWNSTREAM MOLECULE TO PARTICIPATE IN PROTEIN KINASE C epsilon REGULATION OF VASCULAR REACTIVITY AFTER HEMORRHAGIC SHOCK IN RATS. SHOCK 42:239-245(2014).
Locatelli, M; Buelli, S; et al. Shiga Toxin Promotes Podocyte Injury in Experimental Hemolytic Uremic Syndrome via Activation of the Alternative Pathway of Complement. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 25:1786-1798(2014).
  • Q&As
  • Reviews

Q&As (6)

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In what diseases might ILK play an important role? 12/21/2019

ILK may play an important role, in a variety of diseases such as cancer, cardiovascular disease, inflammatory disease. Specific research is still in progress.

Which signaling pathways are involved in ILK? 09/23/2019

The interacts with multiple signaling pathways, including PI3K/AKT, Wnt/β-catenin, Hippo and NF-κB, and regulates cell function and behavior.

What is the function of ILK in the cell? 05/24/2019

It is a kind of protein kinases, involved in cell adhesion, movement, proliferation and survival, and many other biological processes.

What role does ILK play in tumor development? 01/13/2019

This protein is associated with tumor cell proliferation, tumor angiogenesis, invasion and metastasis in tumors, and may play a role in promoting tumor development.

Does ILK play a role in organ development and regeneration? 01/02/2019

ILK may play an important regulatory role in organ development and regeneration, involving in cell proliferation, differentiation and maintenance of tissue structure.

What are the prospects for the cellular signaling mechanism and therapeutic potential of ILK? 01/02/2019

For the cellular signaling mechanism of ILK, further in-depth studies are needed to clarify its specific role. In the treatment of potential, hope to be able to from the relevant regulatory mechanism of ILK, explore new targeted therapeutic strategies.

Customer Reviews (3)

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Reviews
08/25/2020

    Easy to operate, cost-effective.

    01/24/2020

      It has high sensitivity and strong specificity.

      10/26/2019

        High catalytic efficiency, short time, saving time.

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