Recombinant Human ILK Protein (1-228 aa), His-tagged
Cat.No. : | ILK-1179H |
Product Overview : | Recombinant Human ILK Protein (1-228 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Partial. |
- Specification
- Gene Information
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Description : | Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 30.0 kDa |
Protein length : | 1-228 aa |
AA Sequence : | MDDIFTQCREGNAVAVRLWLDNTEN DLNQGDDHGFSPLHWACREGRSAVV EMLIMRGARINVMNRGDDTPLHLAA SHGHRDIVQKLLQYKADINAVNEHG NVPLHYACFWGQDQVAEDLVANGAL VSICNKYGEMPVDKAKAPLRELLRE RAEKMGQNLNRIPYKDTFWKGTTRT RPRNGTLNKHSGIDFKQLNFLTKLN ENHSGELWKGRWQGNDIVVKVLKVR DWS |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. |
Gene Name : | ILK integrin-linked kinase [ Homo sapiens ] |
Official Symbol : | ILK |
Synonyms : | ILK; ILK-1; p59ILK; P59; ILK-2; DKFZp686F1765; |
Gene ID : | 3611 |
mRNA Refseq : | NM_001014794 |
Protein Refseq : | NP_001014794 |
MIM : | 602366 |
UniProt ID : | Q13418 |
Products Types
◆ Recombinant Protein | ||
Ilk-3525M | Recombinant Mouse Ilk Protein, Myc/DDK-tagged | +Inquiry |
ILK-2708R | Recombinant Rat ILK Protein, His (Fc)-Avi-tagged | +Inquiry |
ILK-5158H | Recombinant Human ILK Protein, GST-tagged | +Inquiry |
ILK-4525M | Recombinant Mouse ILK Protein, His (Fc)-Avi-tagged | +Inquiry |
ILK-2080R | Recombinant Rhesus Macaque ILK Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ILK-5220HCL | Recombinant Human ILK 293 Cell Lysate | +Inquiry |
ILK-5219HCL | Recombinant Human ILK 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionILK may play an important role, in a variety of diseases such as cancer, cardiovascular disease, inflammatory disease. Specific research is still in progress.
The interacts with multiple signaling pathways, including PI3K/AKT, Wnt/β-catenin, Hippo and NF-κB, and regulates cell function and behavior.
It is a kind of protein kinases, involved in cell adhesion, movement, proliferation and survival, and many other biological processes.
This protein is associated with tumor cell proliferation, tumor angiogenesis, invasion and metastasis in tumors, and may play a role in promoting tumor development.
ILK may play an important regulatory role in organ development and regeneration, involving in cell proliferation, differentiation and maintenance of tissue structure.
For the cellular signaling mechanism of ILK, further in-depth studies are needed to clarify its specific role. In the treatment of potential, hope to be able to from the relevant regulatory mechanism of ILK, explore new targeted therapeutic strategies.
Customer Reviews (3)
Write a reviewEasy to operate, cost-effective.
It has high sensitivity and strong specificity.
High catalytic efficiency, short time, saving time.
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