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Recombinant Human ILK Protein (1-228 aa), His-tagged

Cat.No. : ILK-1179H
Product Overview : Recombinant Human ILK Protein (1-228 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Partial.
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Description : Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Source : E. coli
Species : Human
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 30.0 kDa
Protein length : 1-228 aa
AA Sequence : MDDIFTQCREGNAVAVRLWLDNTEN DLNQGDDHGFSPLHWACREGRSAVV EMLIMRGARINVMNRGDDTPLHLAA SHGHRDIVQKLLQYKADINAVNEHG NVPLHYACFWGQDQVAEDLVANGAL VSICNKYGEMPVDKAKAPLRELLRE RAEKMGQNLNRIPYKDTFWKGTTRT RPRNGTLNKHSGIDFKQLNFLTKLN ENHSGELWKGRWQGNDIVVKVLKVR DWS
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Gene Name : ILK integrin-linked kinase [ Homo sapiens ]
Official Symbol : ILK
Synonyms : ILK; ILK-1; p59ILK; P59; ILK-2; DKFZp686F1765;
Gene ID : 3611
mRNA Refseq : NM_001014794
Protein Refseq : NP_001014794
MIM : 602366
UniProt ID : Q13418

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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In what diseases might ILK play an important role? 12/21/2019

ILK may play an important role, in a variety of diseases such as cancer, cardiovascular disease, inflammatory disease. Specific research is still in progress.

Which signaling pathways are involved in ILK? 09/23/2019

The interacts with multiple signaling pathways, including PI3K/AKT, Wnt/β-catenin, Hippo and NF-κB, and regulates cell function and behavior.

What is the function of ILK in the cell? 05/24/2019

It is a kind of protein kinases, involved in cell adhesion, movement, proliferation and survival, and many other biological processes.

What role does ILK play in tumor development? 01/13/2019

This protein is associated with tumor cell proliferation, tumor angiogenesis, invasion and metastasis in tumors, and may play a role in promoting tumor development.

Does ILK play a role in organ development and regeneration? 01/02/2019

ILK may play an important regulatory role in organ development and regeneration, involving in cell proliferation, differentiation and maintenance of tissue structure.

What are the prospects for the cellular signaling mechanism and therapeutic potential of ILK? 01/02/2019

For the cellular signaling mechanism of ILK, further in-depth studies are needed to clarify its specific role. In the treatment of potential, hope to be able to from the relevant regulatory mechanism of ILK, explore new targeted therapeutic strategies.

Customer Reviews (3)

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Reviews
08/25/2020

    Easy to operate, cost-effective.

    01/24/2020

      It has high sensitivity and strong specificity.

      10/26/2019

        High catalytic efficiency, short time, saving time.

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