ITGAV

  • Official Full Name

    integrin, alpha V

  • Overview

    Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V beta 3 is the predominant integrin of osteoclasts (bone resorbing cells) and is upregulated in malignant melanoma. Integrin alpha V beta 3 binds to a range of ECM proteins (e.g. vitronectin, fibrinogen, fibronectin) via an Arg-Gly-Asp (RGD) motif.
  • Synonyms

    ITGAV; integrin, alpha V; antigen identified by monoclonal L230 , integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) , MSK8, vitronectin receptor , VNRA, VTNR; integrin alpha-V; CD51; integrin alphaVbeta3; vitronectin receptor s;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • Baculovirus-Insect cells
  • CHO
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • 6×His
  • His
  • Strep
  • GST
  • His (Fc)
  • Avi
  • His|Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGAVB3-103H Active Recombinant Human ITGAVB3 CHO N/A
Human ITGAV&ITGB1-740H Active Recombinant Human ITGAV&ITGB1 CHO N/A
Human ITGAV&ITGB6-741H Active Recombinant Human ITGAV&ITGB6 CHO N/A
Human ITGAV-26862TH Recombinant Human ITGAV protein Wheat Germ N/A
Human ITGA5-101H Recombinant Human ITGAV/ITGB3 Heterodimer Protein, His-tagged HEK293 His ITGAV(Phe 31 - Val 992)/ITGB3 (Gly 27 - Asp 718)
Human ITGAV&ITGB3-739H Recombinant Human ITGAV/ITGB3 protein, His-tagged HEK293 His Phe 31 - Val 992 (ITGAV) & Gly 27 - Asp 718 (ITGB3)
Human ITGAV-6763H Recombinant Human ITGAV protein, His-tagged E.coli His Pro560~Trp744
Human ITGAV-877HCL Recombinant Human ITGAV cell lysate N/A
Human ITGAV & ITGB6-760H Active Recombinant Human ITGAV & ITGB6 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human ITGAV & ITGB5-758H Active Recombinant Human ITGAV & ITGB5 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human ITGAV-4988H Recombinant Human ITGAV Protein, GST-tagged Wheat Germ GST
Human ITGAV & ITGB1-746H Active Recombinant Human ITGAV & ITGB1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Phe31-Val992(ITGAV)&Gly27-Asp718(ITGB3)
Human ITGAV-26H Active Recombinant Human ITGAV Protein, C-6×His-tagged CHO C-6×His Integrin alpha V: Phe31-Val992<br />Integrin beta 1: Gln21-Asp728
Human ITGAV & ITGB5-336H Recombinant Human ITGAV & ITGB5 protein, His-Avi-tagged HEK293 His-Avi It contains Phe31-Val992 (P06756) acidic tail& Gly24-Asn719 (P18084) basic tail.
Human ITGAV & ITGB3-311H Recombinant Human ITGAV & ITGB3 protein, His-Avi-tagged HEK293 His-Avi It contains Phe31-Val992 (P06756) acidic tail& GLy27-Asp718 (P05106) basic tail.
Human ITGAV & ITGB3-738H Active Recombinant Human ITGAV & ITGB3 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human ITGAV-4323H Recombinant Human ITGAV Protein (Met1-Val992), C-His tagged Mammalian cells C-His Met1-Val992
Human ITGAV-2343H Recombinant Human ITGAV Protein, His-tagged E.coli N-His Phe31-Gly560
Human ITGAV-2775H Recombinant Human ITGAV protein, His-tagged E.coli His 819-915 aa
Human ITGAV-1427H Recombinant Human ITGAV Protein (891-1048 aa), His-tagged Yeast His 891-1048 aa
Human ITGAV-6962HF Recombinant Full Length Human ITGAV Protein In Vitro Cell Free System 1048 amino acids
Human ITGAV-265HF Recombinant Full Length Human ITGAV Protein In Vitro Cell Free System
Human ITGAV-301294H Recombinant Human ITGAV protein, GST-tagged E.coli GST Ser819-Gln915
Human ITGAV-5749HF Recombinant Full Length Human ITGAV Protein, GST-tagged In Vitro Cell Free System GST 1048 amino acids
Mouse ITGAV-8360M Recombinant Mouse ITGAV Protein Mammalian Cell His
Mouse Itgav-6764M Recombinant Mouse Itgav protein, His & T7-tagged E.coli His/T7 Pro71~Asp322 (Accession # P43406)
Mouse ITGAV-4641M-B Recombinant Mouse ITGAV Protein Pre-coupled Magnetic Beads HEK293
Mouse ITGAV-4641M Recombinant Mouse ITGAV Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Itgav-1700R Recombinant Rat Itgav Protein, His-tagged E.coli N-His Pro469-Leu918
Rat Itgav&Itgb6-23R Recombinant Rat Itgav&Itgb6 Protein CHO N/A
Bovine ITGAV-5819B Recombinant Bovine ITGAV and ITGB6 Protein (Phe31-Pro993, Gly22-Pro709), C-His & C-Strep tagged Mammalian cells C-His and C-Strep Phe31-Pro993, Gly22-Pro709
Bovine ITGAV-0032B Recombinant Bovine ITGAV Protein (Ala30-Pro993), C-His-tagged Baculovirus-Insect cells C-His Ala30-Pro993
Rhesus Macaque ITGAV-2315R Recombinant Rhesus monkey ITGAV Protein, His-tagged Mammalian Cell His
Rhesus Macaque ITGAV-2136R Recombinant Rhesus Macaque ITGAV Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ITGAV-2136R-B Recombinant Rhesus Macaque ITGAV Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ITGAV-3406Z Recombinant Zebrafish ITGAV Mammalian Cell His
Chicken ITGAV-6989C Recombinant Chicken ITGAV Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ITGAV involved in several pathways and played different roles in them. We selected most pathways ITGAV participated on our site, such as Phagosome, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGAV were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeATP6AP1B;ATP6V1E1B;ATP6V1C2;THBS4B;BLB2;TUBB2;RAC1B;VAMP3;TUBA7L
PIK-Akt signaling pathwayFGF22;ITGA2B;PCK2;G6PC2;RAF1;ITGAV;ITGB7;COL6A6;VEGFA
Focal adhesionRAF1B;PDGFC;COL5A2;ITGB1A;COL6A3;MAPK6;ITGB3B;PIK3R3B;PAK2A
ECM-receptor interactionITGAV;Reln;Npnt;GP1BB;COL6A1;HSPG2;COL3A1;SV2A;ITGB8
Cell adhesion molecules (CAMs)CD28;CD40LG;NRXN3;ITGB8;BF2;HLA-G;ITGAV;PVRL3B;NRXN2
Regulation of actin cytoskeletonITGA6;F2R;RAF1;PPP1R12A;GNG12;ARPC5L;ARHGEF12;NRAS;GSN
Thyroid hormone signaling pathwayBAD;PLCD4;ESR1;HIF1A;NOTCH1;PRKCG;ATP1A4;ACTB;HDAC1
Pathways in cancerLAMA2;MAPK8;RALGDS;CDC42;WNT5B;TCF7L2;IL6;STK36;WNT7A
Proteoglycans in cancerHOXD10;GPC1;Casp3;FZD6;PIK3CB;VEGFA;PIK3R3;SMO;PTPN11
Small cell lung cancerCCNE1;NFKBIA;PIK3R1;NFKB1;RARB;RXRA;LAMA5;TRAF5;ITGB1
Hypertrophic cardiomyopathy (HCM)IGF1;DMD;ITGA2B;PRKAG3;CACNA2D3;TGFB2;SGCA;TPM3;ACE
Arrhythmogenic right ventricular cardiomyopathy (ARVC)GJA1;ITGB4;ITGB3;SLC8A1;CTNNA3;LMNA;ACTN4;CACNG6;CACNA2D1
Dilated cardiomyopathyDAG1;CACNB2;MYH7;MYBPC3;DMD;ITGA2B;ITGA4;ACTG1;DES

ITGAV has several biochemical functions, for example, extracellular matrix binding, extracellular matrix protein binding, fibronectin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGAV itself. We selected most functions ITGAV had, and list some proteins which have the same functions with ITGAV. You can find most of the proteins on our site.

Function Related Protein
extracellular matrix bindingCD248;ITGA2B;SPP1;TGFBI;GPR56;VTN;SPOCK2;SID4;FBLN2
extracellular matrix protein bindingMEPE;ITGB8;ITGAV
fibronectin bindingIGFBP5;HSD17B12;SDC4;FBLN1;PLEKHA2;CTSK;ITGA3;SFRP2;CCDC80
contributes_to insulin-like growth factor I binding
metal ion bindingMOBKL2B;CPXCR1;BRIP1;ZSCAN2;YY1B;CNDP1;SP1;EPT1;TAF1B
contributes_to opsonin binding
protease bindingTIMP2;THAP5;UBC;SERPINB3;SEMG2;BCL10;FN1;CAST;TP53
protein bindingPTH2R;SOX7;LARS;ACTR3;POLR3C;DDX20;SULT1A2;ZNF69;MNDA
contributes_to protein kinase C binding
transforming growth factor beta bindingLTBP4;THBS1;TGFBR2;ENG;VASN;ITGAV;TGFB3;HYAL2;TGFBR3
virus receptor activityITGA2;ANPEP;XPR1;DPP4;TFRC;IDE;ITGB1;CCR5;TNFRSF4
voltage-gated calcium channel activityITGAV;CACNB1;CACNA1BA;CACNA1SB;TPC3;NALCN;CACNG1;CACNG1A;IL1RAPL1

ITGAV has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGAV here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGAV.

ITGB3; FN1; ITGB5; PPAP2B; VTN; VWF; PTPRZ1

Research Area

Related articles

Shakiba, E; Tavilani, H; et al. The ITGAV-rs3911238 Polymorphism Is Associated with Disease Activity in Rheumatoid Arthritis. IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY 13:356-363(2014).
Inamine, T; Nakamura, M; et al. A polymorphism in the integrin alpha V subunit gene affects the progression of primary biliary cirrhosis in Japanese patients. JOURNAL OF GASTROENTEROLOGY 46:676-686(2011).
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