LILRB1

  • Official Full Name

    leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1

  • Overview

    This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    LILRB1; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; leukocyte immunoglobulin-like receptor subfamily B member 1; CD85; CD85j; ILT2; LIR 1; LIR1; MIR 7; ILT-2; CD85 antigen; Ig-like transcript 2; leukocyte Ig-like receptor-1; immunoglobulin-like transcript 2; CD85 antigen-like family member J; leukocyte immunoglobulin-like receptor 1; monocyte/macrophage immunoglobulin-like receptor 7; leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform; MIR7; LIR-1; MIR-7; FLJ37515;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Cynomolgus
  • Human
  • Rhesus Macaque
  • Rhesus monkey
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human cells
  • Human Cells
  • Insect cells
  • Mammalian cells
  • Avi|Fc
  • C
  • His
  • Fc
  • hIgG1
  • hIgG4
  • His|T7
  • Avi
  • human|IgG1|Fc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LILRB1-0622H Recombinant Human LILRB1 protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
Human LILRB1-110H Recombinant Human LILRB1 protein, Fc-tagged HEK293 human/IgG1/Fc
Human LILRB1-7871H Recombinant Human LILRB1, His-tagged HEK293 His
Human LILRB1-109H Recombinant Human LILRB1 protein, His-tagged, Biotinylated HEK293 His
Human LILRB1-6900H Recombinant Human LILRB1 protein, His & T7-tagged E.coli His/T7
Human LILRB1-774HCL Recombinant Human LILRB1 cell lysate Human Cell N/A
Human LILRB1-152H Recombinant Human LILRB1 Protein, His-tagged Human cells His
Human LILRB1-646H Recombinant Human LILRB1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human LILRB1-086H Recombinant Human LILRB1 protein, Fc-tagged HEK293 Fc
Human LILRB1-5052H Recombinant Human LILRB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LILRB1-151H Recombinant Human LILRB1 Protein, His-tagged Human Cells His
Human LILRB1-028H Active Recombinant Human LILRB1 Protein, His-tagged Insect cells His
Human LILRB1-087H Recombinant Human LILRB1 protein, His-Avi-tagged HEK293 His-Avi
Human LILRB1-353H Recombinant Human LILRB1 Protein, Fc-tagged HEK293 Fc
Human LILRB1-087HB Recombinant Human LILRB1(Gly24-His458) Protein, C-6*His-Avi-tagged, Biotinylated HEK293 His-Avi
Human LILRB1-109HB Recombinant Human LILRB1 protein, His-tagged, Biotinylated HEK293 His
Human LILRB1-1248H Recombinant Human LILRB1 Protein (Ser223-His410), N-His tagged E.coli N-His
Human LILRB1-3670H Recombinant Human LILRB1 protein, His-tagged E.coli His
Human LILRB1-3935H Recombinant Human LILRB1 Protein (Met1-Val461), C-His tagged Mammalian cells C-His
Human LILRB1-0332H Recombinant Human LILRB1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
Human LILRB1-3936H Recombinant Human LILRB1 Protein (Gly24-His458), C-His tagged Mammalian cells C-His
Human LILRB1-0334H Active Recombinant Human LILRB1 protein, Fc-tagged HEK293 Fc
Rhesus monkey LILRB1-1822R Recombinant Rhesus Monkey LILRB1 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey LILRB1-1821R Recombinant Rhesus Monkey LILRB1 Protein HEK293 N/A
Rhesus monkey LILRB1-1823R Recombinant Rhesus Monkey LILRB1 Protein, hIgG4-tagged HEK293 hIgG4
Cynomolgus LILRB1-0333C Recombinant Cynomolgus LILRB1 protein, His-tagged HEK293 His
Rhesus Macaque LILRB1-01R Recombinant Rhesus Macaque LILRB1 protein, His-tagged HEK293 His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LILRB1 Related Articles
  • LILRB1 Related Research Area

LILRB1 involved in several pathways and played different roles in them. We selected most pathways LILRB1 participated on our site, such as Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with LILRB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemFBXO3;CD300E;UBE2U;CLEC2B;KIF26A;CTSL2;ARF1;DTX3L;LRRC41
Immune SystemRAP1GAP2;CRP;BFB;KIF4A;CFHL2;CD300LG;C1rb;EIF4E3;KLRG1
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellLILRA2;SIGLEC7;RAET1E;CD300LG;ICAM4;KLRB1A;CLEC2H;TREML4;SIGLEC9
Osteoclast differentiationRELB;SIRP-BETA;SPI1;FCGR2B;OSCAR;AKT2;MAPK11;TAB2;FCGR3B

LILRB1 has several biochemical functions, for example, HLA-A specific inhibitory MHC class I receptor activity, HLA-B specific inhibitory MHC class I receptor activity, MHC class I protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LILRB1 itself. We selected most functions LILRB1 had, and list some proteins which have the same functions with LILRB1. You can find most of the proteins on our site.

Function Related Protein
HLA-A specific inhibitory MHC class I receptor activity
HLA-B specific inhibitory MHC class I receptor activityLILRB1;KIR3DL1
MHC class I protein bindingPilrb1;BCAP31;ATP5B;ATP5A1;CD8A;TAP1;LILRB2;PILRB;CD8B
MHC class I receptor activityKLRF1;LILRB1;MR1;KIR3DS1;CD160
SH2 domain bindingSH3PXD2B;SKAP1;SHCBP1;INPPL1;SQSTM1;CRK;CTR9;MS4A2;LCK
protein homodimerization activitySMAD2;IGJ;TIMELESS;ASGR1;DAXX;TKT;TARS;GSS;VPS24
protein phosphatase 1 bindingSTAU1;TCTEX1D4;SH3RF2;PPP1R11;FER;PHACTR4;PHACTR1;SHOC2;PHACTR3

LILRB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LILRB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LILRB1.

CSK; HLA-G; uup; q81vw1_bacan

Chan, KR; Ong, EZ; et al. Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:2722-2727(2014).
Li, NL; Fu, L; et al. Cis association of leukocyte Ig-like receptor 1 with MHC class I modulates accessibility to antibodies and HCMV UL18. EUROPEAN JOURNAL OF IMMUNOLOGY 43:1042-1052(2013).
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