LILRB1
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Official Full Name
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
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Overview
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
LILRB1; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; leukocyte immunoglobulin-like receptor subfamily B member 1; CD85; CD85j; ILT2; LIR 1; LIR1; MIR 7; ILT-2; CD85 antigen; Ig-like transcript 2; leukocyte Ig-like receptor-1; immunoglobulin-like transcript 2; CD85 antigen-like family member J; leukocyte immunoglobulin-like receptor 1; monocyte/macrophage immunoglobulin-like receptor 7; leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform; MIR7; LIR-1; MIR-7; FLJ37515;
- Recombinant Proteins
- Cell & Tissue Lysates
- Cynomolgus
- Human
- Rhesus Macaque
- Rhesus monkey
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human cells
- Human Cells
- Insect cells
- Mammalian cells
- Avi|Fc
- C
- His
- Fc
- hIgG1
- hIgG4
- His|T7
- Avi
- human|IgG1|Fc
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- LILRB1 Related Articles
- LILRB1 Related Research Area
LILRB1 involved in several pathways and played different roles in them. We selected most pathways LILRB1 participated on our site, such as Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with LILRB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adaptive Immune System | STIM1B;STUB1;CD300C;TREML4;RNF25;LILRB4;CLEC2H;SIGLEC5;MICA |
Immune System | CYLD;TRIM63;TNFRSF13C;DCTN6;BTR22;HECTD3;LTN1;DUSP3B;PCBP2 |
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | LAIR1;LILRA2;LAIR2;CD200R2;SLAMF6;CD200;CD226;CD300E;CLEC2B |
Osteoclast differentiation | FOSL1;MAPK12;IL1A;TYROBP;TGFBR2;MAP3K14;FCGR3;MAPK11;IL1B |
LILRB1 has several biochemical functions, for example, HLA-A specific inhibitory MHC class I receptor activity, HLA-B specific inhibitory MHC class I receptor activity, MHC class I protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LILRB1 itself. We selected most functions LILRB1 had, and list some proteins which have the same functions with LILRB1. You can find most of the proteins on our site.
Function | Related Protein |
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HLA-A specific inhibitory MHC class I receptor activity | |
HLA-B specific inhibitory MHC class I receptor activity | LILRB1;KIR3DL1 |
MHC class I protein binding | BCAP31;TUBB;CD244;PILRB;TUBB4B;LILRB2;TAP1;CD8A;VCP |
MHC class I receptor activity | KLRF1;LILRB1;KIR3DS1;CD160;MR1 |
SH2 domain binding | LCK;TRPV4;NUP62;SHCBP1;IRS1;SYNGR3;LILRB1;MS4A2;SQSTM1 |
protein homodimerization activity | ALS2;SDS;PSPH;MYO7A;EIF2AK1;GABPB2;BCL2L2;HSD17B4;UGT1A6 |
protein phosphatase 1 binding | PPP1R15A;PHACTR4B;KCNQ1;SH3RF2;PHACTR4;FER;PPP1R11;Fert2;TCTEX1D4 |
LILRB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LILRB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LILRB1.
CSK; HLA-G; uup; q81vw1_bacan
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