Recombinant Human leukocyte immunoglobulin like receptor B1 Protein, His&Flag tagged
Cat.No. : | LILRB1-131H |
Product Overview : | Recombinant human LILRB1/CD85j/ILT2 protein (Q8NHL6) (Gly 24-Vla 461) with both His and Flag tag at the C-terminus was expressed in HEK293. |
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Description : | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide. Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells. Reprograms B cells toward an immune suppressive phenotype. |
Source : | HEK293 |
Species : | Human |
Tag : | C-His&Flag |
Protein length : | 24-461aa |
Molecular Mass : | 50.2 kDa |
Endotoxin : | Less than 1.0 EU/μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol. |
Reconstitution : | Reconstitute at 250 μg/mL in sterile water. |
Gene Name : | LILRB1 leukocyte immunoglobulin like receptor B1 [ Homo sapiens (human) ] |
Official Symbol : | LILRB1 |
Synonyms : | LILRB1; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; leukocyte immunoglobulin-like receptor subfamily B member 1; CD85; CD85j; ILT2; LIR 1; LIR1; MIR 7; ILT-2; CD85 antigen; Ig-like transcript 2; leukocyte Ig-like receptor-1; immunoglobulin-like transcript 2; CD85 antigen-like family member J; leukocyte immunoglobulin-like receptor 1; monocyte/macrophage immunoglobulin-like receptor 7; leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform; MIR7; CD85J; LIR-1; MIR-7; FLJ37515; |
Gene ID : | 10859 |
mRNA Refseq : | NM_001081637 |
Protein Refseq : | NP_001075106 |
MIM : | 604811 |
UniProt ID : | Q8NHL6 |
Products Types
◆ Recombinant Protein | ||
LILRB1-4633H | Recombinant Human LILRB1 protein, His-tagged | +Inquiry |
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LILRB1-086H | Recombinant Human LILRB1 protein, hFc-tagged | +Inquiry |
LILRB1-028H | Active Recombinant Human LILRB1 Protein, His-tagged | +Inquiry |
LILRB1-01R | Recombinant Rhesus macaque LILRB1 protein, His-tagged | +Inquiry |
◆ Lysates | ||
LILRB1-774HCL | Recombinant Human LILRB1 cell lysate | +Inquiry |
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