Recombinant Human LILRB1 protein, Fc & Avi-tagged, Biotinylated
Cat.No. : | LILRB1-0622H |
Product Overview : | Biotinylated Human LILRB1 , Fc Tag is expressed from human 293 cells (HEK293). It contains AA Gly 24 - His 458 (Accession # D9IDM5-1). Biotinylation of this product is performed using Avitag technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin. The biotin to protein ratio is 0.5-1 as determined by the HABA assay. |
- Specification
- Gene Information
- Related Products
Description : | CD85 antigen-like family member J (CD85J) is also known as Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1 or LIR-1), Immunoglobulin-like transcript 2 (ILT-2), Monocyte/macrophage immunoglobulin-like receptor 7 (MIR7), which belongs to leukocyte immunoglobulin-like receptor (LIR) family. CD85J / LILRB1 Contains 4 Ig-like C2-type (immunoglobulin-like) domains. CD85J / LIR-1 is expressed predominantly on B-cells and monocytes. CD85J is receptor for class I MHC antigens and recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles and is also receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. CD85J / LILRB1 interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. CD85J / LILRB1 inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. |
Source : | HEK293 |
Species : | Human |
Tag : | Fc & Avi |
Predicted N Terminal : | Gly 24 |
Form : | Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 75.6 kDa. As a result of glycosylation, the protein migrates as 100-116 KDa under reducing (R) condition, and 150 KDa under non-reducing (NR) condition (SDS-PAGE). |
Protein length : | Gly 24 - His 458 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. No activity loss is observed after storage at: 4-8°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Shipping : | Powder,RT |
Gene Name : | LILRB1 leukocyte immunoglobulin like receptor B1 [ Homo sapiens (human) ] |
Official Symbol : | LILRB1 |
Synonyms : | ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B; leukocyte immunoglobulin-like receptor subfamily B member 1; CD85 antigen-like family member J; Ig-like transcript 2; leucocyte Ig-like receptor B1; leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; monocyte/macrophage immunoglobulin-like receptor 7; myeloid inhibitory receptor 7 |
Gene ID : | 10859 |
mRNA Refseq : | NM_001081637.2 |
Protein Refseq : | NP_001075106.2 |
UniProt ID : | Q8NHL6 |
Products Types
◆ Recombinant Protein | ||
LILRB1-646H | Recombinant Human LILRB1 Protein, MYC/DDK-tagged | +Inquiry |
LILRB1-353H | Recombinant Human LILRB1 Protein, Fc-tagged | +Inquiry |
LILRB1-028H | Active Recombinant Human LILRB1 Protein, His-tagged | +Inquiry |
LILRB1-0333C | Recombinant Cynomolgus LILRB1 protein, His-tagged | +Inquiry |
LILRB1-152H | Recombinant Human LILRB1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
LILRB1-774HCL | Recombinant Human LILRB1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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