LILRB3
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Official Full Name
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 -
Overview
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
LILRB3;leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3;leukocyte immunoglobulin-like receptor subfamily B member 3;CD85a;HL9;ILT5;LIR 3;LIR3;CD85 antigen like family member A;CD85a antigen;IL T5;Immunoglobulin like transcript 5;Leukocyte immunoglobulin like receptor 3;Leukocyte immunoglobulin like receptor subfamily B (with TM and ITIM domains) member 3;Leukocyte immunoglobulin like receptor subfamily B member 3;MGC138403;Monocyte inhibitory receptor HL9;PIRB;ILT-5;OTTHUMP00000069587;OTTHUMP00000197712;OTTHUMP00000237014;immunoglobulin-like transcript 5;CD85 antigen-like family member A;leukocyte immunoglobulin-like re;LIR-3
Recombinant Proteins
- Human
- Mouse
- HEK293
- Mammalian cells
- E.coli
- Human Cell
- Mouse
- Yeast
- E.coli expression system
- His
- Fc
- His&Avi
- Fc&Avi
- Non
- His&Fc&Avi
Involved Pathway
LILRB3 involved in several pathways and played different roles in them. We selected most pathways LILRB3 participated on our site, such as Adaptive Immune System,B cell receptor signaling pathway,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with LILRB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| B Cell Receptor Signaling Pathway | CSK,DAPP1,RAC2,BLK,LCP2A,PPP3R1,ARPC1B,HRAS,PDPK1A,NRAS |
| Immune System | POLR3H,PJA2,CTSH,DDX41,CD300LB,KIF2C,LAIR1,PPAPDC1B,SIGLEC10,AF251705 |
| Osteoclast differentiation | PPP3CA,LILRA4,CYBB,OSCAR,RAC1,FCGR1A,SQSTM1,NFKB2,SIRPB1,NOX1 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | PVRL2L,MICA,SIGLEC6,SIGLEC10,TREML4,KLRF1,TREML2,SIGLEC7,CLEC2H,SLAMF6 |
| Spinal Cord Injury | GAP43,RTN4,NOX4,PTPRZ1,OMG,KLK8,RTN4R,MBP,RGMA,LGALS3 |
| Adaptive Immune System | AP2S1,ASB6,UBR2,CD200R4,ASB10,CDKN1B,KIF20A,CTSO,AP1G1,ATG7 |
Protein Function
LILRB3 has several biochemical functions, for example, protein binding,receptor activity,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LILRB3 itself. We selected most functions LILRB3 had, and list some proteins which have the same functions with LILRB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | MPL,CD72,GIPR,FZD1,TLR10,TLR3,FZD7B,AGER,VIPR1B,TNFRSF10C |
| protein binding | RBP5,ATP6V0D1,LRSAM1,TBPL1,KLF5,VASP,AKT1S1,SLX4,MUM1,PIF1 |
| receptor activity | PAQR3B,OR3A2,MCC,CD1D,ANPEP,ITGB3B,TMEM123,RTN4R,ITGB1B,NPC1 |
Interacting Protein
LILRB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LILRB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LILRB3.
q81jv5_bacan
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesCo-stimulatory ILT/CD85 Family Proteins
MHC Class I
MHC Class II
T Cell Antigen Recognition
Co-stimulatory Molecules
Macrophage Markers
Monocyte Markers
Other Proteins Involved in Regulating B Cell Activation
Dendritic Cell ITIM/ITAM Immunoreceptors
Dendritic Cell Pathogen Recognition/Uptake
Related Services
Related Products
References
