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MAP2K2

  • Official Full Name

    MAP2K2 mitogen-activated protein kinase kinase 2

  • Overview

    MEK (MAP Kinase Kinase) phosphorylates the MAP Kinase on both threonine and tyrosine residues of the activation motif TEY. MEK1 and MEK2 are activated by phosphorylation of two serine residues (Ser 218/222 in MEK1 and Ser 222/226 in MEK2). These phosphorylation sites are substrates of the Raf family of kinases.
  • Synonyms

    MAP2K2; mitogen-activated protein kinase kinase 2; PRKMK2; dual specificity mitogen-activated protein kinase kinase 2; MEK2; MAPK/ERK kinase 2; MAP kinase kinase 2; ERK activator kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK2; MAPKK2; FLJ26075;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP2K2-106HFL Active Recombinant Full Length Human MAP2K2 Protein, N-His-tagged Sf21 His Full Length
Human MAP2K2-107HFL Unactive Recombinant Full Length Human MAP2K2 Protein, N-His-tagged Sf21 His Full Length
Human MAP2K2-29202TH Recombinant Human MAP2K2 N/A
Human MAP2K2-1316H Recombinant Human Mitogen-Activated Protein Kinase Kinase 2, His-tagged E.coli His
Human MAP2K2-968H Recombinant Human MAP2K2 protein(Met1-Val400), GST-tagged Insect Cells N-GST Met1-Val400
Human MAP2K2-350H Recombinant Human MAP2K2, GST-tagged, Active Sf9 Insect Cell GST
Human MAP2K2-15860H Recombinant Human MAP2K2, His-tagged E.coli His 1-400aa
Human MAP2K2-301H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli His/MBP 1-171 aa
Human MAP2K2-302H Recombinant Human MAP2K2 protein, His/MBP-tagged E.coli His/MBP 262-400 aa
Human MAP2K2-613HCL Recombinant Human MAP2K2 cell lysate Insect Cell N/A
Human MAP2K2-1645HFL Recombinant Full Length Human MAP2K2 Protein, C-Flag-tagged Mammalian cells Flag
Human MAP2K2-968HAF555 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 555 conjugated Insect Cells GST 624
Human MAP2K2-968HAF488 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 488 conjugated Insect Cells GST 624
Human MAP2K2-5651HF Active Recombinant Full Length Human MAP2K2 Protein, GST-tagged Insect (sf21) GST 1-400
Human MAP2K2-0227H Recombinant Human MAP2K2 Protein (E55-V400), His tagged E.coli His E55-V400
Human MAP2K2-968HAF647 Recombinant Human MAP2K2 Protein, GST-tagged, Alexa Fluor 647 conjugated Insect Cells GST 624
Human MAP2K2-1353H-B Recombinant Human MAP2K2 Protein Pre-coupled Magnetic Beads HEK293
Human MAP2K2-0226H Recombinant Human MAP2K2 Protein (E55-V400), Tag Free E.coli No tag E55-V400
Human MAP2K2-968HF Recombinant Human MAP2K2 Protein, GST-tagged, FITC conjugated Insect Cells GST 624
Human MAP2K2-5003H Recombinant Human MAP2K2 Protein (Val86-Pro331), N-His tagged E.coli N-His Val86-Pro331
Human MAP2K2-1353H Recombinant Human MAP2K2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAP2K2-253H Recombinant Human MAP2K2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAP2K2-4024H Recombinant Human MAP2K2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Map2k2-8085M Recombinant Mouse Map2k2 protein, His-tagged E.coli His Leu44~Ser313
Mouse Map2k2-3921M Recombinant Mouse Map2k2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat MAP2K2-3560R Recombinant Rat MAP2K2 Protein Mammalian Cell His
Rat MAP2K2-3216R Recombinant Rat MAP2K2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MAP2K2-3216R-B Recombinant Rat MAP2K2 Protein Pre-coupled Magnetic Beads HEK293
Chicken MAP2K2-6940C Recombinant Chicken MAP2K2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAP2K2 Related Research Area

MAP2K2 involved in several pathways and played different roles in them. We selected most pathways MAP2K2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPPM1NB;CACNA1G;PLA2G4F;CACNA1D;TGFBR2;HSPA1B;RPS6KA2;AKT2L;CACNB3
ErbB signaling pathwayNCK2;CAMK2G1;MAPK8A;PIK3R3;AKT1;RAF1B;GSK3B;MAP2K2B;ERBB3B
Ras signaling pathwayPDGFRA;RASAL1;NGF;PDGFB;GNG7;RAF1;ELK1;IKBKG;FASLG
Rap signaling pathwayPIK3CB;FGF3;RHOA;LPAR3;AKT2;IGF1R;ITGA2B;PDGFB;CALM4
cGMP-PKG signaling pathwayIRS2;ATP1A1;MYLK3;AKT1;IRS1;ITPR1;KCNJ8;ATP2B4;IRS4
cAMP signaling pathwayBDNF;ARAP3;PIK3R2;GRIN1;GPR119;HTR1A;Adcy4;MAPK3;F2R
HIF- signaling pathwayARNT;IL6R;INS;PRKCB;HK3;IFNG;TEK;TF;TIMP1
FoxO signaling pathwayFOXO3A;CCNB3;STK11;PTENA;CCND1;AKT1;RBL2;KLF2;PIK3R3A
Sphingolipid signaling pathwaySPTLC3;GNA12;PLCB2;PPP2R1A;CERS4;ACER1;FCER1G;PPP2R2B;LOC100328615
Phospholipase D signaling pathwayPIK3R5;F2R;RRAS2;PDGFD;PLA2G4A;SHC4;LPAR2;PLA2G4C;CYTH3
PIK-Akt signaling pathwayG6PC3;PPP2R2A;ITGA2B;ITGAV;PGF;INS;FGFR1;Pdgfa&Pdgfb;ITGB4
Vascular smooth muscle contractionROCK2A;ACTA2;PPP1R14AA;PLCB3;ADCY1B;ARHGEF1;BRAF;PTGIR;PLA2G2A
VEGF signaling pathwaySHC2;MAP2K2A;BADB;HRASA;PXN;PLCG1;RAC1B;PIK3R2;RAC3B
Gap junctionTUBB6;ITPR3;GNAI1;GRB2A;TUBAL3;ADRB3B;GUCY1B3;GJA1;TUBA8
Signaling pathways regulating pluripotency of stem cellsBMI1;LIFR;PIK3CG;INHBA;PCGF6;PAX6;FZD1;WNT9B;LIF
Toll-like receptor signaling pathwayTICAM2;CXCL8B.3;CCL4L2;CRFB2;MAP2K1;PIK3CD;MAPK8B;IRAK1;IFNAR1
Natural killer cell mediated cytotoxicityMICA;KIR2DS3;FCGR3;BID;PTPN6;FCGR4;KIR3DL2;VAV1;FAS
T cell receptor signaling pathwayCBL;CD3G;MAPK3;PLCG1;PPP3CA;FOS;PPP3CB;CD3E; CD3D;DEF6A
B cell receptor signaling pathwayARPC3;ARPC2;BLK;AKT2;PRKCB;cgr2b;ARPC4;PLEKHA2;LIME1
Fc epsilon RI signaling pathwayPIK3R1;PDPK1;MAPK9;HRAS;LYN;RAC1;MAP2K1;MAP2K3;TNF
Long-term potentiationEP300;MAPK3;RPS6KA1;CALM4;PPP1R1A;ARAF;PPP1CA;CAMK2B;GRIN2A
Neurotrophin signaling pathwayCALML3;CAMK2G;MAPK10;KRAS;RAPGEF1;IKBKB;MATK;MAPK12;NGF
Long-term depressionPPP1R17;GNAQ;NRAS;MAPK3;MAP2K2;GRIA1;GRIA3;GNA13;PPP2R1A
Regulation of actin cytoskeletonPIP5K1B;F2R;ARPC5LB;MYH10;CHRM5B;ARPC5LA;MYL7;DIAPH1;LIMK2
Insulin signaling pathwayCALM3A;SOCS1A;RPS6KB1B;NRAS;PPP1R3C;G6PC3;FBP2;MKNK2A;SOCS3
GnRH signaling pathwayPLD2;PLA2G4AA;ITPR1;MAP3K4;CACNA1D;PTK2BB;MAPK3;GNA11A;GNRHR1
Estrogen signaling pathwayCALML3;PLCB2;PLCB4;MAP2K2;HSPA8;PIK3CB;PRKCD;ESR2;PIK3CG
MelanogenesisCAMK2B;TCF7;TYR;DVL3A;PLCB4;FZD5;POMC;FZD3;WNT4A
Prolactin signaling pathwaySOCS5;SOCS6;RELA;MAPK1;SOCS4;MAP2K2;NRAS;SOCS7;GSK3B
Thyroid hormone signaling pathwayKRAS;MED4;MTOR;TP53;STAT1;PIK3R2;DIO3;RCAN1;ATP1A4
Oxytocin signaling pathwayCALM3;CACNA2D3;CAMK2D;NFATC3;ITPR3;MAP2K2;PLA2G4C;RYR1;PIK3R5
Prion diseasesBAX;C1QB;PRNP;IL1B;C8A;C9;C6;MAPK1;HSPA1A
Hepatitis BFasl;MAPK9;IFNA4;MAPK3;BIRC5;OSTN;IFNA14;CREB5;FAS
Influenza AHSPA1B;Ifna15;NUP98;TNFRSF10C;ICAM1;IFN-a;OAS1A;PML;IFIH1
Pathways in cancerPLD1;WNT8B;FGF11;TRP53;ITGA2;HDAC1;GNGT2;STK36;CBLB
Proteoglycans in cancerFLNA;FGFR1;ARAF;WNT6;LUM;SDC2;CAMK2B;FZD5;HIF1A
MicroRNAs in cancerBMI1;CCND1;SOCS1;SERPINB5;IKBKB;GLS;Abcb1b;NRAS;SIRT1
Renal cell carcinomaAKT1;HIF1A;RAC1;TGFB1;RBX1;PIK3CD;VHL;PAK3;NRAS
Endometrial cancerGRB2;LEF1;MAP2K1;ARAF;PDPK1;TRP53;ILK;PIK3CA;PIK3R1
GliomaPIK3CG;CAMK2G;CALM1;AKT2;RAF1;SHC2;CALM2;TRP53;CALML5
Prostate cancerBCL2;INS1;SPRY1;MTOR;NRAS;PIK3R2;INS;ERBB2;ARAF
Thyroid cancerKRAS;BRAF;NTRK1;LEF1;PAX8;TPR;TCF7;MAPK1;CCDC6
MelanomaPIK3CG;FGF8;FGF16;FGF4;PDGFRA;FGF11;FGF13;PIK3CD;TP53
Bladder cancerMAP2K2;MDM2;MAPK3;CDKN2A;CXCL8;SRC;DAPK2;E2F1;MMP1
Chronic myeloid leukemiaABL1;PIK3CB;MAP2K1;KRAS;CRK;PIK3CD;TGFBR2;PIK3CG;IKBKG
Acute myeloid leukemiaZBTB16;SPI1;BRAF;PML;KIT;MAPK1;RELA;RPS6KB2;RUNX1T1
Non-small cell lung cancerALK;PRKCG;TRP53;SOS1;STK4;RXRG;BRAF;GRB2;PIK3R5
Central carbon metabolism in cancerPFKM;NTRK1;SLC2A2;KRAS;TRP53;IDH1;HKDC1;GLS;MET
Choline metabolism in cancerPIK3CG;DGKA;SLC22A2;PLCG1;MAP2K2;RAC1;PIP5K1B;RPS6KB1;SLC5A7

MAP2K2 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K2 itself. We selected most functions MAP2K2 had, and list some proteins which have the same functions with MAP2K2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTTLL9;CAMK2B;HSPA12B;P2RX4B;CDC42BPG;HCK;SRPK3;PAK6;DDX19B
MAP kinase kinase activityMAP3K14;MAP3K9;ALPK2;MAPK10;MAP2K2B;MAP2K1;MAP2K2A;LRRK2;MAP2K3
PDZ domain bindingCCDC88C;ATP2B4;LIN7B;SLC22A5;SLC26A6;Apba1;PROSAPIP1;GRIA1;CXXC4
metal ion bindingGH1;JAZF1A;ZNF497;ATP1A1A.3;ZNF37A;ADO;PPP2R3C;BCL11BA;THAP2
protein bindingPODXL2;SAC3D1;DSC2;RAMP3;ZSCAN16;DALRD3;TFIP11;RAD50;UACA
protein complex scaffoldAKAP1;MAP2K2;GNB2L1;MAGI3;AKAP9;SLC9A3R2;ARRB2;TELO2;SLC9A3R1
protein serine/threonine kinase activator activityCDK5R1;CALM1;CALM3;SPRY2;IGF2;MAP2K2;CAB39;MAP2K1;CALM2
protein serine/threonine kinase activityLIMK2;NEK11;NEK3;AKT1;MAP3K10;ATM;PRKCA;SNRK;PRKCHA
protein serine/threonine/tyrosine kinase activityCLK1;AURKB;PRKAA2;AURKC;DYRK1B;RPS6KA2;MAP2K1;PRKCG;DYRK3
protein tyrosine kinase activityMAP2K2;EPHA7;MET;ERBB3A;EPHB4B;FER;EK1;ERBB2;IGF1RB
scaffold protein bindingNOS1;SHANK3;HOMER1;KRT15;PDE4D;CACNA1H;DLG4;NLGN1;NLGN3

MAP2K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K2.

ARAF; RAF1; BRAF; CCNDBP1; COPS5

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