MAP2K5

  • Official Full Name

    MAP2K5 mitogen-activated protein kinase kinase 5

  • Overview

    Mitogen-activated protein kinase kinase 5 (MKK5) belongs to the serine/threonine protein kinase family and the MAPK subfamily (MAP2K, MKK or MEKs). MKK5 specifically phosphorylates erk5/MAPK7 within the kinase activation loop pThr-E-pTyr motif. After activation erk5 phosphorylates MKK5 on multiple phosphoserine residues. The MKK5/erk5 pathway may play an important role in prostate and breast cancer.
  • Synonyms

    MAP2K5; mitogen-activated protein kinase kinase 5; PRKMK5; dual specificity mitogen-activated protein kinase kinase 5; HsT17454; MAPKK5; MEK5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase 5; MAP kinase kinase MEK5b;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • HEK293
  • Human
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cells
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP2K5-597H Recombinant Human MAP2K5 Mammalian Cell His
Human MAP2K5-29560TH Recombinant Human MAP2K5 Wheat Germ N/A
Human MAP2K5-492H Recombinant Human Mitogen-Activated Protein Kinase kinase 5, His-tagged Human His
Human MAP2K5-4509HCL Recombinant Human MAP2K5 293 Cell Lysate HEK293 N/A
Human MAP2K5-3431H Recombinant Human MAP2K5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAP2K5-2401HF Active Recombinant Full Length Human MAP2K5 Protein, GST-tagged Insect (sf21) GST
Human MAP2K5-003H Recombinant Human MAP2K5 Protein, GST-tagged Wheat Germ GST
Human MAP2K5-001H Recombinant Human MAP2K5 Protein, GST-tagged Insect Cells GST
Human MAP2K5-295HF Recombinant Full Length Human MAP2K5 Protein In Vitro Cell Free System
Human MAP2K5-6842HF Recombinant Full Length Human MAP2K5 Protein, GST-tagged In Vitro Cell Free System GST
Human MAP2K5-3431H-B Recombinant Human MAP2K5 Protein Pre-coupled Magnetic Beads HEK293
Mouse MAP2K5-9502M Recombinant Mouse MAP2K5 Protein Mammalian Cell His
Mouse MAP2K5-5325M Recombinant Mouse MAP2K5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MAP2K5-5325M-B Recombinant Mouse MAP2K5 Protein Pre-coupled Magnetic Beads HEK293
Rat MAP2K5-3561R Recombinant Rat MAP2K5 Protein Mammalian Cell His
Rat MAP2K5-3217R-B Recombinant Rat MAP2K5 Protein Pre-coupled Magnetic Beads HEK293
Rat MAP2K5-3217R Recombinant Rat MAP2K5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey MAP2K5-676C Recombinant Cynomolgus MAP2K5 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey MAP2K5-422C-B Recombinant Cynomolgus Monkey MAP2K5 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey MAP2K5-422C Recombinant Cynomolgus Monkey MAP2K5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish MAP2K5-6382Z Recombinant Zebrafish MAP2K5 Mammalian Cell His
Chicken MAP2K5-5458C Recombinant Chicken MAP2K5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAP2K5 Related Research Area

MAP2K5 involved in several pathways and played different roles in them. We selected most pathways MAP2K5 participated on our site, such as MAPK signaling pathway, Gap junction, Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayFGF13A;MAP3K14;HSPA1B;MEF2CA;TAOK3;RPS6KA4;MAP3K6;PDGFB;RAC1B
Gap junctionTUBB6;GNA15.1;PDGFA;MAP3K2;TUBA3E;MAPK1;SOS1;TUBA1C;SRC
Neurotrophin signaling pathwayIRAK2;SHC3;IRAK1;RPS6KA3;NFKBIA;ARHGDIB;NFKB1;ARHGDIG;SH2B2
Oxytocin signaling pathwayOXTR;PRKAB2;PRKAG1;MYLK3;PRKCG;PPP1CB;RYR3;PLCB1;PPP1CA

MAP2K5 has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K5 itself. We selected most functions MAP2K5 had, and list some proteins which have the same functions with MAP2K5. You can find most of the proteins on our site.

Function Related Protein
ATP bindingBCS1L;NETO2;ATP2B2;UBE2Q2;NME2B.2;DGKG;DNAH5;HK1;HSPH1
metal ion bindingCFI;ZBTB22;Scd2;ACSM4;PPP4CA;HRG;ACO1;TATDN1;ADCY3
protein bindingGOLGA2;HENMT1;FBXL8;BCOR;DAB1;ERBB3;RHO;HARS2;STMN1
protein kinase activityMAP3K3;ABL2;PKN1B;CDKL3;AKT1;DYRK1B;ADRBK2;NLK;MAPK14B
protein serine/threonine kinase activitySTRC;SGK2B;CSNK1A1L;PRKCBA;PRKCQ;RIOK1;CSNK1E;PAK4;LIMK2
protein tyrosine kinase activityAatk;NEK1;SHC1;MAP2K4;MAP2K3;ABL2;DYRK2;DSTYK;IGF1R

MAP2K5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K5.

MAP3K3; MAPK7; HSP90AB1; GSK3B; GRB2; SIRT3; ESRRA; XRCC6; RPL28; YWHAZ; ASRGL1; LNX2; MAP3K2; CDC42BPB

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