MAP3K14

  • Official Full Name

    mitogen-activated protein kinase kinase kinase 14

  • Overview

    This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

  • Synonyms

    MAP3K14;mitogen-activated protein kinase kinase kinase 14;FTDCR1B;HS;HSNIK;NIK;serine/threonine protein kinase;NF-kappa-beta-inducing kinase;serine/threonine protein-kinase;serine/threonine-protein kinase NIK

Recombinant Proteins

  • Human
  • Chicken
  • Rhesus macaque
  • E.coli
  • Insect Cells
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • His
  • GST
  • Non
  • Avi
  • Fc
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
MAP3K14-2677H Recombinant Human MAP3K14 protein, His-tagged E.coli Human His 16-228 aa
MAP3K14-1065 Active Recombinant Human MAP3K14 protein, GST-tagged Insect Cells Human GST 325-end
MAP3K14-1065H Active Recombinant Human MAP3K14, GST-tagged Sf9 Cells Human GST 325-end
MAP3K14-2616C Recombinant Chicken MAP3K14 Mammalian Cells Chicken His
MAP3K14-2668R Recombinant Rhesus monkey MAP3K14 Protein, His-tagged Mammalian Cells Rhesus macaque His
MAP3K14-30381TH Recombinant Human MAP3K14 Human Non
MAP3K14-556H Recombinant Human MAP3K14, GST-tagged Sf9 Cells Human GST 381-end a.a.
MAP3K14-4507HCL Recombinant Human MAP3K14 293 Cell Lysate HEK293 Human Non
MAP3K14-01H Active Recombinant Human MAP3K14 Protein, GST&His-tagged Insect Cells Human GST&His
MAP3K14-0626H Recombinant Human MAP3K14 Protein (L318-P947), Tag Free Insect Cells Human Non L318-P947
MAP3K14-2488R Recombinant Rhesus Macaque MAP3K14 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
MAP3K14-2488R-B Recombinant Rhesus Macaque MAP3K14 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
MAP3K14-4382H Recombinant Human MAP3K14 protein, His&Myc-tagged E.coli Human His&Myc 400-655aa
MAP3K14-814H Recombinant Human MAP3K14 protein, His-tagged E.coli Human His 401-707 aa
MAP3K14-894H Active Recombinant Human MAP3K14 Protein, His/GST-tagged Insect Cells Human GST&His Full L. 1-947 a.a.

    Involved Pathway

    MAP3K14 involved in several pathways and played different roles in them. We selected most pathways MAP3K14 participated on our site, such as MAPK signaling pathway,NF-kappa B signaling pathway,Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TNF signaling pathway IKBKB,TRAF1,TNF,TRAF3,CASP10,SOCS3,PIK3R1,RIPK1,MLKL,VCAM1
    MAPK signaling pathway STMN1,TGFB1,CACNB3,RAC3A,DUSP16,FOS,NTF4,PRKACG,TGFBR1A,RASGRF2B
    HTLV-I infection TSPO,HLA-F,CD3E; CD3D,TGFB2,IL2RA,NFATC2,TGFBR1,EGR1,SLC2A1,SLC25A6
    NF-kappa B signaling pathway GM10591,BCL2L1,CFLAR,CXCL2,ATM,RELB,DDX58,TRAF3,LTB,IRAK4
    Osteoclast differentiation PPP3CC,LILRA2,cgr2b,PIK3CA,MAPK12,PIK3R3,STAT1,PPP3R1,SIRP-BETA,RELB
    ne network for IgA production PIGR,ITGB7,HLA-DRB3,BLB2,CXCR4A,TNFRSF17,IL15RA,BLA,MHC2DCB,CD40
    T cell receptor signaling pathway CD4,SHB,PIK3CA,LCP2,FOS,CBLB,CBLC,CARD11,VAV3,NCK1
    Apoptosis TNFRSF10B,PRKAR1B,IL1RAP,IL3,MYC,SATB1,BCAP31,TNFRSF10D,PRKACBB,NMT1
    Intestinal i TNFRSF17,CD80,MHC2DAB,MADCAM1,IL4,CXCL12B,IL5,BLB1,AICDA,HLA-DOB

    Protein Function

    MAP3K14 has several biochemical functions, for example, ATP binding,MAP kinase kinase activity,MAP kinase kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K14 itself. We selected most functions MAP3K14 had, and list some proteins which have the same functions with MAP3K14. You can find most of the proteins on our site.

    Function Related Protein
    protein kinase activity CAMK2B1,PDPK1A,MAP3K3,MAP3K1,PRKCHA,TNNI3K,CASKA,PTK2BB,STK4,RASSF2
    NF-kappaB-inducing kinase activity ALPK2,IRAK1,IKBKE,RIPK3,ALK,PPP4C
    protein binding C2orf88,TMEM183A,PAN3,ERCC2,NPPA,SSNA1,FAM119A,KCNA3,EPS15,CLOCK
    protein serine/threonine kinase activity PHKG1B,MAPKAPK5,DCAMKL2,NEK7,DAPK2,CAMK2A,AURKB,PRKCD,STK31,MAPK14A
    ATP binding ASCC3,FES,ACTR3B,MYO1H,ADCY1,FARSB,PRKACAA,BMPR2,PKDCC,MYHZ1.1
    MAP kinase kinase activity MAPKAPK5,MAP2K7,ALPK2,MAP2K2A,MAP3K20,MAP2K2,MAP2K2B,MAP3K9,SBK3,MAP2K6
    MAP kinase kinase kinase activity BRAF,ALPK2,MAP3K6,TAOK3,MAP3K5,MAP3K8,YSK4,MAP3K2,MAP3K4,MAP3K1

    Interacting Protein

    MAP3K14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K14.

    CHUK;IKBKB;ALPL;HSP90AB1;CDC37;TRAF6

    MAP3K14 Related Signal Pathway

    Resources

    Research Area

    MAP3K
    Post-translational Modification of NFkB/IkB

    References

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