MAP3K14

  • Official Full Name

    mitogen-activated protein kinase kinase kinase 14

  • Overview

    This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
  • Synonyms

    MAP3K14; mitogen-activated protein kinase kinase kinase 14; FTDCR1B; HS; HSNIK; NIK; serine/threonine protein kinase; NF-kappa-beta-inducing kinase; serine/threonine protein-kinase; serine/threonine-protein kinase NIK;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Insect
  • Insect cell
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • Strep
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP3K14-1065H Active Recombinant Human MAP3K14, GST-tagged Sf9 Insect Cell GST 325-end
Human MAP3K14-1065 Active Recombinant Human MAP3K14 protein, GST-tagged Insect Cell GST 325-end
Human MAP3K14-30381TH Recombinant Human MAP3K14 N/A
Human MAP3K14-556H Recombinant Human MAP3K14, GST-tagged Sf9 Insect Cell GST
Human MAP3K14-4507HCL Recombinant Human MAP3K14 293 Cell Lysate HEK293 N/A
Human MAP3K14-0626H Recombinant Human MAP3K14 Protein (L318-P947), Tag Free Insect Cell No tag L318-P947
Human MAP3K14-894H Active Recombinant Human MAP3K14 Protein, His/GST-tagged Insect cell His&GST
Human MAP3K14-01H Active Recombinant Human MAP3K14 Protein, GST&His-tagged Insect GST-His
Human MAP3K14-814H Recombinant Human MAP3K14 protein, His-tagged E.coli His 401-707 aa
Human MAP3K14-0627H Recombinant Human MAP3K14 Protein (L318-P947), His/Strep tagged Insect Cell His/Strep L318-P947
Human MAP3K14-4382H Recombinant Human MAP3K14 protein, His&Myc-tagged E.coli His&Myc 400-655aa
Human MAP3K14-2677H Recombinant Human MAP3K14 protein, His-tagged E.coli His 16-228 aa
Rhesus Macaque MAP3K14-2668R Recombinant Rhesus monkey MAP3K14 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MAP3K14-2488R Recombinant Rhesus Macaque MAP3K14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MAP3K14-2488R-B Recombinant Rhesus Macaque MAP3K14 Protein Pre-coupled Magnetic Beads HEK293
Chicken MAP3K14-2616C Recombinant Chicken MAP3K14 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • MAP3K14 Related Signal Pathway

MAP3K14 involved in several pathways and played different roles in them. We selected most pathways MAP3K14 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayFGF19;TGFBR1;AKT3A;PRKCBA;KRAS;PPP3CB;CDC42L;RAP1A;CACNA1G
NF-kappa B signaling pathwayIL-8;DDX58;CXCL2;PIDD1;BIRC2;TAB2;PTGS2;TICAM2;LTA
ApoptosisDIABLOB;IRF2;CAPN1A;PIK3CA;HIST1H1A;NGF;TNFRSF10C;CASP7;YWHAQ
Osteoclast differentiationTNFSF11;FCGR3B;FCGR1A;TNFRSF1A;cgr2b;IL1A;NFKB2;LILRB3;FCGR3
T cell receptor signaling pathwayPTPRC;GRAP2;OXSR1A;PAK6;VAV2;IFNG;MAP2K7;VAV3;DBNLB
TNF signaling pathwayMAPK13;DNM1L;CCL5;PIK3CD;SOCS3;MAPK1;MAP2K3;TNFAIP3;CASP10
Intestinal iH2-AB1;BMA2;HLA-DRB3;H2-AA;LTBR;Il2;CD86;CXCL12;CCL25
ne network for IgA productionCXCR4A;HLA-DPA1;CCL25;BMA2;MHC2A;MHC2DAB;CXCL12B;IL6;CD40LG
Epithelial cell signaling in Helicobacter pylori infectionATP6V1B2;ATP6V1G3;ATP6V0B;ATP6V1E2;NFKBIA;LYN;ATP6V0D1;GIT1;JAM2
HTLV-I infectionAPC;ETS1;RB1;WNT4;PTTG1;LCK;SMAD4;Pdgfa&Pdgfb;STAT5A
Epstein-Barr virus infectionTBPL1;HLA-G;PSMD7;PLCG1;NCOR2;CD19;POLR2J;PSMD8;POLR2E

MAP3K14 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, MAP kinase kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K14 itself. We selected most functions MAP3K14 had, and list some proteins which have the same functions with MAP3K14. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP4A;ATP2A1;EPHB6;ABCG2B;UBE2G1A;YARS;MYO1A;UBE2B;NARS2
MAP kinase kinase activityALPK2;SBK3;LRRK2;MAPK14;MAPK10;MAP2K1;MAP2K2;MAP3K9;MAP2K7
MAP kinase kinase kinase activityTAOK1;MAP3K14;MAP3K15;MAP3K6;MAP3K2;TAOK3;ALPK2;MAP3K8;MAP3K13
NF-kappaB-inducing kinase activityALPK2;ALK;IKBKE;MAP3K14;IRAK1;RIPK3;PPP4C
protein bindingRFX3;PYGO1;PARD6B;KCNH2;FGF10;HESX1;AP2B1;SAP30L;NOS2
protein kinase activityDAPK2A;LIMK1;PLK5;PDK1;VSIG8B;CSNK1G2B;RPS6KAL;TSSK1;PDK3
protein serine/threonine kinase activityDSTYK;RAF1B;CSNK1G2;NEK6;CDC42BPG;MAPK12;CSNK1DA;RIPK4;PRKACBB

MAP3K14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K14.

CHUK; IKBKB; ALPL; HSP90AB1; CDC37; TRAF6

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