MAP3K14

  • Official Full Name

    mitogen-activated protein kinase kinase kinase 14

  • Overview

    This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

  • Synonyms

    MAP3K14;mitogen-activated protein kinase kinase kinase 14;FTDCR1B;HS;HSNIK;NIK;serine/threonine protein kinase;NF-kappa-beta-inducing kinase;serine/threonine protein-kinase;serine/threonine-protein kinase NIK

Recombinant Proteins

  • Human
  • Chicken
  • Rhesus macaque
  • E.coli
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • Insect Cells
  • His
  • GST
  • Non
  • Avi
  • Fc
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
MAP3K14-2677H Recombinant Human MAP3K14 protein, His-tagged E.coli Human His 16-228 aa
MAP3K14-1065H Active Recombinant Human MAP3K14, GST-tagged Sf9 Cells Human GST 325-end
MAP3K14-2616C Recombinant Chicken MAP3K14 Mammalian Cells Chicken His
MAP3K14-2668R Recombinant Rhesus monkey MAP3K14 Protein, His-tagged Mammalian Cells Rhesus macaque His
MAP3K14-30381TH Recombinant Human MAP3K14 Human Non
MAP3K14-556H Recombinant Human MAP3K14, GST-tagged Sf9 Cells Human GST 381-end a.a.
MAP3K14-4507HCL Recombinant Human MAP3K14 293 Cell Lysate HEK293 Human Non
MAP3K14-01H Active Recombinant Human MAP3K14 Protein, GST&His-tagged Insect Cells Human GST&His
MAP3K14-0626H Recombinant Human MAP3K14 Protein (L318-P947), Tag Free Insect Cells Human Non L318-P947
MAP3K14-2488R Recombinant Rhesus Macaque MAP3K14 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
MAP3K14-2488R-B Recombinant Rhesus Macaque MAP3K14 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
MAP3K14-4382H Recombinant Human MAP3K14 protein, His&Myc-tagged E.coli Human His&Myc 400-655aa
MAP3K14-814H Recombinant Human MAP3K14 protein, His-tagged E.coli Human His 401-707 aa
MAP3K14-894H Active Recombinant Human MAP3K14 Protein, His/GST-tagged Insect Cells Human GST&His Full L. 1-947 a.a.

    Involved Pathway

    MAP3K14 involved in several pathways and played different roles in them. We selected most pathways MAP3K14 participated on our site, such as MAPK signaling pathway,NF-kappa B signaling pathway,Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    T cell receptor signaling pathway PAK3,PIK3R3,VAV2,PPP3R1,CABIN1,PAK7,SOS1,PPP3CB,IKBKG,AKT2
    Apoptosis IRAK2,NFKBIAA,PRKAR2AA,BID,PPP3CB,CASP6L1,DIABLOB,BCL2A,AIFM1,STK24A
    Osteoclast differentiation TRAF2,FCGR1,PIK3R2,MAPK8,IKBKB,GAB2,CALCR,STAT2,PPP3CA,LILRA4
    TNF signaling pathway MMP14,MAP2K4,PIK3R3,Casp3,MAP3K7IP3,RIPK1,IL1B,PIK3R5,ICAM1,MAPK10
    HTLV-I infection WNT16,IL6,PDGFRB,VAC14,HLA-DPA1,APC,WNT2,EP300,FOSL1,TBPL2
    ne network for IgA production PIGR,HLA-DMA,CD40,ICOSLG,HLA-DQA1,CCL28,HLA-DRA,ITGA4,Icosl,HLA-DRB1
    Epstein-Barr virus infection TRAF3,POLR2F,NFKBIB,POLR2G,HDAC4,IKBKG,IRAK1,MAPK9,MAPK8,CD19
    Epithelial cell signaling in Helicobacter pylori infection PLCG2,JAM3,ATP6V1G2,SRC,MET,ATP6V0C,ATP6V0B,TJP1,CXCR1,IKBKB
    Intestinal i Icosl,ICOS,CXCR4A,CD40LG,CCL27B,HLA-DRB3,CCL25B,IL15RA,MHC2DEB,IL-15RA

    Protein Function

    MAP3K14 has several biochemical functions, for example, ATP binding,MAP kinase kinase activity,MAP kinase kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K14 itself. We selected most functions MAP3K14 had, and list some proteins which have the same functions with MAP3K14. You can find most of the proteins on our site.

    Function Related Protein
    NF-kappaB-inducing kinase activity IRAK1,IKBKE,ALPK2,RIPK3,PPP4C,ALK
    MAP kinase kinase kinase activity BRAF,ZAK,STK4,MAP3K5,TAOK2,MAP3K4,RAF1,MAP3K2,MAP3K8,TAOK1
    protein binding KLF13,TCEA1,SNX27,BNIP2,RNF24,SYT6,LOXL2,PRPS2,THOP1,RFWD2
    protein kinase activity CLK2B,EK1,CSNK1G2A,PRPF4BB,CAMKK1A,NRBP2,GUCY2F,CAMKK1B,GRK1A,PHKG1B
    MAP kinase kinase activity MAP2K7,SBK3,MAPKAPK5,MAPK10,MAP3K20,MAP2K3,MAP2K6,MAP2K2A,MAP2K2,MAP2K2B
    ATP binding TBCK,CAMK2D,KIF5B,MAPK8A,P2RY4,PGS1,ATP1A1A.2,CLK3,ATP1A3B,TRPM6
    protein serine/threonine kinase activity Aatk,NUAK2,EIF2AK4,MAPK11,TAOK3,STK11,BMPR1A,MAP4K3,PAK7,MINK1

    Interacting Protein

    MAP3K14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K14.

    CHUK;IKBKB;ALPL;HSP90AB1;CDC37;TRAF6

    MAP3K14 Related Signal Pathway

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