MAP3K14 Protein

MAP3K14

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MAP3K14

Official Full Name mitogen-activated protein kinase kinase kinase 14
Background This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
Synonyms MAP3K14; mitogen-activated protein kinase kinase kinase 14; FTDCR1B; HS; HSNIK; NIK; serine/threonine protein kinase; NF-kappa-beta-inducing kinase; serine/threonine protein-kinase; serine/threonine-protein kinase NIK
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Insect
    • Insect cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • GST-His
    • His
    • His&GST
    • His&Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP3K14-2677H Recombinant Human MAP3K14 protein, His-tagged E.coli His
    Human MAP3K14-4382H Recombinant Human MAP3K14 protein, His&Myc-tagged E.coli His&Myc
    Human MAP3K14-814H Recombinant Human MAP3K14 protein, His-tagged E. coli His
    Human MAP3K14-01H Recombinant Human MAP3K14 Protein, GST&His-tagged Insect GST-His
    Human MAP3K14-1065 Recombinant Human MAP3K14 protein, GST-tagged Insect Cell GST
    Human MAP3K14-1065H Recombinant Human MAP3K14, GST-tagged Sf9 Insect Cell GST
    Human MAP3K14-30381TH Recombinant Human MAP3K14 N/A
    Human MAP3K14-4507HCL Recombinant Human MAP3K14 293 Cell Lysate HEK293 N/A
    Human MAP3K14-556H Recombinant Human MAP3K14, GST-tagged Sf9 Insect Cell GST
    Human MAP3K14-894H Recombinant Human MAP3K14 Protein, His/GST-tagged Insect cell His&GST
    Rhesus Macaque MAP3K14-2668R Recombinant Rhesus monkey MAP3K14 Protein, His-tagged Mammalian Cell His
    Chicken MAP3K14-2616C Recombinant Chicken MAP3K14 Mammalian Cell His

    MAP3K14 involved in several pathways and played different roles in them. We selected most pathways MAP3K14 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MEF2CA; PRKACBA; MAPKAPK3; RAC2; FGF9; ELK1; RAC1B; PPP3R1; CDC42L; PPM1NB
    NF-kappa B signaling pathway TNF; TRADD; TICAM2; ATM; GADD45B; XIAP; TRAF6; TRAF1; TLR4; MAP3K14
    Apoptosis PPP3R1B; GZMF; PPP3CB; AKT2; FASLG; DIABLO; DBNLA; PRKACBA; HIST1H1A; BIRC5A
    Osteoclast differentiation MAP2K1; TAB2; IFNGR1; FCGR3A; CAMK4; IFNAR2; NFKBIA; PPP3CB; MAPK13; TGFB1
    T cell receptor signaling pathway CD4; CARD11; RAF1; IKBKB; EVLB; IL5; CD3E; AKT2; PAK3; CABIN1
    TNF signaling pathway CXCL2; AKT1; CCL2; CXCL1; MAPK3; CXCL10; MAP3K7IP3; RIPK1; MAP2K6; CASP7
    Intestinal i PIGR; HLA-DMB; CCL25; IL6; IL15; HLA-DOB; MHC2A; AICDA; HLA-DRB1; CCR10
    ne network for IgA production CD40LG; HLA-DRB1; H2-AA; BLB1; HLA-DRB3; HLA-DRB4; TGFB1A; HLA-DOB; CD28; TGFB1
    Epithelial cell signaling in Helicobacter pylori infection PAK1; IKBKG; LYN; TJP1; ATP6V1A; ATP6V1D; MAP2K4; JAM3; ATP6V0A4; RELA
    HTLV-I infection DLG1; CALR; WNT9B; H2-AA; HLA-DRB5; IL2RA; APC2; PIK3CA; WNT2B; TGFBR2
    Epstein-Barr virus infection PLCG1; PTMA; POLR2A; EIF2AK4; PSMD13; PIK3CD; PSMC6; LYN; PSMC3; POLR2C

    MAP3K14 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, MAP kinase kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K14 itself. We selected most functions MAP3K14 had, and list some proteins which have the same functions with MAP3K14. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding OBSCN; MVK; RNASEL; CERK; CCT6A; MAP3K15; KSR1; PRKCBA; ITPKB; ACTBL2
    MAP kinase kinase activity MAP3K9; MAP2K7; MAP3K20; MAP2K2; MAP3K14; ALPK2; SBK3; MAP2K3; MAP2K2B; MAPK10
    MAP kinase kinase kinase activity MAP3K8; MAP3K6; MOS; MAP3K1; MAP3K2; RAF1; MAP3K3; MAP3K13; ALPK2; ZAK
    NF-kappaB-inducing kinase activity RIPK3; ALPK2; IRAK1; PPP4C; MAP3K14; ALK; IKBKE
    protein binding METAP2; SERPINF2; XRCC5; CLC; KAT8; SIRT6; HTR6; KCTD9; PAICS; SMPDL3A
    protein kinase activity GSK3AB; EPHA4B; PKDCCA; PAK2A; DCKL1B; PRPF4B; TNK2B; CDK7; PRKAB1; PTK7A
    protein serine/threonine kinase activity CSNK1G3; AKT1; MAP2K5; CLK1; MAPKAPK5; SRPK2; FAM20C; SGK2B; SLC14A2; RPS6KB2

    MAP3K14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K14.

    CHUK; IKBKB; ALPL; HSP90AB1; CDC37; TRAF6

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