Recombinant Human MAP3K14, GST-tagged
Cat.No. : | MAP3K14-556H |
Product Overview : | Recombinant Human MAP3K14 (a.a. 381-end) with N-terminal GST tag expressed in aBaculovirus infected Sf9 cellexpression system. MW = 96 kDa. |
- Specification
- Gene Information
- Related Products
- Download
Cat. No. : | MAP3K14-556H |
Description : | Mitogen-activated protein kinase kinase kinase 14 is an enzyme that in humans is encoded by the MAP3K14 gene. This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. |
Source : | Baculovirus infected Sf9 cell. |
Application : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Purity : | >90%. |
Formulated In : | 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT. |
Specific Activity : | 20 nM NIK yields 20% conversion of 1 uM [32P]ATP using MBP as substrate. Reaction condition: 10 mM HEPES, pH 7.4, 5 mM MgCl2, 10 μM MnCl2, 1 mM DTT, 3 μM Na-orthovanadate, 1 μM ATP, and MBP as substrate at room temperature for 2 hrs. |
Stability : | >6 months at -80°C. |
Protein length : | 381-end a.a. |
Gene Name | MAP3K14 mitogen-activated protein kinase kinase kinase 14 [ Homo sapiens ] |
Synonyms | mitogen-activated protein kinase kinase kinase 14; HS; NIK; HSNIK; FTDCR1B; MAP3K14; NF-kappa-beta-inducing kinase; serine/threonine protein-kinase; serine/threonine-protein kinase NIK; EC 2.7.11.25; Serine/threonine-protein kinase NIK |
Gene ID | 9020 |
mRNA Refseq | NM_003954.2 |
Protein Refseq | NP_003945.2 |
MIM | 604655 |
UniProt ID | Q99558 |
Chromosome Location | 17q21 |
Pathway | Apoptosis; Epithelial cell signaling in Helicobacter pylori infection; Intestinal immune network for IgA production; MAPK signaling pathway; T cell receptor signaling pathway |
Function | MAP kinase kinase kinase activity; ATP binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity |
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Ask a Question for All MAP3K14 Products
Required fields are marked with *
My Review for All MAP3K14 Products
Required fields are marked with *
0
Inquiry Basket