|Official Full Name||Myosin regulatory light chain 2|
|Background||Myosins comprise a family of ATP-dependent motor proteins and are best known for their role in muscle contraction and their involvement in a wide range of other eukaryotic motility processes. They are responsible for actin-based motility. The term was originally used to describe a group of similar ATPases found in striated and smooth muscle cells. Following the discovery by Pollard and Korn of enzymes with myosin-like function in Acanthamoeba castellanii, a large number of divergent myosin genes have been discovered throughout eukaryotes. Thus, although myosin was originally thought to be restricted to muscle cells (hence, "myo"), there is no single "myosin" but rather a huge superfamily of genes whose protein products share the basic properties of actin binding, ATP hydrolysis (ATPase enzyme activity), and force transduction. Virtually all eukaryotic cells contain myosin isoforms. Some isoforms have specialized functions in certain cell types (such as muscle), while other isoforms are ubiquitous. The structure and function of myosin is strongly conserved across species, to the extent that rabbit muscle myosin II will bind to actin from an amoeba.|
|Synonyms||Myosin regulatory light chain 2; MYL2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
myl2 involved in several pathways and played different roles in them. We selected most pathways myl2 participated on our site, such as Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with myl2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cardiac muscle contraction||TNNC1A; TPM3; MYH15; UQCRFS1; UQCR10; TMEM8C; COX5AA; CACNG2; ATP1B1; CACNG7A|
|Adrenergic signaling in cardiomyocytes||TNNI3; MYL3; ATP1A3B; CACNA1C; TNNC1; PIK3R2; PPP1CBL; TPM4B; TPM4A; CACNA1DA|
|Focal adhesion||ACTN3B; COL6A3; MAPK3; MYLPFB; COL6A4; SEPP1; PPP1CAA; PRKCA; CCND3; BAD|
|Tight junction||CLDN16; CLDNA; CLDNF; MAGI1; CLDNK; CLDN4; GNAI2A; MYL10; MLLT4; PPP2CB|
|Leukocyte transendothelial migration||Itgam&Itgb2; MYL9; CLDN7; PRKCB; ROCK1; PRKCA; PLCG2; EZR; VASP; VAV1|
|Regulation of actin cytoskeleton||SLC9A1; GSN; FGF10; ITGB2L; GNG12A; CYFIP2; ITGA9; ITGB1; GNA13A; CDC42L2|
|Hypertrophic cardiomyopathy (HCM)||SGCD; ATP2A2; ITGB6; ITGB3; MYL2; ITGA1; MYH7; MYBPC3; ITGB4; DMD|
|Dilated cardiomyopathy||ITGB8; ITGAV; PRKACB; SGCB; TPM4; TNNI3; ITGA1; MYL2; CACNG8; PRKACA|
myl2 has several biochemical functions, for example, actin monomer binding, calcium ion binding, myosin heavy chain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by myl2 itself. We selected most functions myl2 had, and list some proteins which have the same functions with myl2. You can find most of the proteins on our site.
|actin monomer binding||MTSS1; PFN1; PRKCE; LMOD3; COBLL1; KLHL8; TWF2; TMSB10; ABL2; TMSB4Y|
|calcium ion binding||S100S; EHD1; PLCB3; CAPNS1A; CALM3; NCS1B; RCVRN; MFGE8A; ANXA5B; FAT1A|
|myosin heavy chain binding||AMPD1; PDLIM2; CORO1A; MYBPC3; MYL12B; MYL9; MYL2|
|protein binding||TM4SF4; BOLA1; TFDP1; KSR1; THOC7; SYVN1; PRTFDC1; PMM1; NMU; DIAPH1|
|structural constituent of muscle||MYL5; MYL3; MYH11; NEBL; MYL2; ACTN2; TPM1; DAG1; TPM4; MYL6|
myl2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with myl2 here. Most of them are supplied by our site. Hope this information will be useful for your research of myl2.
USP6; GJB5; LRSAM1; NHP2