myl2

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myl2

Official Full Name Myosin regulatory light chain 2
Background Myosins comprise a family of ATP-dependent motor proteins and are best known for their role in muscle contraction and their involvement in a wide range of other eukaryotic motility processes. They are responsible for actin-based motility. The term was originally used to describe a group of similar ATPases found in striated and smooth muscle cells. Following the discovery by Pollard and Korn of enzymes with myosin-like function in Acanthamoeba castellanii, a large number of divergent myosin genes have been discovered throughout eukaryotes. Thus, although myosin was originally thought to be restricted to muscle cells (hence, "myo"), there is no single "myosin" but rather a huge superfamily of genes whose protein products share the basic properties of actin binding, ATP hydrolysis (ATPase enzyme activity), and force transduction. Virtually all eukaryotic cells contain myosin isoforms. Some isoforms have specialized functions in certain cell types (such as muscle), while other isoforms are ubiquitous. The structure and function of myosin is strongly conserved across species, to the extent that rabbit muscle myosin II will bind to actin from an amoeba.
Synonyms Myosin regulatory light chain 2; MYL2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Myl2-4250M Recombinant Mouse Myl2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human MYL2-235H Recombinant Human Myosin, Light Chain 2, Regulatory, Cardiac, Slow E.coli N/A
    Human MYL2-27837TH Recombinant Human MYL2, His-tagged E.coli His
    Human MYL2-28864TH Recombinant Human MYL2, His-tagged E.coli His
    Human MYL2-388H Recombinant Human Slow Cardiac Myosin Regulatory light chain 2, His-tagged E.coli His
    Human MYL2-4028HCL Recombinant Human MYL2 293 Cell Lysate HEK293 N/A
    Human MYL2-5808H Recombinant Human MYL2 Protein, GST-tagged Wheat Germ GST
    Mouse MYL2-10314M Recombinant Mouse Myl2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat MYL2-3854R Recombinant Rat MYL2 Protein Mammalian Cell His
    Chicken MYL2-4680C Recombinant Chicken MYL2 Mammalian Cell His

    myl2 involved in several pathways and played different roles in them. We selected most pathways myl2 participated on our site, such as Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with myl2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cardiac muscle contraction TNNC1A; TPM3; MYH15; UQCRFS1; UQCR10; TMEM8C; COX5AA; CACNG2; ATP1B1; CACNG7A
    Adrenergic signaling in cardiomyocytes TNNI3; MYL3; ATP1A3B; CACNA1C; TNNC1; PIK3R2; PPP1CBL; TPM4B; TPM4A; CACNA1DA
    Focal adhesion ACTN3B; COL6A3; MAPK3; MYLPFB; COL6A4; SEPP1; PPP1CAA; PRKCA; CCND3; BAD
    Tight junction CLDN16; CLDNA; CLDNF; MAGI1; CLDNK; CLDN4; GNAI2A; MYL10; MLLT4; PPP2CB
    Leukocyte transendothelial migration Itgam&Itgb2; MYL9; CLDN7; PRKCB; ROCK1; PRKCA; PLCG2; EZR; VASP; VAV1
    Regulation of actin cytoskeleton SLC9A1; GSN; FGF10; ITGB2L; GNG12A; CYFIP2; ITGA9; ITGB1; GNA13A; CDC42L2
    Hypertrophic cardiomyopathy (HCM) SGCD; ATP2A2; ITGB6; ITGB3; MYL2; ITGA1; MYH7; MYBPC3; ITGB4; DMD
    Dilated cardiomyopathy ITGB8; ITGAV; PRKACB; SGCB; TPM4; TNNI3; ITGA1; MYL2; CACNG8; PRKACA

    myl2 has several biochemical functions, for example, actin monomer binding, calcium ion binding, myosin heavy chain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by myl2 itself. We selected most functions myl2 had, and list some proteins which have the same functions with myl2. You can find most of the proteins on our site.

    Function Related Protein
    actin monomer binding MTSS1; PFN1; PRKCE; LMOD3; COBLL1; KLHL8; TWF2; TMSB10; ABL2; TMSB4Y
    calcium ion binding S100S; EHD1; PLCB3; CAPNS1A; CALM3; NCS1B; RCVRN; MFGE8A; ANXA5B; FAT1A
    myosin heavy chain binding AMPD1; PDLIM2; CORO1A; MYBPC3; MYL12B; MYL9; MYL2
    protein binding TM4SF4; BOLA1; TFDP1; KSR1; THOC7; SYVN1; PRTFDC1; PMM1; NMU; DIAPH1
    structural constituent of muscle MYL5; MYL3; MYH11; NEBL; MYL2; ACTN2; TPM1; DAG1; TPM4; MYL6

    myl2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with myl2 here. Most of them are supplied by our site. Hope this information will be useful for your research of myl2.

    USP6; GJB5; LRSAM1; NHP2

    Colson, BA; Petersen, KJ; et al. The myosin super-relaxed state is disrupted by estradiol deficiency. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 456:151-155(2015).
    Wang, L; Muthu, P; et al. Diversity and similarity of motor function and cross-bridge kinetics in papillary muscles of transgenic mice carrying myosin regulatory light chain mutations D166V and R58Q. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 62:153-163(2013).

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