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NOX4

Official Full Name

NADPH oxidase 4
Overview

This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
Synonyms

NOX4; NADPH oxidase 4; KOX; KOX 1; kidney oxidase-1; renal NAD(P)H-oxidase; kidney superoxide-producing NADPH oxidase; KOX-1; RENOX;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Homo sapiens (Human)
Human
Mouse
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Rat
Rattus norvegicus (Rat)
Sumatran orangutan

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
In vitro E. coli expression system
In vitro E.coli expression system
Mammalian Cell
Wheat Germ
Yeast

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NOX4-29711TH	Recombinant Human NOX4	Wheat Germ	Non	100 amino acids	Inquiry
Human	NOX4-1977H	Recombinant Human NOX4 protein, His-tagged	E.coli	His	Asp220~Asp392	Inquiry
Human	NOX4-1336H	Recombinant Human NOX4, GST-tagged	E.coli	GST	224-578aa	$319 / 25μg
Human	NOX4-22H	Recombinant Human NOX4 Protein	Wheat Germ	Non		Inquiry
Human	NOX4-2499H	Recombinant Human NOX4 Protein, His-tagged	E.coli	His	Leu446-Ser578	Inquiry
Human	NOX4-298H	Recombinant Human NOX4 protein, His-tagged(VLPs)	HEK293	His	1-578aa	Inquiry
Human	NOX4-6008H	Recombinant Human NOX4 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	NOX4-2948H	Recombinant Human NOX4 Transmembrane protein, His-tagged	In vitro E.coli expression system	His	210-424aa	Inquiry
Human	NOX4-2783H	Recombinant Human NOX4 Protein (Gly210-Glu424), His tagged	E.coli	His	Gly210-Glu424	Inquiry
Human	NOX4-3282H	Recombinant Human NOX4 protein, His-tagged	E.coli	His	210-424aa	Inquiry
Human	NOX4-1539HF	Recombinant Full Length Human NOX4 Protein	In Vitro Cell Free System		578 amino acids	Inquiry
Mouse	Nox4-1840M	Recombinant Mouse Nox4 Protein, His-tagged	E.coli	His	Gly210-Ser578	Inquiry
Rat	NOX4-4032R	Recombinant Rat NOX4 Protein	Mammalian Cell	His		Inquiry
Rat	NOX4-3691R	Recombinant Rat NOX4 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	NOX4-2200R	Recombinant Rat NOX4 Protein (210-424 aa), His-B2M-tagged	E.coli	His&B2M	210-424 aa	Inquiry
Rat	NOX4-3691R-B	Recombinant Rat NOX4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	NOX4-1475R	Recombinant Rat NOX4 Protein (210-424 aa), His-tagged	Yeast	His	210-424 aa	Inquiry
Homo sapiens (Human)	RFL28341HF	Recombinant Full Length Human Nadph Oxidase 4(Nox4) Protein, His-Tagged	E.coli expression system	His	Full Length (1-578aa)	Inquiry
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	RFL35916PF	Recombinant Full Length Pongo Abelii Nadph Oxidase 4(Nox4) Protein, His-Tagged	E.coli expression system	His	Full Length (1-578aa)	Inquiry
Rattus norvegicus (Rat)	RFL16211RF	Recombinant Full Length Rat Nadph Oxidase 4(Nox4) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (210-424)	Inquiry
Sumatran orangutan	NOX4-1328S	Recombinant Sumatran orangutan NOX4 Full Length Transmembrane protein, His-tagged	In vitro E. coli expression system	His	1-578aa	Inquiry
Chicken	NOX4-3740C	Recombinant Chicken NOX4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

NOX4 involved in several pathways and played different roles in them. We selected most pathways NOX4 participated on our site, such as Oxidative Stress, Signaling events mediated by PTP1B, Spinal Cord Injury, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Oxidative Stress	NOX4;TXN2;NFIX;TXNRD2;JUNBA;NQO1
Signaling events mediated by PTP1B	NOX4;CSN2;DOK1;YBX1
Spinal Cord Injury	GAP43;LGALS3;AIF1;GDNF;OMG;RTN4;RGMA;LILRB3;TNFSF13B

NOX4 has several biochemical functions, for example, NAD(P)H oxidase activity, electron carrier activity, flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOX4 itself. We selected most functions NOX4 had, and list some proteins which have the same functions with NOX4. You can find most of the proteins on our site.

Function	Related Protein
NAD(P)H oxidase activity	NOX4;DERL3;CYB5R4;AIFM1;KMO;DUOX2
electron carrier activity	COX7A2A;AOX4;NDUFA12;ADH5;GRX2;QDPR;COX7A1;ACAD11;UQCR11
flavin adenine dinucleotide binding	GULO;GCDHB;NOS1;NOS2;POR;AIFM3;DHCR24;ACADVL;DMGDH
heme binding	CYP27B1;CYP2K18;EIF2AK1;SDHDA;DUOX2;FA2H;CYP4F11;PGRMC1;HBA-X
modified amino acid binding	CBS;DPEP1;NOX4;CPS1;MTHFR;MUT
nucleotide binding	PPIL4;CDC42L2;ATP9A;SRSF9;CLCN4-2;Akap17b;CPEB1A;RBM17;PET112L
oxygen sensor activity	HIF1AN;EGLN2;NOX4
superoxide-generating NADPH oxidase activity	CYBB;NOX5;NCF1;NOX4;NOX3;SH3PXD2AA;NOX1;PAX2

NOX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOX4.

Research Area

Inflammatory Mediators

ROS and Stress Resistance

Zhao, WW; Ma, GX; et al. Lipopolysaccharide induced LOX-1 expression via TLR4/MyD88/ROS activated p38MAPK-NF-kappa B pathway. VASCULAR PHARMACOLOGY 63:162-172(2014).

Nayernia, Z; Jaquet, V; et al. New Insights on NOX Enzymes in the Central Nervous System. ANTIOXIDANTS & REDOX SIGNALING 20:2815-2837(2014).