NOX4

  • Official Full Name

    NADPH oxidase 4

  • Overview

    This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
  • Synonyms

    NOX4; NADPH oxidase 4; KOX; KOX 1; kidney oxidase-1; renal NAD(P)H-oxidase; kidney superoxide-producing NADPH oxidase; KOX-1; RENOX;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rat
  • Rattus norvegicus (Rat)
  • Sumatran orangutan
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • In vitro E.coli expression system
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|B2M
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NOX4-29711TH Recombinant Human NOX4 Wheat Germ N/A
Human NOX4-1977H Recombinant Human NOX4 protein, His-tagged E.coli His
Human NOX4-1336H Recombinant Human NOX4, GST-tagged E.coli GST
Human NOX4-22H Recombinant Human NOX4 Protein Wheat Germ N/A
Human NOX4-2499H Recombinant Human NOX4 Protein, His-tagged E.coli N-His
Human NOX4-298H Recombinant Human NOX4 protein, His-tagged(VLPs) HEK293 His
Human NOX4-6008H Recombinant Human NOX4 Protein, GST-tagged Wheat Germ GST
Human NOX4-2948H Recombinant Human NOX4 Transmembrane protein, His-tagged In vitro E.coli expression system His
Human NOX4-2783H Recombinant Human NOX4 Protein (Gly210-Glu424), His tagged E.coli His
Human NOX4-3282H Recombinant Human NOX4 protein, His-tagged E.coli His
Human NOX4-1539HF Recombinant Full Length Human NOX4 Protein In Vitro Cell Free System
Mouse Nox4-1840M Recombinant Mouse Nox4 Protein, His-tagged E.coli N-His
Rat NOX4-4032R Recombinant Rat NOX4 Protein Mammalian Cell His
Rat NOX4-3691R Recombinant Rat NOX4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NOX4-2200R Recombinant Rat NOX4 Protein (210-424 aa), His-B2M-tagged E.coli His/B2M
Rat NOX4-3691R-B Recombinant Rat NOX4 Protein Pre-coupled Magnetic Beads HEK293
Rat NOX4-1475R Recombinant Rat NOX4 Protein (210-424 aa), His-tagged Yeast His
Homo sapiens (Human) RFL28341HF Recombinant Full Length Human Nadph Oxidase 4(Nox4) Protein, His-Tagged E.coli expression system His
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL35916PF Recombinant Full Length Pongo Abelii Nadph Oxidase 4(Nox4) Protein, His-Tagged E.coli expression system His
Rattus norvegicus (Rat) RFL16211RF Recombinant Full Length Rat Nadph Oxidase 4(Nox4) Protein, His-Tagged E.coli expression system His
Sumatran orangutan NOX4-1328S Recombinant Sumatran orangutan NOX4 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His
Chicken NOX4-3740C Recombinant Chicken NOX4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NOX4 Related Articles
  • NOX4 Related Research Area

NOX4 involved in several pathways and played different roles in them. We selected most pathways NOX4 participated on our site, such as Oxidative Stress, Signaling events mediated by PTP1B, Spinal Cord Injury, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative StressNFIX;TXNRD2;JUNBA;NOX4;NQO1;TXN2
Signaling events mediated by PTP1BYBX1;CSN2;DOK1;NOX4
Spinal Cord InjuryRGMA;MBP;RTN4;RTN4R;KLK8;GAP43;AIF1;LGALS3;NOX4

NOX4 has several biochemical functions, for example, NAD(P)H oxidase activity, electron carrier activity, flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOX4 itself. We selected most functions NOX4 had, and list some proteins which have the same functions with NOX4. You can find most of the proteins on our site.

Function Related Protein
NAD(P)H oxidase activityAIFM1;DUOX2;NOX4;KMO;CYB5R4;DERL3
electron carrier activityGSR;AKR1C4;FDX1L;ACADS;ACOXL;SDHC;ADH5;NDUFS2;ACAD8
flavin adenine dinucleotide bindingACADS;NOX5;DLD;SDHA;AIFM3;ACADM;GULO;ACOX1;FMO2
heme bindingHBBE2;CYP2C9;CYP2P9;CYP2AA4;CYP51;CYP19A1;HBE;CAT;HRG
modified amino acid bindingMTHFR;DPEP1;NOX4;CPS1;MUT;CBS
nucleotide bindingATP2B2;BOLL;ATP2B1B;UBE2D1A;RAB12;ADCY1B;SAFB;SRPK1B;RHOT1A
oxygen sensor activityNOX4;HIF1AN;EGLN2
superoxide-generating NADPH oxidase activityNCF1;NOX3;NOX5;NOX4;SH3PXD2AA;NOX1;CYBB;PAX2

NOX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOX4.

Zhao, WW; Ma, GX; et al. Lipopolysaccharide induced LOX-1 expression via TLR4/MyD88/ROS activated p38MAPK-NF-kappa B pathway. VASCULAR PHARMACOLOGY 63:162-172(2014).
Nayernia, Z; Jaquet, V; et al. New Insights on NOX Enzymes in the Central Nervous System. ANTIOXIDANTS & REDOX SIGNALING 20:2815-2837(2014).
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