NPM1

  • Official Full Name

    nucleophosmin (nucleolar phosphoprotein B23, numatrin)
  • Overview

    This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
  • Synonyms

    NPM1;nucleophosmin (nucleolar phosphoprotein B23, numatrin);B23;NPM;nucleophosmin;nucleolar protein NO38;nucleophosmin/nucleoplasmin family, member 1

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Chicken
  • E.coli
  • HEK293
  • Mammalian Cells
  • In Vitro Cell Free System
  • Wheat Germ
  • His
  • SUMO
  • DDK
  • Myc
  • GST
  • Flag
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
NPM1-181H Recombinant Human NPM1 protein(Glu2-Leu294), His-tagged E.coli Human His Glu2-Leu294
NPM1-3805H Recombinant Human NPM1 protein(Met9-Leu158), His-tagged E.coli Human His Met9-Leu158
Npm1-1297M Recombinant Mouse Npm1 Protein, His-SUMO-tagged E.coli Mouse His&SUMO 1-292 a.a.
NPM1-134H Recombinant Human NPM1 protein, MYC/DDK-tagged HEK293 Human DDK&Myc
NPM1-135H Recombinant Human NPM1 protein, MYC/DDK-tagged HEK293 Human DDK&Myc
NPM1-1417H Recombinant Human NPM1, GST-tagged Human GST
NPM1-4046R Recombinant Rat NPM1 Protein Mammalian Cells Rat His
NPM1-4839H Recombinant Human NPM1 protein, Flag-tagged HEK293 Human Flag
NPM1-54H Recombinant Human NPM1, His-tagged E.coli Human His
NPM1-6799H Recombinant Human Nucleophosmin (nucleolar phosphoprotein B23, numatrin), His-tagged E.coli Human His
NPM1-6819C Recombinant Chicken NPM1 Mammalian Cells Chicken His
Npm1-7990M Recombinant Mouse Npm1 protein, His-tagged E.coli Mouse His Gly20~Lys154
NPM1-3737HCL Recombinant Human NPM1 293 Cell Lysate HEK293 Human Non
NPM1-3738HCL Recombinant Human NPM1 293 Cell Lysate HEK293 Human Non
NPM1-3739HCL Recombinant Human NPM1 293 Cell Lysate HEK293 Human Non
NPM1-1253H Recombinant Human NPM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
NPM1-1607H Recombinant Human NPM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
NPM1-231H Recombinant Human NPM1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
NPM1-2572H Recombinant Human NPM1 protein(21-130 aa), C-His-tagged E.coli Human His 21-130 aa
NPM1-346HF Recombinant Full Length Human NPM1 Protein In Vitro Cell Free System Human Full L. 295 amino acids
NPM1-3705R Recombinant Rat NPM1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
NPM1-3705R-B Recombinant Rat NPM1 Protein Pre-coupled Magnetic Beads HEK293 Rat
Npm1-4474M Recombinant Mouse Npm1 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
NPM1-4728H Recombinant Human NPM1 Protein (Gly20-Lys154), N-His tagged E.coli Human His Gly20-Lys154
NPM1-6037H Recombinant Human NPM1 Protein, GST-tagged Wheat Germ Human GST
NPM1-6322H Recombinant Human NPM1 protein, His-tagged E.coli Human His 1-294aa
NPM1-6628HF Recombinant Full Length Human NPM1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 294 amino acids
NPM1-7530H Recombinant Human NPM1 protein E.coli Human Non 265aa
NPM1-7985HFL Recombinant Full Length Human NPM1 protein, Flag-tagged Mammalian Cells Human Flag Full L.

    Involved Pathway

    NPM1 involved in several pathways and played different roles in them. We selected most pathways NPM1 participated on our site, such as Aurora B signaling,BARD1 signaling events,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Deposition of new CENPA-containing nucleosomes at the centromere OIP5,APITD1,CENPL,CENPC1,MIS18A,CENPH,RBBP4,CENPP,CENPN,CENPQ
    HIF-1-alpha transcription factor network EGLN3,TFF3,ADM,CP,PLIN2,NDRG1,COPS5,GATA2,ENG,CITED2
    Cell cycle ORC6,SPC24,HIST2H3C,SKA2,MCM8,FAM175A,NEK6,YWHAE2,FKBP6,DYNC1H1
    BARD1 signaling events BARD1,RBBP8,RAD50,CDK2,CSTF1
    Chromosome Maintenance DNA2,RBBP7,CENPL,CENPW,CENPC1,TERF2IP,ITGB3BP,TINF2,POT1,POT1A
    Aurora B signaling AURKC,CBX5,AURKB,SGOL1,EVI5,RACGAP1,KIF20A,NCAPH,INCENP,CDCA8
    HIV Infection APOBEC3G,AP1B1,DOCK2,CHMP4B,CHMP4C,ELL,PSIP1,PACS1,AP1S1,NMT2
    Disease PPIAL4A,SFTPC,ELL,MMADHC,MMAA,CPSF4,VPS37A,NMT1,CDK9,SYT2

    Protein Function

    NPM1 has several biochemical functions, for example, NF-kappaB binding,RNA binding,Tat protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPM1 itself. We selected most functions NPM1 had, and list some proteins which have the same functions with NPM1. You can find most of the proteins on our site.

    Function Related Protein
    ribosomal large subunit binding MALSU1,OLA1,NMD3,EIF6,RBM3,MRRF,CPEB2
    protein kinase binding B4GALT1,E2F1,CDKN2D,AGAP2,EPHA1,DCX,CYLD,FBXW5,FBXO7,PPME1
    RNA binding RBFOX1,RANBP2,EMG1,RPL27A,APOBEC1,PTBP2B,DHX36,SF3B3,RPLP2,PAPOLB
    protein kinase inhibitor activity SH3BP5,NCK1,SOCS1A,TRIB1,DUSP19,SOCS3A,SOCS3,JIP1,SH3BP5LA,SH3BP5L
    transcription coactivator activity TCF3,SUB1A,CTNNB1,GTF2F1,MED17,CCNE1,MKL1B,TADA1,HCFC1,SIX3
    unfolded protein binding AFG3L2,CLGN,AHSP,NDUFAF1,HSPA5,TOMM20,HSPA1A,CCT5,CALR3B,HSPA2
    Tat protein binding TRIM32,DLL1,ACTB,MDFIC,SMARCA4,GABARAPL1,SMARCB1
    histone binding SNCA,HIST1H4I,SIRT1,HIST1H4E,HIST1H4N,USP3,DNAJC2,UHRF1,UIMC1,DAXX
    NF-kappaB binding ANKRD42,SNAI1A,EP300,COMMD6,AP1S2,BCL10,HDAC3,FAF1,COMMD7,TAF4B

    Interacting Protein

    NPM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPM1.

    SENP3;MDM2;TP53;pre-C/C

    Resources

    Research Area

    References

    • Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).
    • Ehninger, A; Kramer, M; et al. Distribution and levels of cell surface expression of CD33 and CD123 in acute myeloid leukemia. BLOOD CANCER JOURNAL 4:-(2014).

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