NPM1
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Official Full Name
nucleophosmin (nucleolar phosphoprotein B23, numatrin) -
Overview
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009] -
Synonyms
NPM1;nucleophosmin (nucleolar phosphoprotein B23, numatrin);B23;NPM;nucleophosmin;nucleolar protein NO38;nucleophosmin/nucleoplasmin family, member 1
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- HEK293
- Mammalian Cells
- In Vitro Cell Free System
- Wheat Germ
- His
- SUMO
- DDK
- Myc
- GST
- Flag
- Non
- Avi
- Fc
Involved Pathway
NPM1 involved in several pathways and played different roles in them. We selected most pathways NPM1 participated on our site, such as Aurora B signaling,BARD1 signaling events,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Deposition of new CENPA-containing nucleosomes at the centromere | OIP5,APITD1,CENPL,CENPC1,MIS18A,CENPH,RBBP4,CENPP,CENPN,CENPQ |
| HIF-1-alpha transcription factor network | EGLN3,TFF3,ADM,CP,PLIN2,NDRG1,COPS5,GATA2,ENG,CITED2 |
| Cell cycle | ORC6,SPC24,HIST2H3C,SKA2,MCM8,FAM175A,NEK6,YWHAE2,FKBP6,DYNC1H1 |
| BARD1 signaling events | BARD1,RBBP8,RAD50,CDK2,CSTF1 |
| Chromosome Maintenance | DNA2,RBBP7,CENPL,CENPW,CENPC1,TERF2IP,ITGB3BP,TINF2,POT1,POT1A |
| Aurora B signaling | AURKC,CBX5,AURKB,SGOL1,EVI5,RACGAP1,KIF20A,NCAPH,INCENP,CDCA8 |
| HIV Infection | APOBEC3G,AP1B1,DOCK2,CHMP4B,CHMP4C,ELL,PSIP1,PACS1,AP1S1,NMT2 |
| Disease | PPIAL4A,SFTPC,ELL,MMADHC,MMAA,CPSF4,VPS37A,NMT1,CDK9,SYT2 |
Protein Function
NPM1 has several biochemical functions, for example, NF-kappaB binding,RNA binding,Tat protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPM1 itself. We selected most functions NPM1 had, and list some proteins which have the same functions with NPM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ribosomal large subunit binding | MALSU1,OLA1,NMD3,EIF6,RBM3,MRRF,CPEB2 |
| protein kinase binding | B4GALT1,E2F1,CDKN2D,AGAP2,EPHA1,DCX,CYLD,FBXW5,FBXO7,PPME1 |
| RNA binding | RBFOX1,RANBP2,EMG1,RPL27A,APOBEC1,PTBP2B,DHX36,SF3B3,RPLP2,PAPOLB |
| protein kinase inhibitor activity | SH3BP5,NCK1,SOCS1A,TRIB1,DUSP19,SOCS3A,SOCS3,JIP1,SH3BP5LA,SH3BP5L |
| transcription coactivator activity | TCF3,SUB1A,CTNNB1,GTF2F1,MED17,CCNE1,MKL1B,TADA1,HCFC1,SIX3 |
| unfolded protein binding | AFG3L2,CLGN,AHSP,NDUFAF1,HSPA5,TOMM20,HSPA1A,CCT5,CALR3B,HSPA2 |
| Tat protein binding | TRIM32,DLL1,ACTB,MDFIC,SMARCA4,GABARAPL1,SMARCB1 |
| histone binding | SNCA,HIST1H4I,SIRT1,HIST1H4E,HIST1H4N,USP3,DNAJC2,UHRF1,UIMC1,DAXX |
| NF-kappaB binding | ANKRD42,SNAI1A,EP300,COMMD6,AP1S2,BCL10,HDAC3,FAF1,COMMD7,TAF4B |
Interacting Protein
NPM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPM1.
SENP3;MDM2;TP53;pre-C/C
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References
- Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).
- Ehninger, A; Kramer, M; et al. Distribution and levels of cell surface expression of CD33 and CD123 in acute myeloid leukemia. BLOOD CANCER JOURNAL 4:-(2014).
