Recombinant Human NPM1 protein, Flag-tagged NPM1-4839H

Recombinant Human NPM1 protein, Flag-tagged

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Recombinant Human NPM1 protein, Flag-tagged

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Cat.No. : NPM1-4839H
Product Overview : Recombinant Human NPM1, transcript variant 3, fused with Flag tag was expressed in HEK293.
Description : This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : Flag
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 28.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) [ Homo sapiens ]
Official Symbol : NPM1
Synonyms : NPM1; nucleophosmin (nucleolar phosphoprotein B23, numatrin); nucleophosmin; B23; NPM; nucleolar phosphoprotein B23; nucleophosmin/nucleoplasmin family; member 1; numatrin; nucleolar protein NO38; nucleophosmin/nucleoplasmin family, member 1; MGC104254;
Gene ID : 4869
mRNA Refseq : NM_001037738
Protein Refseq : NP_001032827
MIM : 164040
UniProt ID : P06748
Chromosome Location : 5q35.1
Pathway : Aurora B signaling, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; Deposition of New CENPA-containing Nucleosomes at the Centromere, organism-specific biosystem; Disease, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem;
Function : NF-kappaB binding; NF-kappaB binding; RNA binding; Tat protein binding; histone binding; nucleic acid binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; ribosomal large subunit binding; ribosomal small subunit binding; transcription coactivator activity; unfolded protein binding; unfolded protein binding;

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