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  • Official Full Name

    phosphodiesterase 1B, calmodulin-dependent

  • Overview

    The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
  • Synonyms

    PDE1B; phosphodiesterase 1B, calmodulin-dependent; PDES1B; calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B; cam-PDE 1B; 63 kDa Cam-PDE; calmodulin-stimulated phosphodiesterase PDE1B1; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B; PDE1B1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Insect cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDE1B-442H Recombinant Human PDE1B, GST-tagged Sf9 Insect Cell GST
Human PDE1B-1599H Recombinant Human PDE1B, GST-tagged E.coli GST C-term-350aa
Human PDE1B-1164H Recombinant Human PDE1B protein, His&GST-tagged Insect Cells His/GST Met1-Asp536
Human PDE1B-29995TH Recombinant Human PDE1B N/A
Human PDE1B-627HCL Recombinant Human PDE1B cell lysate Insect Cell N/A
Human PDE1B-704HFL Recombinant Full Length Human PDE1B Protein, C-Flag-tagged Mammalian cells Flag
Human PDE1B-04H Recombinant Human PDE1B Protein, His/GST-tagged Insect Cell His/GST 1-536
Human PDE1B-745H Recombinant Human PDE1B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PDE1B-1631H-B Recombinant Human PDE1B Protein Pre-coupled Magnetic Beads HEK293
Human PDE1B-042H Recombinant Human PDE1B Protein, His/GST-tagged Insect cell His/GST 1-536
Human PDE1B-2292H Recombinant Human PDE1B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PDE1B16287H Recombinant Human PDE1B (146-502) Protein
Human PDE1B-1631H Recombinant Human PDE1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PDE1B-12548M Recombinant Mouse PDE1B Protein Mammalian Cell His
Mouse Pde1b-4743M Recombinant Mouse Pde1b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PDE1B-6583M-B Recombinant Mouse PDE1B Protein Pre-coupled Magnetic Beads HEK293
Mouse PDE1B-6583M Recombinant Mouse PDE1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PDE1B-4326R Recombinant Rat PDE1B Protein Mammalian Cell His
Rat PDE1B-3986R-B Recombinant Rat PDE1B Protein Pre-coupled Magnetic Beads HEK293
Rat PDE1B-3986R Recombinant Rat PDE1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PDE1B-3346R Recombinant Rhesus monkey PDE1B Protein, His-tagged Mammalian Cell His
Rhesus Macaque PDE1B-3164R Recombinant Rhesus Macaque PDE1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PDE1B-3164R-B Recombinant Rhesus Macaque PDE1B Protein Pre-coupled Magnetic Beads HEK293
Kit-1825 PDE1B Assay Kit N/A
Kit-1827 PDE1B TR-FRET Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PDE1B involved in several pathways and played different roles in them. We selected most pathways PDE1B participated on our site, such as Purine metabolism, Calcium signaling pathway, Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Olfactory transductionOLFR147;GUCY2E;OLFR493;OLFR10;PRKACG;PDE2A;PRKACB;RGS2;OLFR481

PDE1B has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, calcium- and calmodulin-regulated 3,5-cyclic-GMP phosphodiesterase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE1B itself. We selected most functions PDE1B had, and list some proteins which have the same functions with PDE1B. You can find most of the proteins on our site.

Function Related Protein
3,5-cyclic-AMP phosphodiesterase activityPDE4C;PDE3A;PDE8B;PDE4A;PDE7A;PDE4D;PDE7B;TDP2B;PDE1B
calcium- and calmodulin-regulated 3,5-cyclic-GMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activityUSB1;TDP2B;PDE1C;PDE1B;PDE1A

PDE1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE1B.


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