PDE1B
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Official Full Name
phosphodiesterase 1B, calmodulin-dependent
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Background
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
PDE1B; phosphodiesterase 1B, calmodulin-dependent; PDES1B; calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B; cam-PDE 1B; 63 kDa Cam-PDE; calmodulin-stimulated phosphodiesterase PDE1B1; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B; PDE1B1;
- Involved Pathway
- Protein Function
- Interacting Protein
PDE1B involved in several pathways and played different roles in them. We selected most pathways PDE1B participated on our site, such as Purine metabolism, Calcium signaling pathway, Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | PRIM2;AK2;PDE10A;POLR3K;PKM2;NT5C1BA;CANT1B;PNPT1;NME2 |
| Calcium signaling pathway | ORAI3;PLN;CAMK2G1;EDNRAA;LTB4R2;GNA11;SPHK2;CCKBR;GNA15.4 |
| Olfactory transduction | OR51B4;PDE1C;PDC;OR5H1;OR2L5;NCALD;OLFR495;GNB1;OLFR18 |
| Renin secretion | Ren1;AGTR1B;PDE1A;CALM2;AGTR1A;ITPR1;ORAI1;PPP3CB;LOC100328615 |
PDE1B has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, calcium- and calmodulin-regulated 3,5-cyclic-GMP phosphodiesterase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE1B itself. We selected most functions PDE1B had, and list some proteins which have the same functions with PDE1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3,5-cyclic-AMP phosphodiesterase activity | TDP2B;PDE8B;PDE4B;USB1;PDE7A;PDE1B;PDE8A;PDE3A;PDE4C |
| calcium- and calmodulin-regulated 3,5-cyclic-GMP phosphodiesterase activity | |
| calmodulin binding | UBR4;PHKA2;ATP2B1;REM1;AKAP5;PCP4;MKNK1;PHKG1A;EPB41 |
| calmodulin-dependent cyclic-nucleotide phosphodiesterase activity | PDE1A;USB1;PDE1B;TDP2B;PDE1C |
| metal ion binding | GUCA1G;LIG4;CHEK2;CYP2N13;GLIS1;EXT1;ZXDC;LTN1;PDE8A |
| protein binding | TM4SF4;FH;YRDC;SCARF1;KARS;CSTF1;RABIF;CDC42EP1;ATP1B1 |
PDE1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE1B.
POT1; UBE3A
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