Recombinant Human PDE1B Protein, His/GST-tagged

• Cat.No.: PDE1B-042H
• Product Overview: Recombinant N-terminal His-GST-tagged full length human PDE1B1 protein (1-536) was expressed in insect cells.

Specification

• Description: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Source: Insect cell
• Species: Human
• Tag: His&GST
• Form: Lyophilized
• Molecular Mass: 89.2 kDa
• Protein length: 1-536
• Endotoxin: <1.0 EU/ μg, determined by the LAL endotoxin assay.
• Purity: ≥94% estimated by SDS-PAGE
• Stability: ≥ 1 year
• Storage: At -80 centigrade.
• Storage Buffer: Sterile 50 mM Tris, pH 8.0, with 100 mM sodium chloride

Gene Information

• Gene Name: PDE1B phosphodiesterase 1B [ Homo sapiens (human) ]
• Official Symbol: PDE1B
• Synonyms: PDE1B; phosphodiesterase 1B; PDE1B1; PDES1B; HEL-S-79p; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; 63 kDa Cam-PDE; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; calmodulin-stimulated phosphodiesterase PDE1B1; cam-PDE 1B; epididymis secretory sperm binding protein Li 79p; phosphodiesterase 1B, calmodulin-dependent; presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B; EC 3.1.4.17
• Gene ID: 5153
• mRNA Refseq: NM_000924
• Protein Refseq: NP_000915
• MIM: 171891
• UniProt ID: Q01064