PDE4D

  • Official Full Name

    phosphodiesterase 4D, cAMP-specific

  • Overview

    This gene encodes one of four mammalian counterparts to the fruit fly dunce gene. The encoded protein has 3,5-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
  • Synonyms

    PDE4D; phosphodiesterase 4D, cAMP-specific; DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2; cAMP-specific 3,5-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Dog
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Sf9 insect cells
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDE4D-10H Active Recombinant Human PDE4D protein, GST-tagged Insect Cell GST
Human PDE4D-1601H Recombinant Human PDE4D, GST-tagged E.coli GST C-term-349aa
Human PDE4D-28756TH Recombinant Human PDE4D N/A
Human PDE4D-478H Recombinant Human PDE4D, GST-tagged, Active Sf9 Insect Cell GST
Human PDE4D-3350HCL Recombinant Human PDE4D 293 Cell Lysate HEK293 N/A
Human PDE4D-1602H Recombinant Human PDE4D protein, His-tagged E.coli His 170-518 aa
Human PDE4D-0556H Recombinant Human PDE4D Protein (T388-S715), Tag Free E.coli No tag T388-S715
Human PDE4D-303H Recombinant Human PDE4D Protein, His/GST-tagged E.coli His/GST Leu581~Thr809
Human PDE4D-0557H Recombinant Human PDE4D Protein (T388-S715), His tagged E.coli His T388-S715
Human PDE4D19751H Recombinant Human PDE4D (388-715) Protein
Human PDE4D-1687H Recombinant Human PDE4D Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Pde4d-4747M Recombinant Mouse Pde4d Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Pde4d-12R Active Recombinant Rat Pde4d Protein (2-804), N-GST tagged Sf9 insect cells N-GST 2-804
Rat PDE4D-4332R Recombinant Rat PDE4D Protein Mammalian Cell His
Rat PDE4D-3992R-B Recombinant Rat PDE4D Protein Pre-coupled Magnetic Beads HEK293
Rat PDE4D-3992R Recombinant Rat PDE4D Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Dog PDE4D-11D Active Recombinant Dog PDE4D Protein (2-679), N-GST tagged Sf9 insect cells N-GST 2-679
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PDE4D involved in several pathways and played different roles in them. We selected most pathways PDE4D participated on our site, such as Purine metabolism, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPOLR3E;CECR1;PGM2;PDE8B;GUK1;PDE5AB;AK5;ENTPD2;NME2A
cAMP signaling pathwayATP1B2;TSHR;RELA;PLD2;PDE4D;ATP1B3;NFKBIA;GIPR;NPY

PDE4D has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, ATPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4D itself. We selected most functions PDE4D had, and list some proteins which have the same functions with PDE4D. You can find most of the proteins on our site.

Function Related Protein
3,5-cyclic-AMP phosphodiesterase activityPDE8A;PDE4A;PDE4B;PDE4D;PDE1B;PDE7A;PDE8B;PDE3A;PDE7B
3,5-cyclic-nucleotide phosphodiesterase activityPDE5A;PDE6D;PDE8B;PDE3B;PDE8A;PDE5AB;PDE4D;PDE9A;PDE10A
ATPase bindingEZR;PGR;SELS;SDF2L1;SNX10;ATP6V0A4;ALDOB;ATP1B2;USP25
SH3 domain bindingPDCD6IP;SH3BGRL2;QKI2;INPPL1B;CTTNBP2;KHDRBS3;TOM1L1;ERRFI1;USP8
beta-2 adrenergic receptor bindingPDE4D;NEDD4;SLC9A3R1;GNAS;BDKRB2
cAMP bindingRAPGEF4;CNMPD1;PDE4D;HCN2;CNGA2;PDE11A;PDE10A;PRKAR1B;POPDC2
drug bindingPPP3CB;MT3;FOLR2;PNP;FOLR1;GLRB;CHRNA3;GABRA1;SRP54A
enzyme bindingCABYR;MSH2;TNKS2;Txn1;GSTM4;PRKCA;SCNM1-PS;PEX5;TSPYL1
ion channel bindingFYN;ACTN2;CIB1;PACS1A;AASS;ACTN1;CAV3;FHL1;PDE4B
metal ion bindingMINA;PLEKHM1;CLCA1;FDX1B;LHX6;ZNF136;ZNF831;ZSCAN4F;PICK1
protein bindingANXA9;CLCNKB;KAL1;PAK1IP1;STAT6;RAB9B;SYCP1;PPP1R8;CLN5
scaffold protein bindingDSP;KRT15;TREM1;KCNA5;NLGN4Y;P2RY1;CIT;SHANK1;CACNA1G
ubiquitin protein ligase bindingRNF40;IKBKE;NPLOC4;Fzd4;SLC22A18;AURKA;PDE4D;TRAF4;EGFR

PDE4D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4D here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4D.

COIL; MAGEA6; GOLGA8F; GOLGA8DP; TRAF1; Bub1; AKAP12; SHANK2; q8d0r7_yerpe; ARRB2

Research Area

Related articles

Nagasaki, K; Iida, T; et al. PRKAR1A Mutation Affecting cAMP-Mediated G Protein-Coupled Receptor Signaling in a Patient with Acrodysostosis and Hormone Resistance. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 97:E1808-E1813(2012).
Dostaler-Touchette, V; Bedard, F; et al. Cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase is functional in bovine mammary gland. JOURNAL OF DAIRY SCIENCE 92:3757-3765(2009).
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