• Official Full Name

    phosphodiesterase 4D, cAMP-specific

  • Background

    This gene encodes one of four mammalian counterparts to the fruit fly dunce gene. The encoded protein has 3,5-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
  • Synonyms

    PDE4D; phosphodiesterase 4D, cAMP-specific; DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2; cAMP-specific 3,5-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila);
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • His|GST
    • Myc
    • DDK
    • N/A
    • No tag
    Species Cat.# Product name Source (Host) Tag Price
    Human PDE4D-10H Active Recombinant Human PDE4D protein, GST-tagged Insect Cell GST
    Human PDE4D-1601H Recombinant Human PDE4D, GST-tagged E.coli GST
    Human PDE4D-28756TH Recombinant Human PDE4D N/A
    Human PDE4D-478H Recombinant Human PDE4D, GST-tagged, Active Sf9 Insect Cell GST
    Human PDE4D-3350HCL Recombinant Human PDE4D 293 Cell Lysate HEK293 N/A
    Human PDE4D-1602H Recombinant Human PDE4D protein, His-tagged E.coli His
    Human PDE4D-0556H Recombinant Human PDE4D Protein (T388-S715), Tag Free E.coli No tag
    Human PDE4D-303H Recombinant Human PDE4D Protein, His/GST-tagged E.coli His/GST
    Human PDE4D-0557H Recombinant Human PDE4D Protein (T388-S715), His tagged E.coli His
    Human PDE4D19751H Recombinant Human PDE4D (388-715) Protein
    Human PDE4D-1687H Recombinant Human PDE4D Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Pde4d-4747M Recombinant Mouse Pde4d Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat PDE4D-4332R Recombinant Rat PDE4D Protein Mammalian Cell His
    Rat PDE4D-3992R Recombinant Rat PDE4D Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat PDE4D-3992R-B Recombinant Rat PDE4D Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • PDE4D Related Articles

    PDE4D involved in several pathways and played different roles in them. We selected most pathways PDE4D participated on our site, such as Purine metabolism, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolismAMPD2;AK3;NT5C1BA;PKM2;NME1-NME2;PDE6H;POLR2G;NT5C1B;ENTPD8
    cAMP signaling pathwayRRAS2;PDE4D;PRKACB;HTR1A;NPR1;NPY;HTR1E;GPR81;CAMK4

    PDE4D has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, ATPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4D itself. We selected most functions PDE4D had, and list some proteins which have the same functions with PDE4D. You can find most of the proteins on our site.

    Function Related Protein
    3,5-cyclic-AMP phosphodiesterase activityPDE4D;PDE1B;PDE7A;PDE4B;PDE8A;PDE3A;PDE4C;PDE8B;PDE4A
    3,5-cyclic-nucleotide phosphodiesterase activityPDE5A;PDE10A;PDE9A;PDE3B;PDE11A;PDE4D;PDE5AB;PDE8B;PDE8A
    beta-2 adrenergic receptor bindingPDE4D;BDKRB2;NEDD4;GNAS;SLC9A3R1
    ion channel bindingUSP10;ARRB1;KCNC1;CTNNB1;SNTA1;PRNP;HTT;YWHAQ;BAK1
    metal ion bindingRIMKLA;ZNFL2A;APTX;ARG2;CYB561;ZFP503;KDM2BA;LHX1A;ZNF502
    protein bindingCYTH2;NUP50;ELF3;ZNF302;STOML2;DNALI1;CDK15;RPS10;RSG1
    scaffold protein bindingCIT;CHRNA7;KRT5;ATP2B4;KCNH2;P2RY1;PDE4D;NOS3;CRIPT
    ubiquitin protein ligase bindingTRP53;RNF34;CASP10;SNX9;ZFP746;RAD18;EGFR;UBXN1;UBE2C

    PDE4D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4D here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4D.

    COIL; MAGEA6; GOLGA8F; GOLGA8DP; TRAF1; Bub1; AKAP12; SHANK2; q8d0r7_yerpe; ARRB2

    Nagasaki, K; Iida, T; et al. PRKAR1A Mutation Affecting cAMP-Mediated G Protein-Coupled Receptor Signaling in a Patient with Acrodysostosis and Hormone Resistance. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 97:E1808-E1813(2012).
    Dostaler-Touchette, V; Bedard, F; et al. Cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase is functional in bovine mammary gland. JOURNAL OF DAIRY SCIENCE 92:3757-3765(2009).
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