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PLAT

  • Official Full Name

    plasminogen activator, tissue

  • Overview

    Tissue plasminogen activator (abbreviated TPA or PLAT) is a protein involved in the breakdown of blood clots. It is a serine protease (EC 3.4.21.68) found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for clot breakdown. Because it works on the clotting system, tPA is used in clinical medicine to treat only embolic or thrombotic stroke. Use is contraindicated in hemorrhagic stroke and head trauma.
  • Synonyms

    PLAT; plasminogen activator, tissue; TPA; T-PA; DKFZp686I03148; tissue-type plasminogen activator; alteplase; reteplase; OTTHUMP00000225783; OTTHUMP00000225784; OTTHUMP00000225785; OTTHUMP00000225786; OTTHUMP00000225787; OTTHUMP00000225788; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Therapeutic Proteins
  • Native Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Fc
  • Fc|His
  • GST|His
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • SUMO
  • DDK
  • Myc|DDK
  • N/A
  • N
  • hFc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLAT-1109H Active Recombinant Human PLAT protein, His-tagged CHO His Met1-Pro562
Human PLAT -79H Non-cleavable Recombinant Human Tpa Insect Cell N/A
Human PLAT-1292H Recombinant Human Plasminogen Activator, Tissue Insect Cell N/A
Human PLAT-1291H Recombinant Human Plasminogen Activator, Tissue Insect Cell N/A
Human PLAT-72H Active Recombinant Human PLAT protein(Ile311-Pro562), hFc-tagged HEK293 N-hFc Ile311-Pro562
Human PLAT-5461H Recombinant Human Plasminogen Activator, Tissue CHO N/A
Human PLAT-2737H Recombinant Human PLAT protein, His-tagged E.coli His Ser36~Thr126
Human PLAT-051H Recombinant Human PLAT Protein, His-tagged HEK293 His
Human PLAT-3123H Recombinant Human PLAT, Fc-His tagged Human Cell Fc/His
Human PLAT-55H Recombinant Human Plasminogen Activator, Tissue CHO N/A
Human PLAT-052H Recombinant Human PLAT Protein, GST and His-tagged E.coli GST/His
Human PLAT-1290H Recombinant Human Plasminogen Activator, Tissue Insect Cell N/A
Human PLAT-8525H Recombinant Human PLAT protein(Tyr37-Arg310), hFc-tagged HEK293 N-hFc Tyr37-Arg310
Human PLAT -77H Recombinant Human tissue plasminogen activator, single chain, FITC labeled CHO N/A
Human PLAT -80H Non-enzymatic non-cleavable Recombinant Human tPA Insect Cell N/A
Human PLAT -78H Recombinant Human tissue plasminogen activator, single chain, Texas Red CHO N/A
Human PLAT-882H Recombinant Human PLAT, None tagged Human Cell N/A
Human PLAT-2738H Recombinant Human PLAT protein, His & GST-tagged E.coli His/GST Ile311~Pro562 (Accession # P00750)
Human PLAT-2833HCL Recombinant Human PLAT cell lysate Human Cell N/A
Human PLAT-4925H Recombinant Human PLAT Protein (Ser36-Pro562), N-His tagged Mammalian cells N-His Ser36-Pro562
Human PLAT-1870H Recombinant Human PLAT Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PLAT-1553H Recombinant Human PLAT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PLAT-P005H Recombinant Human PLAT therapeutic protein CHO N/A 527 Aa
Human PLAT-4474H Recombinant Human PLAT protein, His&Myc-tagged Insect Cell His&Myc 36-562aa(R497Q)
Human PLAT-29690TH Native Human Human SERPINE1 N/A
Human PLAT-30946TH Native Human PLAT N/A
Human PLAT-4473H Recombinant Human PLAT protein, His&Myc-tagged Insect Cell His&Myc 36-562aa(Y471H)
Human PLAT-3346H Recombinant Human PLAT protein, His-SUMO-tagged E.coli His-SUMO 36-556aa
Human PLAT-36H Reteplase Reference standard N/A
Human PLAT-13H Fully Active Recombinant Human PLAT Protein CHO
Human PLAT-3347H Recombinant Human PLAT protein, His-SUMO-tagged E.coli His-SUMO 314-556aa
Human PLAT-169H Recombinant Human Tissue Plasminogen Activator Reference standard N/A
Human PLAT-P033H Recombinant Human PLAT therapeutic protein CHO N/A 355 Aa
Human PLAT-142H Tissue Plasminogen Activator (tPA) Antigen in Plasma Reference standard N/A
Human PLAT-4926H Recombinant Human PLAT Protein (Ser36-Thr126), His tagged E.coli His Ser36-Thr126
Human PLAT-30920TH Native Human PLAT N/A
Mouse Plat-5463M Recombinant Mouse Plasminogen Activator, Tissue Insect Cell N/A
Mouse PLAT-926M Recombinant Mouse PLAT Protein, Fc-tagged HEK293 Fc
Mouse Plat-2739M Recombinant Mouse Plat protein, His-tagged E.coli His Glu359~Leu532 (Accession # P11214)
Mouse PLAT-1498MCL Recombinant Mouse PLAT cell lysate Human Cell N/A
Mouse Plat-4907M Recombinant Mouse Plat Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PLAT-4494R Recombinant Rat PLAT Protein Mammalian Cell His
Rat Plat -95R Recombinant Active rat tPA Insect Cell N/A
Rat Plat-2741R Recombinant Rat Plat protein, His-tagged E.coli His Gly311~Asn487
Rat Plat -96R Recombinant Active rat tPA, two chain Insect Cell N/A
Rat Plat-5462R Recombinant Rat Plasminogen Activator, Tissue Insect Cell N/A
Rat PLAT-4154R-B Recombinant Rat PLAT Protein Pre-coupled Magnetic Beads HEK293
Rat PLAT-4154R Recombinant Rat PLAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit PLAT -90R Recombinant Active Rabbit tPA Insect Cell N/A
Pig PLAT-2740P Recombinant Pig PLAT protein, His & GST-tagged E.coli His/GST Val39~Pro562 (Accession # Q8SQ23)
Pig PLAT-1293P Recombinant Pig Plasminogen Activator, Tissue Insect Cell N/A
Pig PLAT -84P Recombinant Active porcine tPA Insect Cell N/A
Kit-0701 PLAT (Human) Chromogenic Activity Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PLAT Related Articles
  • PLAT Related Research Area

PLAT involved in several pathways and played different roles in them. We selected most pathways PLAT participated on our site, such as Complement and coagulation cascades, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesCFB;KNG1;CD59;SERPINF2;BDKRB2;SERPINA1D;F13A1;C3AR1;SERPING1
Transcriptional misregulation in cancerMYCN;TAF15;HIST1H3E;NGFR;MPO;ETV5;FUT8;CDK14;HDAC1

PLAT has several biochemical functions, for example, glycoprotein binding, phosphoprotein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLAT itself. We selected most functions PLAT had, and list some proteins which have the same functions with PLAT. You can find most of the proteins on our site.

Function Related Protein
glycoprotein bindingBMPR1A;BMPR1B;FBXO2;Shh;EDEM2;CSNK1D;EDEM1;PTBP3;RASA1
phosphoprotein bindingCACNB2;LYN;CSNK1D;TBK1;GPRIN1;YWHAE;FKBP4;TOX3;URI1
protein bindingBUC;BBS13;PHB;KEAP1;EIF1AD;PSMA6;KHDRBS3;PDIK1L;C14orf93
receptor bindingNTF3;KCNA5;FGF11A;WNT4B;FGF13B;LEPROT;ASIP;LRRC4B;CADM2
serine-type endopeptidase activityEGFBP2;HTRA1A;LOC780933;HABP2;PRTN3;TMPRSS2;PRSS58;KLK13;PREPL

PLAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLAT here. Most of them are supplied by our site. Hope this information will be useful for your research of PLAT.

SERPINE1; Plgrkt

Jiang, WL; Zheng, Z; et al. Demodulation for hydraulic pump fault signals based on local mean decomposition and improved adaptive multiscale morphology analysis. MECHANICAL SYSTEMS AND SIGNAL PROCESSING 58-59:179-205(2015).
Didenko, AN; Vodovozov, VY; et al. Paleomagnetism of the Ulkan massif (SE Siberian platform) and the apparent polar wander path for Siberia in late Paleoproterozoic-early Mesoproterozoic times. PRECAMBRIAN RESEARCH 259:58-77(2015).
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