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PRF1

  • Official Full Name

    perforin 1 (pore forming protein)

  • Overview

    The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
  • Synonyms

    PRF1; perforin 1 (pore forming protein); P1; PFP; FLH2; PFN1; HPLH2; perforin-1; cytolysin; lymphocyte pore forming protein; lymphocyte pore-forming protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • Human Cytotoxic Granules of YT Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • SUMO
  • MBP
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRF1-29996TH Recombinant Human PRF1 Wheat Germ N/A 95 amino acids
Human PRF1-25H Recombinant Human PRF1 protein, His/GST-tagged E.coli His/GST
Human PRF1-326H Recombinant Human PRF1 Mammalian Cell His
Human PRF1-30288TH Recombinant Human PRF1 Wheat Germ N/A 534 amino acids
Human PRF1-1942H Recombinant Human PRF1, His-tagged E.coli His 247-555aa
Human PRF1-158H Recombinant Human PRF1 protein, His-tagged E.coli His Pro22~Trp555
Human PRF1-2873HCL Recombinant Human PRF1 293 Cell Lysate HEK293 N/A
Human PRF1-2252H Recombinant Human PRF1 protein, MBP&His-tagged Insect Cell MBP&His 22-555aa
Human PRF1-3904H-B Recombinant Human PRF1 Protein Pre-coupled Magnetic Beads HEK293
Human PRF1-26H Recombinant Human PRF1 protein, His-SUMO-tagged E. coli His-SUMO 22-555aa
Human PRF1-3904H Recombinant Human PRF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PRF1-55H Native Human Perforin Human Cytotoxic Granules of YT Cell N/A
Human PRF1-5976H Recombinant Human PRF1 Protein (Gln411-Gly531), N-His tagged E.coli N-His Gln411-Gly531
Human PRF1-392HF Recombinant Full Length Human PRF1 Protein In Vitro Cell Free System 534 amino acids
Human PRF1-01H Recombinant Human PRF1 Protein, His-Tagged E.coli His
Mouse Prf1-25M Recombinant Mouse Prf1 protein, His/GST-tagged E.coli His/GST
Mouse PRF1-1931M Recombinant Mouse PRF1 Protein (21-554 aa), His-tagged Yeast His 21-554 aa
Mouse PRF1-3230M Recombinant Mouse PRF1 protein, His-tagged E.coli His Val40~Lys355
Mouse PRF1-192M Recombinant Mouse PRF1 protein, His-tagged E.coli His 21-554aa
Rat Prf1-6804R Recombinant Rat Prf1 protein, His & T7-tagged E.coli His/T7 Ala120~Asp353 (Accession # P35763)
Rat PRF1-738R Recombinant Rat PRF1 Protein (25-554 aa), His-tagged E.coli His 25-554 aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRF1 Related Articles
  • PRF1 Related Research Area

PRF1 involved in several pathways and played different roles in them. We selected most pathways PRF1 participated on our site, such as Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Autoi, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Natural killer cell mediated cytotoxicityIFNA21;PAK1;PPP3CC;IFNA17;RAET1D;KLRC2;FCGR3;SHC1;H60a
Type I diabetes mellitusPTPRN;IL1A;GAD1;HLA-B;CD80;HLA-DMA;HLA-DQA1;H2-AA;INS2
AutoiPRF1;TG;IFNA2;IFNA1;HLA-DRB3;TSHB;HLA-DQB1;HLA-DRB4;HLA-A
ne thyroid diseaseIFNA8;IL5;HLA-DRB1;IFNA16;TSHB;CD40;TPO;HLA-DQB1;Il2
Allograft rejectionIL4;HLA-DOB;HLA-DMA;CD28;H2-AB1;CD86;H2-AA;HLA-DRB5;IFNG
Graft-versus-host diseaseH2-Q10;HLA-DPB1;HLA-DRB5;HLA-DMB;KIR3DL2;KIR2DL1;GZMB;TNF;IL1B
Viral myocarditisHLA-C;CCND1;ITGAL;CD80;ICAM1;HLA-DMB;CD40;ITGB2;HLA-DRB3

PRF1 has several biochemical functions, for example, calcium ion binding, protein binding, wide pore channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRF1 itself. We selected most functions PRF1 had, and list some proteins which have the same functions with PRF1. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingS100Z;CABP5;CAPN3A;SPARC;PCDHA9;SULF2A;NKD2;CALR3B;JAG1A
protein bindingKLF3;CALU;USP37;CMKLR1;CDC42SE2;DYNLT3;TRIM28;CSNK2A1;TLK2
wide pore channel activityPANX1A;PANX1B;PANX2;PRF1

PRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRF1.

KRT31; SRGN; GZMB; ompC; DDX24

Balada, E; Castro-Marrero, J; et al. Clinical and serological findings associated with the expression of ITGAL, PRF1, and CD70 in systemic lupus erythematosus. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 32:113-116(2014).
Ceccarelli, F; D'Alfonso, S; et al. The role of eight polymorphisms in three candidate genes in determining the susceptibility, phenotype, and response to anti-TNF therapy in patients with rheumatoid arthritis. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 30:939-942(2012).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What signaling pathways or stimuli influence the expression of perforin (PRF1) in immune cells? 07/09/2022

Signaling pathways and stimuli such as T cell receptor (TCR) activation and exposure to infected cells influence the expression of perforin (PRF1) in immune cells.

In which immune cells is PRF1 expression particularly upregulated or modulated? 04/23/2022

PRF1 expression is particularly upregulated or modulated in cytotoxic immune cells such as cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells.

Are there specific diseases or conditions associated with dysregulation or abnormal expression of PRF1? 08/19/2021

Dysregulation or abnormal expression of PRF1 is associated with conditions like hemophagocytic lymphohistiocytosis (HLH) and certain autoimmune disorders.

How does perforin (PRF1) expression change under conditions of immune activation or response? 05/05/2021

Perforin (PRF1) expression changes during immune activation, often being upregulated in response to various stimuli.

What factors influence the balance between upregulation and downregulation of PRF1 in immune cells? 09/04/2018

The balance between upregulation and downregulation of PRF1 is influenced by various factors, including the type of immune response and the microenvironment.

What is the significance of altered PRF1 expression in the context of immune surveillance and cytotoxicity? 10/14/2017

Altered PRF1 expression is significant for immune surveillance, as it plays a crucial role in the cytotoxicity of immune cells against infected or aberrant cells.

How does PRF1 contribute to immune responses against infected or aberrant cells, and what is its role in cytotoxicity? 04/29/2017

PRF1 contributes to immune responses by enabling immune cells to induce apoptosis in target cells, contributing to cytotoxicity.

Customer Reviews (3)

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Reviews
07/04/2022

    We observed remarkable consistency in product performance across multiple batches, reducing variability in our experiments.

    11/14/2018

      The manufacturer's history of producing high-quality products contributed to our trust in this protein.

      05/11/2018

        Collaboration with other research groups was made easier by the product's standardized use in the scientific community.

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