Recombinant Human Perforin 1 Protein

• Cat.No.: PRF1-02H
• Product Overview: Recombinant human perforin 1 (PRF1) (aa 32-316) without tag was expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 32-316 aa
• Description: This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood.
• Form: Lyophilized
• Molecular Mass: 62 kDa
• Purity: ≥ 95%
• Stability: Stable at 2-8 centigrade for one month. Stable at -80 centigrade for up to 12 months.
• Storage: Short Term Storage: +4 centigrade Long Term Storage: -80 centigrade Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80 centigrade.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH 8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
• Shipping: Blue Ice

Gene Information

• Gene Name: PRF1 perforin 1 [ Homo sapiens (human) ]
• Official Symbol: PRF1
• Synonyms: PRF1; perforin 1; P1; PFP; HPLH2; perforin-1; cytolysin; lymphocyte pore-forming protein; perforin 1 (pore forming protein)
• Gene ID: 5551
• mRNA Refseq: NM_005041
• Protein Refseq: NP_005032
• MIM: 170280
• UniProt ID: P14222